A5042904643- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Biological Activities
- Inflammatory mediators and NSAID effects
- Complementary and Alternative Medicine Studies
- Sesquiterpenes and Asteraceae Studies
- Pharmacology and Obesity Treatment
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Anesthesia and Pain Management
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Biological and pharmacological studies of plants
- Medicinal Plant Extracts Effects
- Alkaloids: synthesis and pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Oral microbiology and periodontitis research
- Veterinary Pharmacology and Anesthesia
- Antibiotics Pharmacokinetics and Efficacy
- Dental Radiography and Imaging
- Porphyrin and Phthalocyanine Chemistry
- Cancer Treatment and Pharmacology
Universidad de Guanajuato
2016-2025
Heilongjiang Bayi Agricultural University
2020
Universidad Autónoma Metropolitana
2015
Polytechnic University of San Luis Potosí
2013
Autonomous University of San Luis Potosí
2012
Background: Combining antinociceptive drugs with different mechanisms of action can reduce the doses and adverse effects, a possible increase in effect. This work evaluated effect combination an ethanol extract Justicia spicigera (JSE) naproxen (NPX) or tramadol (TML) using formalin test rats. Methods: Rats received JSE (30–200 mg/kg p.o.), NPX (50–300 TML (5–50 p.o.) 60 min before paw administration (5%). Different proportions between JSE, as well were used to obtain dose–response curve...
Self-medication during pregnancy represents a serious threat for mother and child health. The objective of this study was to evaluate the prevalence factors associated with self-medication among Mexican women living in central region Mexico. This is descriptive interview-study 1798 pregnant or who were no more than 3 years ago, when interview carried out. Data analysis out chi-square odds ratio. (allopathic drugs, medicinal plants, other products, including vitamins, food supplements,...
A new and in situ formed reagent generated by mixing PIFA {bis[(trifluoroacetoxy)iodobenzene]} AlCl 3 was introduced the organic synthesis for direct highly regioselective ortho ‐chlorination of phenols phenol ethers. An efficient electrophilic chlorination these electron‐rich arenes as well scope reaction are described herein. easy, practical, open‐flask allowed us to introduce a chlorine atom, which is important functional group synthesis. The reproducibility our method has been...
Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, peaking between 6 and 8 when a conventional local anesthetic is used. Dental largely inflammatory, evidence-based medicine shown that nonsteroidal anti-inflammatory drugs are best analgesics for dental pain. The aim this study was compare analgesic, anti-trismus effect single dose diclofenac meloxicam molar extraction.A total 36 patients...
In this work, we demonstrated the regulation of glucose transporters by hypoxia inducible factor-1α (HIF-1α) activation in renal epithelial cells. LLC-PK1 monolayers were incubated for 1, 3, 6, or 12 h with 0% 5% O2 300 μm cobalt (CoCl2). We evaluated effects on mRNA and protein expression HIF-1α SGLT1, SGLT2, GLUT1. The data showed an increase under three conditions (p < 0.05 versus t = 0). An GLUT1 (12 h) (at was observed SGLT1 SGLT2 decreased conclusion, our results suggest a clear...
Abstract Nitrogen‐containing drugs represent one of the worldwide most extensive sources treatments for different diseases. Indomethacin as example, is important non‐steroidal anti‐inflammatories (NSAID) indol‐containing drug. Its relevance has been demonstrated last 50 years with excellent pharmacological results. efficacy an anti‐inflammatory treatment, inspired us exploration structurally less elaborated compounds which kept and/or improve activity compared indomethacin. Herein summarized...
Abstract Preclinical Research The aim of the present study was to evaluate antinociceptive and sedative activity an ethanol extract Justicia spicigera evergreen used in Mexican traditional medicine for relief pain, wounds, fever inflammation. At 200 mg/kg po, maximum dose examined, J. (JSE) had analgesic mice acetic acid writhing test, second phase formalin test tail flick that similar efficacy NSAID, naproxen (150 po). JSE inactive hot plate ketamine‐induced sleeping time test; it no...
Tagetes parryi is a plant empirically used to treat gastrointestinal and inflammatory diseases, its essential oil (EOTP) was obtained from the aerial parts, composition elucidated by GC-MS. The in vivo vitro anti-inflammatory activities antinociceptive activity of EOTP (1S)-(-)-verbenone (VERB) were assessed. major compounds identified for verbenone (33.39%), dihydrotagetone (26.88%), tagetone (20.8%). VERB diminished ear oedema induced with TPA 93.77 % 81.13 %, respectively. decreased...
The aim was to evaluate the diuretic and neuropharmacological actions of d-pinitol describe a possible mechanism action. effects were evaluated using mice placed in metabolic cages. sedative, anxiolytic-like, antidepressant-like, anticonvulsant 1–100 mg/kg assessed. mechanisms action inhibitors. lacked effects. However, showed highest anxiolytic-like (ED50 = 70 p.o. mice) cylinder exploratory test antidepressant-like activity forced swimming 26 mice). (100 mg/kg) exerted...
Iodine(III)-based reagents have been broadly used in oxidative reactions for structural functionalization with several functional groups. Among the more relevant and useful synthetic transformations using these hypervalent λ 3 -reagents, fluorination, chlorination, bromination, as well iodination protocols, can be found. Herein, we present some of most representative halogenation procedures arenes, olefins alkynes dating from oldest to recent advances area, highlighting discovery application...
ABSTRACT Preclinical Research The aim of the present study was to evaluate antinociceptive interaction between naproxen and glycoside flavonoid, rutin in acetic acid‐induced writhing test mice. Naproxen (5, 20, 50, 100 mg/kg p.o.) or (10, 25, 100mg/kg were administered 60 min before intraperitoneal administration with acid. dose‐response curve each individual compound experimental effective dose 50 (ED ) value obtained determinate different proportions combinations two compounds...
Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from tiliifolia. in vitro anti-inflammatory effects TFD (0.1-200 µM) were assessed using murine macrophages stimulated with LPS estimating levels pro-inflammatory mediators 48 h. vivo activity carrageenan-induced paw edema test 6 antinociceptive evaluated formalin acetic acid induced-writhing test. on locomotor open field rotarod inhibited...