Turnover rate is an important aspect of the regulation plant processes by growth substances. To study turnover indole-3-acetic acid (IAA), two [alpha]-methyltryptophan-resistant lines (MTR1 and MTR2) Lemna gibba were generated nitrosomethyl urea treatment inbred line derived from L. G-3. In this report we describe: (a) development a selection system using near isogenic gibba; (b) techniques for chemical mutation [alpha]-methyltryptophan resistance; (c) partial characterization selected...

An empirical model is presented for hepatic elimination of substrates which treats the liver as a series compartments. The number compartments serves an adjustable parameter and determines effect changes in blood flow on elimination. By allowing variable dependence clearance flow, bridge between extreme cases venous equilibrium (the "well-stirred" model) "parallel-tube" model. can be determined by measuring at different rates or extents binding substrate to components. Examples are given...

The pharmacokinetics of cefetamet pivoxil during administration ascending oral doses were studied in 16 male normal healthy volunteers (age, 24.5 +/- 2.1 years; weight, 73.5 8.5 kg). subjects randomly assigned to four treatments 500, 1,000, 1,500, and 2,000 mg according a four-by-four Latin square design. After an overnight fast, the drug was administered 10 min after standard breakfast. It found that both rate extent prodrug absorption, measured as adsorption, reduced with increasing doses....

Cefetamet pivoxil (1,000 mg orally) absorption was evaluated in 16 male subjects (age, 23.4 +/- 1.7 years; weight, 73.9 7.0 kg) 1 h before (BE), with (WI), and after (AF) a standard breakfast. The time to peak concentration of cefetamet plasma (Tmax) increased from 3.25 1.44 the BE group 4.31 1.54 4.13 WI AF groups, respectively (P less than 0.05). maximum (Cmax) area under concentration-time profiles (AUC) BE, WI, groups were 5.50 1.06, 5.47 1.4, 6.57 0.93 micrograms/ml 38.2 10.1, 35.7...

Summary To help clarify whether food or enteral nutrients decrease hydralazine relative bioavailability, eight subjects were given oral under four nutritional conditions: fasted (F), with a standard breakfast (SB), bolus of (EB), and slow infusion administered by nasogastric tube (EI). The area the curve maximum concentration values much higher conditions than conditions, indicating that absorption and/or disposition kinetics may be altered food. median (range) for these parameters 2,641...

SUMMARY 123I-labelled iodoazomycin arabinoside (123I-IAZA) is an experimental radiopharmaceutical that has been shown to have clinical utility for imaging regional tissue hypoxia. We report the pharmacokinetics of IAZA, radiopharmacokinetics 123I-IAZA and total radioactivity kinetics after injection 123I-IAZA. Six healthy volunteers each received intravenous bolus 185 MBq Thirteen blood samples a cumulative urine sample were collected over 28 h from subject. A two-compartment open model best...

A physiological model of propranolol disposition was designed to help explain the large increase in AUC seen when drug is administered with food. The mass balance equation for liver compartment used Michaelis-Menten terms describe hepatic metabolism. Previously published pharmacokinetic and parameters were throughout. three parameters, Qh, Kmt, Vmax, varied different durations by a factor two AUC. parameter variations patterned after changes splanchnic blood flow following high protein meal....

To determine if iron binds strongly to captopril and reduces absorption.A variety of in vitro experiments was conducted examine binding a randomized, double-blind, placebo controlled, cross-over study design used assess the vivo interaction. Captopril (25 mg) coingested with either ferrous sulphate (300 or by seven healthy adult volunteers. Subjects were phlebotomized had blood pressure measured at 0, 0.25, 0.5, 1, 2, 4, 6, 8, 12 h post ingestion. A 1 week washout period used.The coingestion...

Recruitment of lymphocytes is an important feature the host immune response against pathogens. However, mechanisms by which are attracted not yet fully understood. Recently, cDNA a lymphocyte-specific chemokine, lymphotactin (Lptn), was isolated from murine and human T cells also found to be expressed in NK cell clones. This study investigated influence interleukin (IL)-2 IL-12 on expression Lptn, known as SCM (single cysteine motif)-1alpha, SCM-1beta, 97% homolog freshly line NK-92....

We simultaneously measured hepatic insulin removal invasively and estimated clearance extraction of pharmacokinetically from cardiac output peripheral plasma concentrations (relatively) noninvasively. The invasive methods involved continuous electromagnetic measurements portal venous arterial blood flow simultaneous intermittent sampling the veins femoral artery for assay concentrations. noninvasive method assumed that is proportional to a constant fraction total body insulin. In...

Known and possible phenolic primary secondary amine metabolites of lidocaine were added to urine from drug-naive rats. These derivatized in this aqueous medium by acetylation with acetic anhydride or pentafluorobenzoylation pentafluorobenzoyl chloride. The derivatives simultaneously extracted into an organic solvent. products separated gas chromatography (flame ionization detection for acetates electron-capture pentafluorobenzoates) identified combined chromatography/mass spectrometry. Mass...