A5058649551- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Renal and related cancers
- RNA Interference and Gene Delivery
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Reproductive Biology and Fertility
- CAR-T cell therapy research
- DNA Repair Mechanisms
- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- Immunodeficiency and Autoimmune Disorders
- Microtubule and mitosis dynamics
- Animal Disease Management and Epidemiology
- Molecular Biology Techniques and Applications
- Renal cell carcinoma treatment
- Intestinal Malrotation and Obstruction Disorders
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Congenital gastrointestinal and neural anomalies
- Animal Genetics and Reproduction
University of Helsinki
2015-2024
University of Toronto
2020-2021
Canada Research Chairs
2021
Sunnybrook Research Institute
2020
Sunnybrook Health Science Centre
2020
Sunnybrook Hospital
2020
Finnish Society of Sciences and Letters
2018
Tampere University
2015
Rajshahi Medical College
2009
Knowledge about features distinguishing deleterious and neutral variations is crucial for interpretation of novel variants. Bruton tyrosine kinase (BTK) contains the highest number unique disease-causing among human protein kinases, still it just 10% all possible single-nucleotide substitution-caused amino acid (SNAVs). In BTK domain (BTK-KD) can appear altogether 1,495 SNAVs. We investigated them with bioinformatic structure analysis methods. Most affect conserved buried residues disturbing...
β2-integrins are essential for immune system function because they mediate cell adhesion and signaling. Consequently, a loss of β2-integrin expression or causes the immunodeficiency disorders, Leukocyte Adhesion Deficiency (LAD) type I III. LAD-III is caused by mutations in an important integrin regulator, kindlin-3, but exactly how kindlin-3 regulates leukocyte has remained incompletely understood. Here we demonstrate that mutation binding site (TTT/AAA-β2-integrin knock-in mouse / KI)...
A prerequisite for lifelong sperm production is that spermatogonial stem cells (SSCs) balance self-renewal and differentiation, yet factors required this remain largely undefined. Using mouse genetics, we now demonstrate the ubiquitously expressed transcription factor upstream stimulatory (USF)1 critical maintenance of SSCs. We show USF1 not only detected in Sertoli as previously reported, but also Usf1-deficient mice display progressive spermatogenic decline a result age-dependent loss...
Dendritic cells (DC), the classic antigen-presenting of immune system, switch from an adhesive, phagocytic phenotype in tissues, to a mature, nonadhesive that enables migration lymph nodes activate T and initiate antitumor responses. Monocyte-derived DCs are used cancer immunotherapy, but their clinical efficacy is limited. Here, we show cultured bone marrow-derived (BM-DC) expressing dysfunctional β2-integrin adhesion receptors displayed enhanced tumor rejection capabilities B16.OVA B16-F10...
In meiosis, non-exchange homologous chromosomes are at risk for mis-segregation and should be monitored by the spindle assembly checkpoint (SAC) to avoid formation of aneuploid gametes. Sex chromosome is particularly common can lead sterility or offspring (e.g. individuals with Turner Klinefelter syndrome). Despite major implications health reproduction, modifiers meiotic SAC robustness subsequent apoptotic response in male mammals remain obscure. Levels proteins, e.g. MAD2, crucial normal...
Abstract Background MAPK/ERK signaling is a well-known mediator of extracellular stimuli controlling intracellular responses to growth factors and mechanical cues. The critical requirement for embryonic stem cell maintenance demonstrated, but specific functions in progenitor regulation during development, particular kidney development remain largely unexplored. We previously demonstrated as key regulator through branching morphogenesis normal nephrogenesis where it also regulates expansion....
A prospective study was conducted on 54 cases of neonatal intestinal obstruction, admitted in Paediatric surgery department Rajshahi Medical College Hospital during the period from January 2008 to December 2008, a 12 months. The objective find out etiological aspect and outcome patient with obstruction. constituted 33.7% total admission period. male: female ratio 1.4:1 age ranging 1 28 days. Birth weight most patients above 2 kg. Most came poor average family. Patients family are slightly...
SUMMARY Transition from smooth, lissencephalic brains to highly-folded, gyrencephalic structures is associated with neuronal expansion and breaks in neurogenic symmetry. Here we show that Neurog2 Ascl1 proneural genes regulate cortical progenitor cell differentiation through cross-repressive interactions sustain continuity a rodent brain. Using vivo lineage tracing, found expression defines continuum of four pools, ‘double + progenitors’ displaying several unique features (least...
Dendritic cells (DCs) are the main antigen presenting of immune system and essential for anti-tumor responses. DC-based immunotherapies used in cancer treatment, but their functionality is not optimized clinical efficacy currently limited. Approaches to improve DC immunity therefore required. We have previously shown that loss β2-integrin-mediated adhesion leads epigenetic reprogramming bone marrow-derived DCs (BM-DCs), resulting an increased expression costimulatory markers (CD86, CD80,...
<div>Abstract<p>Dendritic cells (DC), the classic antigen-presenting of immune system, switch from an adhesive, phagocytic phenotype in tissues, to a mature, nonadhesive that enables migration lymph nodes activate T and initiate antitumor responses. Monocyte-derived DCs are used cancer immunotherapy, but their clinical efficacy is limited. Here, we show cultured bone marrow–derived (BM-DC) expressing dysfunctional β2-integrin adhesion receptors displayed enhanced tumor rejection...
<div>Abstract<p>Dendritic cells (DC), the classic antigen-presenting of immune system, switch from an adhesive, phagocytic phenotype in tissues, to a mature, nonadhesive that enables migration lymph nodes activate T and initiate antitumor responses. Monocyte-derived DCs are used cancer immunotherapy, but their clinical efficacy is limited. Here, we show cultured bone marrow–derived (BM-DC) expressing dysfunctional β2-integrin adhesion receptors displayed enhanced tumor rejection...
<p>Supplementary Figure Legends</p>
<p>Supplementary Figures 1-10</p>
<p>Supplementary Figure Legends</p>
<p>Supplementary Figures 1-10</p>