A5106708837- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Poxvirus research and outbreaks
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- COVID-19 and Mental Health
- Women's cancer prevention and management
- Fungal Infections and Studies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Sports Analytics and Performance
- Enterobacteriaceae and Cronobacter Research
- Virus-based gene therapy research
- Skin Diseases and Diabetes
- COVID-19 diagnosis using AI
Hospital Curry Cabral
2013-2024
Centro Hospitalar de Lisboa Central
2013-2024
Instituto Gulbenkian de Ciência
2023-2024
University of Oxford
2021
Universidade do Porto
2013
Hospital de São João
2013
Recent studies have shown that persistent SARS-CoV-2 infections in immunocompromised patients can trigger the accumulation of an unusual high number mutations with potential relevance at both biological and epidemiological levels. Here, we report a case patient (non-Hodgkin lymphoma under immunosuppressive therapy) infection (marked by intermittent positivity) over least 6 months. Viral genome sequencing was performed days 1, 164, 171 to evaluate evolution. Among 15 single-nucleotide...
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters investigate their relationships. Here, we combine genomic epidemiological data of the 2022 mpox outbreak better early viral spread, diversification transmission dynamics. By 52% confirmed cases in Portugal, identified virus sublineages with highest impact on case numbers fitted them into a global context, finding evidence that several international probably emerged or spread...
Monkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central Western Africa for decades. More recently, an outbreak spread to global level, occurring sites with no previous reported cases being clustered among men who have sex men, suggesting new modes of transmission. There is urgent need research better understanding the genomic evolution changing epidemiology Orthopoxvirus group. Our work aimed characterize clinical...
We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course disease resembles progressive vaccinia, formerly reported caused by uncontrolled replication smallpox vaccination orthopoxviruses immunosuppressed patients. Severe small bowel jeopardized normal oral...
Information about pan-genotypic treatments for hepatitis in Portugal is scarce. We aimed to evaluate the effectiveness and safety of glecaprevir plus pibrentasvir (GLE/PIB) treatment C virus (HCV) infection real-world clinical practice.
Integrase strand transfer inhibitor-based regimens are recommended for first-line therapy in human immunodeficiency virus type 2 (HIV-2). Nonetheless, dolutegravir (DTG) clinical trial data lacking.We conducted a phase 2, single-arm, open-label to evaluate the safety and efficacy of triple regimen that included DTG persons with HIV-2 (PWHIV-2) Portugal. Treatment-naive adults receive combination nucleoside reverse transcriptase inhibitors (NRTIs). Treatment was evaluated by proportion...
Introduction: Tuberculosis incidence in Portugal ranged from 20 to 22 cases per 100 000 inhabitants between 2010 and 2014. liver transplant recipients is not precisely known, but it estimated be higher than among the general population. particularly challenging because of atypical clinical presentation side effects antibacillary drugs their potential interactions with immunosuppressive therapies.Material Methods: We retrospectively reviewed records post-transplant tuberculosis occurring...
Carbapenem-resistant Enterobacteriaceae (CRE) epidemiology among liver transplant (LT) recipients is variable. We studied the impact of CRE colonization and infection on LT recipients' outcomes. This observational cohort study included consecutive adult between January 2019 December 2020 at Curry Cabral Hospital, Lisbon, Portugal. Primary exposures were (rectal swabs under a screening program) within 1 year index LT. endpoint was graft failure Among 209 patients, median (interquartile range...
In 2023, a second wave of the global mpox epidemic, which is mainly affecting men who have sex with (MSM), was observed in some countries. Herein, we benefited from large viral sequence sampling (76/121; 63%) and vast epidemiological data to characterise re-emergence circulation
Introdução: As estirpes de Mycobacterium tuberculosis da família Beijing estão associadas à multirresistência. Lisboa prevalecem entre os doentes com tuberculose multirresistente e extensivamente resistente desta região, mas vários estudos documentam a presença Beijing, embora desconhecendo-se as características dos donde foram isoladas.Material Métodos: Estudo retrospectivo 104 multirresistentes resistentes tuberculosis, isoladas genotipadas, 1993 2015, igual número Lisboa. Avaliámos...
Background: Although endemic in West Africa, HIV-2 infection dissemination is limited to about 1.2 million people worldwide.However, the prevalence of Portugal disproportionately high, similarly other countries with strong socioeconomic ties African former colonies.Due intrinsic resistance non-nucleoside reverse transcriptase inhibitors (non-NRTIs) and enfuvirtide, along reduced susceptibility several protease (PI), antiretroviral therapy (ART) relies on a regimen containing two NRTIs...
Bacillus Calmette-Guérin (BCG) is a live attenuated form of Mycobacterium bovis, initially used in medicine as vaccination agent only. The discovery its antineoplastic effects bladder cancer has led to the widespread recognition BCG intravesical instillation therapeutic option. Although sepsis following rare, it nonetheless dreadful and potentially fatal complication. Therapy usually relies on antituberculous therapy steroids, alongside with intensive care unit admission. authors report case...
There have been several reports of tuberculosis (TB) and, less frequently, nontuberculous mycobacterial (NTM) infections in association with tumor necrosis factor α inhibitor (anti-TNFα) therapy. Mycobacterium marinum is a NTM distinct epidemiology and infrequently responsible for disease humans. Most commonly, it causes localized skin infections, but 20% to 40% cases, involves deeper structures. Disseminated exceptional has reported occur only immunocompromised patients. The authors report...
Introdução: Os homens que têm sexo com homens, particularmente os infectados pelo vírus da imunodeficiência humana (VIH) risco aumentado de cancro anal. Ao contrário maior parte das doenças oportunistas e/ou definidoras SIDA, dados são contraditórios no diz respeito ao efeito terapêutica antirretrovírica, não sendo claro o impacto supressão virológica e reconstituição imunitária na evolução infecção por do papiloma humano (HPV) prevenção neoplasias associadas. Actualmente é já recomendada a...
N/a
Background: Simultaneous central nervous system infection by more than one pathogen is very uncommon, even in individuals with acquired immunodeficiency syndrome. Purpose and methods: We report a clinical case of an HIV positive patient simultaneous biopsy-confirmed neurotoxoplasmosis neurocysticercosis. Results conclusion: In this report, we present rare occurrence two parasitic infections the advanced immunosuppression due to HIV-1 infection. Despite limited data available regarding...
Introdução: Os homens que têm sexo com (HSH), particularmente os infectados pelo vírus da imunodeficiência humana (VIH) maior risco aumentado de cancro anal. factores para esta neoplasia incluem prevalência infecção do canal anal papiloma humano (HPV), incluindo aumento frequência por múltiplos tipos HPV alto nesta população, idade avançada e menor clearance vírico associado à imunossupressão. Ao contrário partes dos eventos oportunistas e/ou definidores SIDA, dados são contraditórios no diz...
Background: The increasing use of immunomodulatory therapies has motivated the development strategies to assess and prevent infectious diseases in these immunosuppressed patients, whom risk serious infections is higher. Objectives: aim this study was recognize need standardize prophylactic therapeutic population. Methods: Retrospective review clinical files patients evaluated assessment an outpatient clinic at Infectious Diseases Unit Hospital de Curry Cabral Lisbon, between June 2016...
Immunosuppressive drugs are the cornerstone of treatment auto-immune inflammatory diseases (AIIDs) with renal involvement. How‑ ever, most commonly used in this setting can increase risk bacterial, fungal, and viral infection, also impair immune response following vaccination. Recommendations evidence on strategies for infection prevention AIIDs will be reviewed.