A5052381057- Autophagy in Disease and Therapy
- COVID-19 Pandemic Impacts
- COVID-19 epidemiological studies
- Advanced Drug Delivery Systems
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Advanced Nanomaterials in Catalysis
- Microtubule and mitosis dynamics
- Trypanosoma species research and implications
- Bioactive Compounds and Antitumor Agents
- Inflammasome and immune disorders
- Marine Sponges and Natural Products
- Electrospun Nanofibers in Biomedical Applications
- Epigenetics and DNA Methylation
- Coenzyme Q10 studies and effects
- Wound Healing and Treatments
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- Sirtuins and Resveratrol in Medicine
- Cancer Research and Treatments
- Nutrition, Genetics, and Disease
- Biopolymer Synthesis and Applications
Thapar Institute of Engineering & Technology
2021-2024
Sri Guru Granth Sahib World University
2020-2021
University of Calcutta
2014-2020
Siemens (United States)
2016
The biological significance of microtubules makes them a validated target cancer therapy. In this study, we have utilized indole, an important pharmacological scaffold, to synthesize novel bis(indolyl)-hydrazide–hydrazone derivatives (NMK-BH compounds) and recognized NMK-BH3 as the most effective one in inhibiting A549 cell proliferation assembly tissue-purified tubulin. Cell viability experiments showed that inhibited human lung adenocarcinoma (A549) cells, normal fibroblasts (WI38)...
The short half-life in the GI tract necessitates an excess of drugs causing side effects oral formulations. Here, we report development and deployment Bacterioboat, which consists surface-encapsulated mesoporous nanoparticles on metabolically active Lactobacillus reuteri as a drug carrier suitable for administration. Bacterioboat showed up to 16% loading its dry weight, intestinal anchorage around alveoli regions, sustained release, stability physiological conditions 24 hours. In vivo...
Colchicine is a well-known and potent microtubule targeting agent, but the therapeutic value of colchicine against cancer limited by its toxicity normal cells. But, there no report cytotoxic potential lung cell, at clinically permissible or lower concentrations, minimally toxic to non-cancerous Hence, in present study, we investigated possible mechanism which efficacy cells less dose could be enhanced. admissible concentration 2.5 nM had effect caused G2/M arrest A549 However, this...
Paclitaxel (Tx) is one of the first-line chemotherapeutic drugs used against lung cancer, but acquired resistance to this drug a major challenge successful chemotherapy. In work, we have focused on chronological changes various cellular parameters and associated effect Tx (10 nM) development in A549 cell line. It was observed, at initial stage, death percentage due treatment had increased up 20 days, thereafter, it started declining became completely resistant by 40 days. Expressions βIII...
Aim: Paclitaxel (PTX) has no clinically available oral formulations. Cetyl alcohol is metabolized by dehydrogenase and aldehyde that are overexpressed in cancer cells. So, PTX-encapsulated core–shell nanoparticle of cetyl (PaxSLN) could target the cells through route. Materials & methods: PaxSLN was synthesized using microemulsion template. Efficiency evaluated ALDEFLUOR™, multicellular tumor spheroid formation inhibition assays CT26 colorectal carcinoma animal model. Pharmacokinetics...
<title>Abstract</title> The G-Quadruplex (G4) silencer element (Pu-27), an epigenetic regulator located upstream of the c-Myc promoter, when stabilized and restored to its basal expression, presents a potential avenue for effective anticancer therapy. This study investigates Hesperidin, citrus flavanone, as breast cancer therapy by targeting G-quadruplex element, Pu-27. Hesperidin showed strong interaction with Pu-27, indicated binding score -7.241 formation hydrogen bonds five regions Pu-27...
Abstract The second wave of COVID-19 exerted more catastrophe in India than the first. progressions both waves were heterogeneous six different regions involving 28 states and 8 union territories. An analysis temporal variations new cases fatalities all was done for 1st (30th January 2020 to 31st 2021) 2nd (1st February 2021 29th May 2021), which showed that accounted over 16% 9% world respectively. Southern Western remained top contributor waves. state Punjab Maharashtra reported highest...
The organic extract of a marine sponge Petrosia alfiani selectively inhibited iron chelator-induced hypoxia-inducible factor-1 (HIF-1) activation in human breast tumor T47D cell-based reporter assay. Bioassay-guided fractionation yielded seven xestoquinones (1 - 7) including three new compounds 14-hydroxymethylxestoquinone (1), 15-hydroxymethylxestoquinone (2), and 14,15-dihydroxestoquinone (3). Compounds 1 7 were evaluated for their effects on HIF-1 signaling, mitochondrial respiration,...
Abstract COVID-19 second wave, in India, exerted more catastrophe than the first. The progressions of both waves were heterogeneous six different regions involving 28 states and 8 union territories. An analysis temporal variations new cases fatalities all India was done for 1st (30th January 2020 to 31st 2021) 2nd wave (1st February 2021 29th May showed accounted over 16% 9% world respectively. Southern Western remained top contributor waves. state Punjab Maharashtra reported highest CFR...