A5064797857- Adolescent and Pediatric Healthcare
- Connective tissue disorders research
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Pregnancy and preeclampsia studies
- Eosinophilic Esophagitis
- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Bone fractures and treatments
- Bone health and treatments
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Endometriosis Research and Treatment
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Cardiovascular Issues in Pregnancy
- Hypothalamic control of reproductive hormones
- Apelin-related biomedical research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiomyopathy and Myosin Studies
- FOXO transcription factor regulation
Washington University in St. Louis
2017-2025
Shriners Hospitals for Children - St. Louis
2020-2024
University of Missouri Health System
2020-2022
University of Missouri
2015-2020
Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally affects individuals with obesity. The mechanisms by which obesity leads to onset progression OA are unclear due complex interactions among metabolic, biomechanical, inflammatory factors that accompany increased adiposity. We used a murine preclinical model lipodystrophy (LD) examine direct contribution adipose tissue OA. Knee joints LD mice were protected from spontaneous or posttraumatic OA, on either...
Glycine (Gly) substitutions in collagen Gly-X-Y repeats disrupt folding of type I procollagen triple helix and cause severe bone fragility malformations (osteogenesis imperfecta [OI]). However, these mutations do not elicit the expected endoplasmic reticulum (ER) stress response, contrast to other protein-folding diseases. Thus, it has remained unclear whether cell osteoblast malfunction contribute pathology caused by Gly substitutions. Here we used a mouse with Gly610 cysteine (Cys)...
Recurrent pregnancy loss (RPL), characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition embryo quality and endometrial function, proper oviduct function is also essential for successful establishment. Therefore, structural abnormalities inflammation resulting from infection in the may impede transport of embryos endometrium, thereby increasing risk miscarriage. However, our understanding biological processes that preserve...
Recurrent pregnancy loss, characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition embryo quality and endometrial function, proper oviduct function is also essential for successful establishment. Therefore, structural abnormalities inflammation resulting from infection in the may impede transport of embryos endometrium, thereby increasing risk miscarriage. However, our understanding biological processes that preserve...
Abstract Uterine receptivity is critical for establishing and maintaining pregnancy. For the endometrium to become receptive, stromal cells must differentiate into decidual capable of secreting factors necessary embryo survival placental development. Although there are multiple reports autophagy induction correlated with endometrial cell (ESC) decidualization, role in decidualization has remained elusive. To determine we utilized 2 genetic models carrying mutations gene Atg16L1. hypomorphic...
Abstract Successful establishment of pregnancy depends on steroid hormone-driven cellular changes in the uterus during peri-implantation period. To become receptive to embryo implantation, uterine endometrial stromal cells (ESCs) must transdifferentiate into decidual that secrete factors necessary for survival and trophoblast invasion. Autophagy is a key homeostatic process vital homeostasis. Although undergoes major early pregnancy, precise role autophagy function unknown. Here, we report...
Abstract Osteogenesis imperfecta (OI) is a heterogeneous heritable connective tissue disorder associated with reduced bone mineral density and skeletal fragility. Bone inherently mechanosensitive, strength being proportional to muscle mass strength. Physically active healthy children accrue more than inactive children. Children type I OI exhibit decreased exercise capacity compared peers. It unknown whether this weakness reflects physical activity or pathology. In study, we used heterozygous...
Leptin is required for fertility, including initiation of estrous cycles. It therefore challenging to assess the role leptin signaling during pregnancy. Although neuron-specific transgene approaches suggest that in central nervous system most important, experiments with pharmacologic inhibition uterus or global replacement pregnancy reproductive tract may be required. Here, conditional receptor knockout (Lepr cKO) a progesterone receptor-driven Cre recombinase was used examine importance...
Abstract Osteoarthritis (OA) is a prevalent aging disorder of synovial joints and recent work suggests that parental high‐fat diet increases OA severity following joint injury in offspring. We hypothesized maternal high‐sugar (HFHS) would promote spontaneous osteoarthritis‐related cartilage bone changes 1‐year‐old Female C57BL/6 J mice were placed on either chow control or HFHS for 6 weeks before mating to chow‐fed male maintained their assigned diets throughout pregnancy lactation. Male...
Significance Osteogenesis imperfecta (brittle bone disease) is an incurable genetic disorder. We demonstrate that maternal deficiency of myostatin (a negative regulator muscle growth) can enhance biomechanical strength and integrity in control osteogenesis mouse offspring, using three independent approaches. provide evidence responsive to developmental programming mediate these effects. Embryo transfer experiments show the effects are conferred by postimplantation environment. These studies...
Mucopolysaccharidosis type I (MPS I), is an autosomal recessive lysosomal storage disorder caused by a deficiency in the α-L-iduronidase enzyme, resulting decreased enzymatic activity and accumulation of glycosaminoglycans. The phenotypically manifests with increased urine glycosaminoglycan excretion, facial dysmorphology, neuropathology, cardiac manifestations, bone deformities. While development new treatment strategies have shown promise attenuating many symptoms associated disorder,...
Abstract The prevalence of maternal obesity is increasing at an alarming rate and increases the life-long risk developing cardiometabolic disease in adult offspring. Leptin, adipokine, systemically elevated obese milieu. We recently showed that hyperleptinemia without improves offspring insulin sensitivity glucose tolerance while protecting against weight gain on a high-fat, high-sugar (HFD). Here, we investigate effect bone by using 2 independent models. First, compared wild-type (WT) from...
Recurrent pregnancy loss (RPL), characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition embryo quality and endometrial function, proper oviduct function is also essential for successful establishment. Therefore, structural abnormalities inflammation resulting from infection in the may impede transport of embryos endometrium, thereby increasing risk miscarriage. However, our understanding biological processes that preserve...
Recurrent pregnancy loss (RPL), characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition embryo quality and endometrial function, proper oviduct function is also essential for successful establishment. Therefore, structural abnormalities inflammation resulting from infection in the may impede transport of embryos endometrium, thereby increasing risk miscarriage. However, our understanding biological processes that preserve...