A5036705189- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Photochemistry and Electron Transfer Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organic Light-Emitting Diodes Research
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Essential Oils and Antimicrobial Activity
- Organic Electronics and Photovoltaics
- Polydiacetylene-based materials and applications
- Supramolecular Chemistry and Complexes
- Phytochemicals and Antioxidant Activities
- Crystallography and molecular interactions
- Conducting polymers and applications
- Asymmetric Synthesis and Catalysis
- Luminescence Properties of Advanced Materials
- Fullerene Chemistry and Applications
- Computational Drug Discovery Methods
- Photochromic and Fluorescence Chemistry
- Free Radicals and Antioxidants
- Innovative Microfluidic and Catalytic Techniques Innovation
- Supramolecular Self-Assembly in Materials
Homi Bhabha National Institute
2019-2024
Bhabha Atomic Research Centre
2014-2024
Institut de Chimie et Procédés pour l'Energie, l'Environnement et la Santé
2015-2019
Centre National de la Recherche Scientifique
2015-2019
University of Mumbai
2016-2019
Institut Européen de Chimie et Biologie
2018-2019
University College London
2018
Medical Research Council
2018
Institut de Chimie
2018
Université de Strasbourg
2010
In an attempt to develop a photostable and efficient pyrromethene compound for use in liquid dye lasers, three congeners of the commercially available 567 (PM567) laser were synthesized their photophysical properties, lasing efficiencies, photochemical stabilities studied. general presence aryl group at C-8 chromophore increased photostability. One possessing trimethoxyphenyl moiety showed significantly improved parameters than PM567. Compared PM567, stability new was 2-fold, while it...
The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the ethanol extracts three varieties (Bangla, sweet, and Mysore) Piper betel (pan) revealed Bangla variety to possess best antioxidant activity that can be correlated with total phenolic content reducing powers respective extracts. Column chromatography extract led isolation chevibetol (CHV), allylpyrocatechol (APC), their glucosides. HPTLC analyses similar chemical profiles in all P. varieties, although concentrations CHV APC were...
The conventional concept of selective complexation actinides with soft donor ligands (either S or N donor) has been modified here through exploiting the concept, "intra-ligand synergism", where a hard atom, such as oxygen preferentially binds to trivalent [An(iii)] compared valence iso-electronic lanthanides [Ln(iii)] in presence another centre. We have theoretically predicted selectivity 1,10-phenanthroline-2,9-dicarboxylamide towards Am(iii) ion density functional calculations....
Abstract The recent emergence of pandemic coronavirus (COVID‐19) caused by SARS‐CoV‐2 has raised significant global health concerns. More importantly, there is no specific therapeutics currently available to combat against this deadly infection. enzyme 3‐chymotrypsin‐like cysteine protease (3CLpro) known be essential for viral life cycle as it controls the replication. 3CLpro could a potential drug target established before in case severe acute respiratory syndrome (SARS‐CoV) and Middle East...
Currently, effective therapeutic modalities for pancreatic ductal adenocarcinoma (PDAC) are quite limited, leading to gloomy prognosis and ∼6-months median patient survival. Recent advances showed the promise of photodynamic therapy (PDT) PDAC patients. Next generation photosensitizers (PS) based on "organelle-targeted-PDT" provide new paradigm in field precision medicines address current challenge treating PDAC. In this investigation, we have constructed a novel PS, named as
Despite of having many advantages over the popular cancer therapies, photodynamic therapy still is not widely acceptable for clinical applications. Scarcity efficient triplet photosensitizers (PSs) one main bottlenecks this. Although numerous heavy atom attached PSs are developed as PDT agents, but these suitable applications due to several reasons. Thus, development heavy-atom-free organic urgently required. In this context, new type helical BODIPYs discussed. have rich photophysical...
Abstract Bodipy laser dyes are highly efficient but degrade rapidly in solution by reacting with situ generated singlet oxygen ( 1 O 2 ). To increase the lasing lifetimes of these dyes, we have designed and synthesised two different congeners widely studied Pyrromethene 567 (PM567) substitution at boron centre and/or both meso position. The new showed high efficiencies increased photostability. results theoretical pulse radiolysis studies revealed that reduced generation capacity as well...
Abstract Three boradiazaindacene (BODIPY) dyes with different‐coloured (greenish‐yellow, orange and red) fluorescence good Stokes shifts were synthesised starting from the greenish‐yellow BODIPY dye PM546. The high of are due to release steric strain in their excited states relative that highly twisted ground states. One these compounds might be a useful water‐soluble fluorophore, whereas other two promising H + sensors.
Designing heavy-atom-free triplet photosensitizers (PSs) is a challenge for the efficient photodynamic therapy (PDT) of cancer. Helicenes are twisted polycyclic aromatic hydrocarbons (PAHs) with an intersystem crossing (ISC) that proportional to their twisting angle. But difficult syntheses and weak absorption profile in visible spectral region restrict use as PSs PDT. On other hand, boron-containing PAHs, BODIPYs highly recognized outstanding optical properties. However, planar BODIPY dyes...
Abstract The leaves of Piper betle (locally known as Paan) have long been in use the Indian indigenous system medicine for relief pain; however, underlying molecular mechanisms this effect not elucidated. anti-inflammatory and immunomodulatory effects an ethanolic extract P. (100 mg kg−1; PB) were demonstrated a complete Freund's adjuvant-induced model arthritis rats with dexamethasone (0.1 kg−1) positive control. At non-toxic concentrations PB (5–25 μg mL−1), dose-dependent decrease...
Starting from some meso-methyl Bodipy dyes, the corresponding meso-styryl derivatives were synthesized by regioselective Knoevenagel-type condensation with different aromatic aldehydes. The reactions driven alleviation of structural strain alkyl substituted Bodipys that could override differential acidities methyl protons at pyrrole ring moiety.
Abstract In the present study, we demonstrated effect of hydrogen bonding in semiconducting behaviour a small molecule used organic field‐effect transistors (OFETs). For this highly soluble dumbbell‐shaped molecule, Boc‐TATDPP based on Boc‐protected thiophene‐diketopyrrolopyrrole (DPP) and triazatruxene (TAT) moieties was used. The two Boc groups were removed by annealing at 200 °C, which created strong hydrogen‐bonded network NH‐TATDPP supported additional π–π stacking. These characterised...
Present study reports the interaction of a molecular rotor based BODIPY dye, 8-anilino-BODIPY (ABP), with versatile macrocyclic molecule, cucurbit[7]uril (CB7), investigated through various techniques such as ground-state absorption, steady-state fluorescence, time-resolve emission, proton NMR, and quantum chemical studies. Although dyes have widespread applications due to their intriguing photochemical properties, studies on noncovalent interactions different hosts, especially regarding...
Highly sensitive and selective near-infrared turn-on fluorescent bioprobe for serum albumin detection quantification is developed based on unadulterated BODIPY- O -glycoside nanoparticles.
A ratiometric fluorescence “off-on” dosimeter is developed using bare BODIPY dye, 8-( N , -dimethylanilino) BODIPY. The useful for the detection of gamma radiation in range 0.5–150 Gy with a 0.5 limit detection.
We have designed and synthesized a series of modular, dual-color dyes comprising conventional boron dipyrromethene (Bodipy) dye, as yellow emitter, Bodipy dye possessing extended conjugation that functions red emitter. A flexible tether variable length, built from ethylene glycol residues, connects the terminal dyes. critical design element this type dyad relates to secondary amine linkage interposed between tether. Cyclic voltammetry shows both be electroactive indicates is quite easily...
New synthetic strategies were developed for the synthesis of indolo-pyridine boron difluoride (IPBD) dyes and antiladder-type π-conjugated based on pyridine/pyrazine-indolocarbazole (ICZ) structures. The photophysical electrochemical properties measured in solution, solid state, thin films rationalized by theoretical calculations. Interestingly, these can be tuned a wide range using chemical route. For example, absorption fluorescence color solution state HOMO-LUMO energy gaps structure...
An efficient and chemoselective route for transforming BF2–BODIPYs to Et2B-BODIPYs (masking) was developed using Et2AlCl. The Et groups can be easily replaced with F atoms BF3·Et2O in moist CH2Cl2 regenerate the (demasking). masking–demasking strategy is very useful synthesizing functionalized BODIPYs via nucleophilic reductive reactions. masking used synthesize a BODIPY dimer by McMurry coupling of formyl Et2B–BODIPY, while new an asymmetrically substituted B-center synthesized demasking strategy.
We have designed a series of modular and fluorescent poly(arylester) dendrimers functionalized with cyanobiphenyl subunits borondipyrromethene (Bodipy) dyes. The green emitter is Bodipy four methyl groups, the dye possessing extended conjugation two vinyl groups acts as red emitter. design element these architectures relates to secondary amide linkers interposed between conventional dendrons. second- third-generation give rise nematic and/or smectic A phases, whereas first-generation show C...
Severely immunocompromised human immunodeficiency virus (HIV)–infected individuals have high mortality shortly after starting antiretroviral therapy (ART). We investigated predictors of early and "late presenter" phenotypes. The Reduction EArly MortaLITY (REALITY) trial enrolled ART-naive adults children ≥5 years age with CD4 counts <100 cells/µL initiating ART in Uganda, Zimbabwe, Malawi, Kenya. Baseline through 48 weeks were identified using Cox regression backwards elimination (exit P >...