Hélder Pinheiro

ORCID: 0000-0001-6076-2670
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About
Contact & Profiles
Research Areas
  • Protein Hydrolysis and Bioactive Peptides
  • Receptor Mechanisms and Signaling
  • Renin-Angiotensin System Studies
  • Consumer Attitudes and Food Labeling
  • Coal Properties and Utilization
  • Hormonal Regulation and Hypertension
  • Hydrocarbon exploration and reservoir analysis
  • Food composition and properties
  • Gut microbiota and health
  • Geochemistry and Geologic Mapping
  • Atmospheric and Environmental Gas Dynamics
  • Methane Hydrates and Related Phenomena
  • Clostridium difficile and Clostridium perfringens research
  • Intensive Care Unit Cognitive Disorders
  • Combustion and Detonation Processes
  • Biochemical effects in animals
  • Adipose Tissue and Metabolism
  • Peroxisome Proliferator-Activated Receptors
  • Food Science and Nutritional Studies
  • Apelin-related biomedical research
  • Mineral Processing and Grinding
  • Insect Utilization and Effects
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Poxvirus research and outbreaks
  • Herpesvirus Infections and Treatments

Hospital Curry Cabral
2016-2024

Universidade Nova de Lisboa
2018-2023

Centro Hospitalar de Lisboa Central
2016-2022

Colorado School of Mines
2022

Centro Hospitalar do Baixo Vouga
2021

Hospital de Egas Moniz
2021

Instituto Politécnico de Santarém
2021

University of Lisbon
2019

Office of Infectious Diseases
2019

Nova Medical (United States)
2019

The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of gut microbiota on host immune and inflammatory functions, we investigated association between changes in composition clinical COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), (2) location...

10.3389/fmicb.2021.705020 article EN cc-by Frontiers in Microbiology 2021-07-19

Monkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central Western Africa for decades. More recently, an outbreak spread to global level, occurring sites with no previous reported cases being clustered among men who have sex men, suggesting new modes of transmission. There is urgent need research better understanding the genomic evolution changing epidemiology Orthopoxvirus group. Our work aimed characterize clinical...

10.3390/idr14060083 article EN cc-by Infectious Disease Reports 2022-10-27

We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course disease resembles progressive vaccinia, formerly reported caused by uncontrolled replication smallpox vaccination orthopoxviruses immunosuppressed patients. Severe small bowel jeopardized normal oral...

10.3390/idr15020018 article EN cc-by Infectious Disease Reports 2023-03-16

The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods.

10.1039/c6fo00030d article EN Food & Function 2016-01-01

Abstract The physiological function of alkaline phosphatase (ALP) remains controversial. It was recently suggested that this membrane‐bound enzyme has a role in the modulation transmembranar transport systems into hepatocytes and Caco‐2 cells. ALP activity expressed on apical surface blood‐brain barrier cells, its relationship with 125 I‐insulin internalization were investigated under conditions using p ‐nitrophenylphosphate ( ‐NPP) as substrate. For this, an immortalized cell line rat...

10.1002/jcb.10027 article EN Journal of Cellular Biochemistry 2001-12-06

Introduction Cardiovascular diseases (CVD) are the leading cause of mortality worldwide and diet is an important contributor to CVD risk. Thus, several food derivatives being investigated for their beneficial impact on reducing cardiometabolic risk factors, either in groups or healthy population as a preventive measure. Wheat germ by-product with high nutritional value, especially concentrated source dietary fibre essential fatty acids, but its incorporation into has been rare up now....

10.1136/bmjopen-2016-013098 article EN cc-by-nc BMJ Open 2016-11-01

Abstract Risk factors for COVID-19 disease severity are still poorly understood. Considering the pivotal role of gut microbiota on host immune and inflammatory functions, we investigated association between changes in composition clinical COVID-19. We conducted a multicentre cross-sectional study prospectively enrolling 115 patients categorized according to: 1) WHO Clinical Progression Scale - mild 19 (16.5%), moderate 37 (32.2%) or severe 59 (51.3%); 2) location recovery from ambulatory 14...

10.1101/2021.04.20.440658 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2021-04-23

Intake of whole grains is associated with a reduced risk cardiovascular disease (CVD). This evidence also strong for bran alone, but findings about germ are conflicting. Our aim was to elucidate the role in primary prevention events, and therefore, staple food selected 6 g supplementation. corresponds sixfold increase global mean consumption germ, while preserving sensory proprieties refined bread which crucial consumer's acceptance.Randomised, double-blinded, crossover, controlled clinical...

10.1136/bmjopen-2018-023662 article EN cc-by-nc BMJ Open 2019-01-01
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