A5015047415- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Vanadium and Halogenation Chemistry
- Catalytic Alkyne Reactions
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Complementary and Alternative Medicine Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemistry and Biological Activities
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis of Tetrazole Derivatives
- Essential Oils and Antimicrobial Activity
- Organometallic Complex Synthesis and Catalysis
- Click Chemistry and Applications
- Microbial Natural Products and Biosynthesis
- Multicomponent Synthesis of Heterocycles
- Synthesis of Organic Compounds
- Pharmacology and Obesity Treatment
- Alkaloids: synthesis and pharmacology
Universidad de Guanajuato
2016-2025
Wyoming Department of Education
2021
University of Wyoming
2021
Northeast Normal University
2021
Shanghai Institute of Organic Chemistry
2021
Benemérita Universidad Autónoma de Puebla
2021
Loughborough University
2021
University of Pittsburgh
2021
Hunan University of Technology
2021
Universidad Michoacana de San Nicolás de Hidalgo
2021
Cationic gold(I) promotes the retro-Buchner reaction of 7-substituted 1,3,5-cycloheptatrienes, leading to carbenes that cyclopropanate alkenes.
The gold(I)-catalyzed cyclization of 1-(prop-2-yn-1-yl)-2-alkenylbenzenes substituted at the benzylic position with OR groups gives 1,3-disubstituted naphthalenes concomitant fragmentation alkene. One these annulations proceeds by a retro-cyclopropanation that leads to free gold(I) carbenes.
The frog prince with his two identities pales in comparison the shape-shifting barbaralyl cation, which exists as a mixture of 181 400 degenerate forms. Gold-catalyzed cycloisomerizations 7-alkynyl cyclohepta-1,3,5-trienes were found to proceed via fluxional intermediates (see scheme). evolution into 1- or 2-substituted indenes could be controlled by choice gold complex.
A practical electrophilic bromination procedure for the phenolic core was developed under efficient and very mild reaction conditions. The new I(iii)-based brominating reagent<bold>PhIOAcBr</bold>operationally easy to prepare by mixing PIDA AlBr<sub>3</sub>was used.
This study evaluated the inhibitory effect of myristic acid (MA) on models inflammation and nociception. The in vitro anti-inflammatory activities MA were assessed LPS-stimulated macrophages, membrane stabilization assay, inhibition protein denaturation, whereas activity vivo was TPA-induced ear edema using acute chronic assays mice. nociception three models. exerted by increase (58%) production IL-10 macrophages. In showed good effects (ED50 = 62 mg/kg) 77 edema. antinociceptive related to...
Iodine(III) reagents became a highly relevant tool in organic synthesis due to the great versatility as strong but green oxidants. Several transformations involving cyclizations well functionalization of different cores have been broadly described and reviewed. Herein new facet which involves participation these photochemical exclusively by direct irradition or photoredox cycles using some transition metals, will be briefly plausible further that potentially can developed.
This work assessed the antioxidant, antimicrobial, genotoxic, acute toxicity, antidiarrheal, antinociceptive, and anti‐inflammatory effects of an ethanolic extract from Catasetum integerrimum pseudobulbs (CIE). The antidiarrheal activity CIE (1–100 mg/kg p.o.) was with castor oil‐related tests. estimated using 12‐O‐Tetradecanoylphorbol‐13‐acetate (TPA) ear‐induced edema. exerted (ED50 = 2.0 in oil‐induced diarrhea model inhibited intestinal fluid accumulation. Three models demonstrated...
Self-medication during pregnancy represents a serious threat for mother and child health. The objective of this study was to evaluate the prevalence factors associated with self-medication among Mexican women living in central region Mexico. This is descriptive interview-study 1798 pregnant or who were no more than 3 years ago, when interview carried out. Data analysis out chi-square odds ratio. (allopathic drugs, medicinal plants, other products, including vitamins, food supplements,...
A new and in situ formed reagent generated by mixing PIFA {bis[(trifluoroacetoxy)iodobenzene]} AlCl 3 was introduced the organic synthesis for direct highly regioselective ortho ‐chlorination of phenols phenol ethers. An efficient electrophilic chlorination these electron‐rich arenes as well scope reaction are described herein. easy, practical, open‐flask allowed us to introduce a chlorine atom, which is important functional group synthesis. The reproducibility our method has been...
An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide cheap iodine atom source. A totally controlled monoiodination achieved buffering reaction medium with K3PO4. This protocol proceeds short times, at mild temperatures, in an open flask, generally high yields. Gram-scale reactions, well scope this protocol, were explored electron-rich electron-poor heterocycles. Quantum chemistry...
A catalytic, practical and high-yielding procedure for the synthesis of indenes by direct Csp3-H activation under gold(i) catalysis was developed. The scope protocol determined synthesizing some electron-neutral, electron-poor as well electron-rich derivatives including dibenzofurane carbazole heterocycles. mechanism this reaction elucidated theoretical calculations using a ONIOM(M08-HX/mixed-basis:PM6) hybrid scheme. Thereby we found pericyclic transformation involving [1,5]-H shift...
The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate a nitro group source. This atom-economic protocol occurs under mild, non-Brønsted acidic open-flask reaction conditions with broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G*) level indicated that proceeds through cationic...
The first gold(I)-catalyzed cycloisomerization procedure applied to the synthesis of substituted 4H-benzo[d][1,3]oxazines has been developed starting from N-(2-alkynyl)aryl benzamides. chemoselective oxygen cyclization via 6-exo-dig pathway yielded observed heterocycles in modest good chemical yields under very mild reaction conditions. obtained oxazines were assayed on breast cancer (BC)-derived cell lines MCF-7 and HCC1954 with differential biological activity. newly synthesized...
Abstract The first iodine(III)‐mediated para ‐selective iodination protocol for free anilines as well the mechanistic elucidation of reaction pathway is described. developed method proceeded under clean, non‐toxic, efficient, and in general mild conditions. To best our knowledge this report describes time a procedure focused specifically on introduction an iodine atom using PIDA [(diacetoxyiodo)benzene] ammonium iodide which formed situ acetyl hypoiodite (AcO‐ I ) halogenating species. Our...
The chemoselective reaction of the C- followed by O-centered naphthyl radicals with more electron-deficient hypervalent bond diaryliodonium(III) salts is described. This discovered reactivity constitutes a new activation mode which enabled one-pot doubly arylation naphthols through sequential Csp2-Csp2/O-Csp2 formation. were generated in tetramethylpiperidinyl radical (TMP·) resulted from homolytic fragmentation precursor TMP2O. Experimental and DFT calculations provided complete panorama mechanism.
The modular protecting-group-free total synthesis of 3-methylkealiiquinone, an analogue the marine alkaloid kealiiquinone, was accomplished in seven steps. A regioselectively constructed functionalized arylbenzimidazolone moiety and dimethyl squarate were used as only two building blocks. thermal ring expansion via 6π-conrotatory closure to build quinone fragment gave rise desired linear natural compound along with a nondescribed structurally attractive angular naphtho[1,2-d]imidazole...
The first iodine(III)-based procedure for the benzylic oxidation of different arenes is described by using (PhIO)n/Al(NO3)3 system under catalytic conditions leading to formation corresponding carbonyl derivatives. method proceeds mild, operationally simple, room temperature, short reaction times, and open flask conditions. In light organocatalysis relevance novelty our protocol, we wish communicate initial results this novel oxidation.