The chemistry and applications of 2-pyridone structures have recently attracted a lot attention due to their uses as synthetic intermediates biological importance. Furthermore, 2-pyridones are different category pharmacophores that exhibit several activities. Results: substrates synthetically multilateral, where they can be used synthesize wide range heterocyclic compounds drug synthesis raw material. Therefore, it was the purpose this review evaluate pharmacological properties various...

The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon treatment significantly elevated alanine aminotransferase, aspartate alkaline phosphatase gamma glutamyltransferase activities serum triglycerides cholesterol concentration as compared control group. It also increased RBCs counts Hb concentration, total or differential leucocytes counts. However it decreased platelet...

Doxorubicin (DOX) is an anti-neoplastic therapy, but its use limited by deleterious toxic effects including nephrotoxicity and cardiotoxicity. This work aimed at assessing the potential protective effect of Ceratonia siliqua methanol extract (CME) on DOX-induced in 5 groups Wistar rats. Nephrotoxicity was induced experimentally intraperitoneal (IP) injection DOX (15 mg/kg). increased serum creatinine, urea, sodium, potassium levels. It elevated MDA levels renal tissue decreased concentration...

Helicobacter pylori (H. pylori) is a universal health intimidation as mentioned by the World Health Organization. The primary causal agent linked to number of illnesses, including inflammation and development stomach ulcers, pylori. Since, H. develops antibiotic resistance quickly, current treatment approaches are becoming less effective. Our research aims highlight novel formulation antibiotics using CuO-NPs catalysts studied their activity anti-helicobacter supported computational studies...

Little is known about the implications of titanium dioxide nanoparticles (TiO

Two series of benzodioxole-pyrazole hybrids were synthesized and the IC50 values for in vitro inhibition enzymes cyclooxygenase 1/2 (COX-1, COX-2) 5-lipoxygenase (5-LOX) investigated. All compounds tested their vivo anti-inflammatory analgesic potentials using diclofenac sodium as a reference standard. Compounds 4, 11, 17, 20, 21, 26, 27, which showed good and/or activities, also evaluated ability to inhibit tumor necrosis factor (TNF)-α production, myeloperoxidase proteinase, beside...

In the present study, spiro compounds are shown to have distinctive characteristics because of their interesting conformations and structural impacts on biological systems.

Ectoparasites such as fleas and mange, are a significant health concern for dogs, affecting their overall quality of life. This experimental study aimed to evaluate the efficacy Nanoemulsion loaded with ivermectin in treatment dogs infested mange. Seventeen were included trial, divided into three groups: control group seven healthy five suffering from flea infestations, mange infestations. Blood samples collected before at weekly intervals over four weeks assess changes hematological...

ABSTRACT The condensation of 3‐amino‐1H‐1,2,4‐triazole with 2‐benzoyl benzoic acid produced a novel Schiff base ligand (H 2 L). structure synthesized H L and its metal complexes [Co(II), Ni(II), Cu(II), Zr(IV)] were characterized by mass spectrometry, FT‐IR, 1 NMR, XRD, UV‐vis, ESR, TG‐DTG analyses also, supported computational approaches. FT‐IR spectral data showed that acts in tridentate mode through azomethine nitrogen, the nitrogen triazole, carboxylate group oxygen. XRD results...

Abstract The antidiarrhoeal effect of seven plant extracts namely: the aerial parts Euphorbia paralias L. (EP), Bidens bipinnata (BB), Cynachum acutum L . (CyAc), Diplotaxis acris (Forssk.) Boiss (DA), Convolvulus fatmensis (CF) and Schouwia thebaica Webb (ST) leaves Plantago major (PM), was evaluated on castor oil‐induced diarrhoea, gastrointestinal movement in rats (charcoal meal) motility duodenum isolated from freshly slaughtered rabbits. A significant tested against diarrhoea achieved...

Abstract A versatile, efficient, clean, and facile method was used for the synthesis of pyrano[2,3‐ d ]pyrimidine derivatives by one‐pot three‐component condensation reaction thiobarbituric acid malononitrile with p ‐chlorobenzaldehyde, using Fe 3 O 4 or ZnO Mn as nanostructure catalysts. The catalyst could be easily recovered an external magnet reused six cycles almost a consistent activity. series polyheterocyclic compounds containing five and/or rings fused each other designed....

The aqueous and methanolic extracts of Calligonum comosum were investigated for their antioxidant dopaminergic effects on haloperidol (HL)-induced neuro- hepatotoxicities in male albino rat model. total phenolics, flavonoid content free radical-scavenging activity the determined. results showed that extract was higher than one. HL significantly reduced GSH increased MDA brain liver tissues. These values nearly normalized, examined tissues, concomitant administration C. with HL. Superoxide...

<br><b>Objective:</b> To analyze the phytochemical constituents, and to explore potential protective effect of methanol extract <i>Moringa oleifera (M. oleifera)</i> seeds Egyptian propolis, each alone or concurrently administered on acetic acid-induced ulcerative colitis in rats. <b>Methods:</b> Eight groups 5 rats were used: normal control group with distilled water, model group, two <i>M. oleifera</i> (100 200 mg/kg), propolis (50 100 one concurrent administration both, prednisolone...

Chalcones are intent in the daily diet as a favorable chemotherapeutic compound; on other hand thiophene moiety is present large number of bioactive molecules having diverse biological efficiency.Our current goal synthesis (E)-1-(pyridin-3-yl)-3-(thiophen-2-yl) prop-2-en-1-one 3 that's used starting compound to synthesize novel pyrimidine-2-thiol, pyrazole, pyran derivatives. was prepared by condensation 3-acetylpyridine with 2-carboxaldehyde which reacted thiourea obtain pyrimidinthiol...

Selenium containing heterocyclic compounds gained great interest as bioactive molecules of late. This report explores the design, synthesis, characterization, and antimicrobial screening new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system a solvent-free, microwave irradiation environment was employed to afford this series. The spectroscopic techniques were exploited verify structures synthesized derivatives. Additionally, agar diffusion method determine...

The most common species in the Satureja genus is montana (family Lamiaceae). present work aims to use molecular docking study predict isolated constituents against an immune system immunomodulator and tested alcoholic extract as in-vitro immunomodulatory agent.All compound's structures were determined using various chromatographic spectroscopic techniques. Anti-inflammatory antioxidant profiles studied for of plant; was performed compounds (1-4).In this work, four recognized extracted from...