A5080772668- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Advanced Materials and Mechanics
- Hydrogels: synthesis, properties, applications
- Aortic aneurysm repair treatments
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Aortic Disease and Treatment Approaches
- Cellular Mechanics and Interactions
- Graphene and Nanomaterials Applications
University of Chicago
2021
Illinois Institute of Technology
2018-2020
Biomaterial strategies focused on designing scaffolds with physiologically relevant gradients provide a promising means for elucidating 3D vascular cell responses to spatial and temporal variations in matrix properties. In this study, we present photopolymerization approach, ascending photofrontal free-radical polymerization, generate proteolytically degradable hydrogel of poly(ethylene) glycol tunable continuous (1) elastic modulus (slope 80 Pa/mm) uniform immobilized RGD concentration...
Abstract Gradients in mechanical properties, physical architecture and biochemical composition exist a variety of complex tissues, yet 3D vitro models that enable investigation these cues on cellular processes, especially those contributing to vascularization engineered tissues are limited. Here, photopolymerization approach create cell‐laden hydrogel biomaterials with decoupled combined gradients modulus, immobilized cell adhesive peptide (RGD) concentration, proteolytic degradation...
Insufficient vascularization limits the volume and complexity of engineered tissue. The formation new blood vessels (neovascularization) is regulated by a complex interplay cellular interactions with biochemical biophysical signals provided extracellular matrix (ECM) necessitating development biomaterial approaches that enable systematic modulation in properties. To address this need poly(ethylene) glycol-based hydrogel scaffolds were range decoupled combined variations integrin-binding...
Tissue-engineered vascular grafts (TEVGs) require adequate extracellular matrix (ECM) to withstand arterial pressure. Tissue transglutaminase (TG2) and lysyl oxidase (LOX) are enzymes that cross-link ECM proteins play a pivotal role in the development of stiffness associated with aging. The purpose this study is investigate expression cross-linking mechanisms scaffold degeneration leading TEVG remodeling. Fast- slow-degrading electrospun TEVGs were fabricated using polydioxanone (PDO)...
Tissue response to intestinal injury or disease releases pro-inflammatory host stress signals triggering microbial shift pathogenic phenotypes.
In articule number 2001706 by Georgia Papavasiliou and co-workers, vascular cell-laden gradient PEG hydrogels with five types of combinations including immobilized cell adhesion peptide concentration (RGD), stiffness, protease-sensitivity are designed to investigate their role on spatial variations in sprouting responses 3D culture.