A5084277309- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Connective tissue disorders research
- Intracranial Aneurysms: Treatment and Complications
- Ubiquitin and proteasome pathways
- Alcohol Consumption and Health Effects
- Algal biology and biofuel production
- Enzyme Production and Characterization
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Catalytic Cross-Coupling Reactions
- Dendrimers and Hyperbranched Polymers
- Biocrusts and Microbial Ecology
- Alkaloids: synthesis and pharmacology
- Intracerebral and Subarachnoid Hemorrhage Research
- Skin and Cellular Biology Research
- Antimicrobial agents and applications
- Biopolymer Synthesis and Applications
- Molecular Sensors and Ion Detection
- Antimicrobial Peptides and Activities
- Moyamoya disease diagnosis and treatment
- Chemical synthesis and alkaloids
- Luminescence and Fluorescent Materials
- Cellular Mechanics and Interactions
Sophia University
2018-2025
Fluorescence recognition of d-glucose in water with excellent sensitivity, selectivity, and chiral selectivity is desired because an essential component biological pathological processes. We report innovative approach that exploits the 1:2 stoichiometric inclusion complexes γ-cyclodextrin (γ-CyD) two molecules fluorescent monoboronic acid-based receptors, which form a pseudo-diboronic acid moiety as site for water. Two acids (1F 2N) were easily synthesized without heating or column...
The need for a selective bacterial recognition method is evident to overcome the global problem of antibiotic resistance. Even though researchers have focused on boronic acid-based nanoprobes that immediately form boronate esters with saccharides at room temperature, mechanism has not been well studied. We developed acid-modified poly(amidoamine) (PAMAM) dendrimers various surface properties investigate recognition. showed selectivity toward strains, species, or certain group bacteria by...
This study reports a novel, fast, easy, and sensitive detection method for bacteria which is urgently needed to diagnose infections in their early stages. Our work presents complex of poly(amidoamine) dendrimer modified by phenylboronic acid labeled fluorescent dansyl group (Dan-B8.5-PAMAM). system detects 20 min with sensitivity approximately 104 colony-forming units (CFU)·mL−1. Moreover, it does not require any peculiar technical skills or expensive materials. The driving force recognition...
We have developed a convenient and selective method for the detection of Gram-positive bacteria using ditopic poly(amidoamine) (PAMAM) dendrimer probe. The that was modified with dipicolylamine (dpa) phenylboronic acid groups showed selectivity toward Staphylococcus aureus. system had higher sensitivity better pH tolerance than monotopic PAMAM also investigated mechanisms various probes found dependent on variety interactions. Supramolecular interactions, such as electrostatic interaction...
Established isotope-dilution LC-MS/MS method suggested that desmosines can be regarded as biomarkers of acute cerebral stroke.
Desmosine and isodesmosine are crosslinking amino acids of elastin, which is an essential component the dermal extracellular matrix protein. Quantitative analysis crosslinker desmosines in human skin dermis has not been fully achieved due to insoluble nature elastin In present study, chemical synthesis isotopically labeled desmosine, desmosine-13C3,15N1, was carried out via isoChichibabin pyridinium starting from corresponding acids. Isotope-dilution LC-MS/MS desmosine utilizing synthetic...
Antimicrobial-resistant (AMR) bacteria have become a critical global issue in recent years. The inefficacy of antimicrobial agents against AMR has led to increased difficulty treating many infectious diseases. Analyses the environmental distribution are important for monitoring problem, and rapid as well viable pH- temperature-independent bacterial separation method is required collecting concentrating from samples. Thus, we aimed develop useful selective using chemically synthesized...
Abstract We chemically synthesized an isotopically labeled internal standard, isodesmosine- 13 C 3 , 15 N 1 and established isotope-dilution LC-MS/MS method. Plasma concentrations of desmosine isodesmosine in acute cerebral stroke patients healthy controls were determined. The concentration was markedly higher plasma from compared with controls. Desmosines are novel biomarkers for evaluating the extent vascular injury after stroke.