A5063136227- Hearing, Cochlea, Tinnitus, Genetics
- RNA regulation and disease
- Hearing Loss and Rehabilitation
- Mitochondrial Function and Pathology
- Conducting polymers and applications
- CRISPR and Genetic Engineering
Inserm
2023-2024
Institute for Neurosciences of Montpellier
2023-2024
Hôpital Saint Eloi
2024
The disruption of the synaptic connection between sensory inner hair cells (IHCs) and auditory nerve fiber terminals type I spiral ganglion neurons (SGN) has been observed early in several pathologies (e.g., noise-induced or ototoxic drug-induced age-related hearing loss). It suggested that glutamate excitotoxicity may be an inciting element degenerative cascade these pathological cochlear conditions. Moreover, oxidative damage induced by free hydroxyl radicals nitric oxide dramatically...
Abstract Dominant optic atrophy (DOA) is one of the most prevalent forms hereditary neuropathies and mainly caused by heterozygous variants in OPA1 , encoding a mitochondrial dynamin-related large GTPase. The clinical spectrum DOA has been extended to wide variety syndromic presentations, called plus including deafness as main secondary symptom associated vision impairment. To date, pathophysiological mechanisms underlying remain unknown. gain insights into process leading hearing...