A5014438129- Retinal Diseases and Treatments
- Cellular transport and secretion
- Retinal Development and Disorders
- Banana Cultivation and Research
- Erythrocyte Function and Pathophysiology
- Nematode management and characterization studies
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Entomopathogenic Microorganisms in Pest Control
University of California, Davis
2019-2022
Root-knot nematodes cause forking and stubbing of the growing carrot root tip, decreasing market value reducing yield by up to 45%. Since crop damage these depends on their initial population densities at planting, preplant detection potentially low nematode numbers is critical for predicting future loss. The aim this study was overcome some drawbacks labor- time-intensive process root-knot identification quantification developing field testing a real-time PCR (qPCR) assay. Primers were...
ABSTRACT Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop similar pattern photoreceptor degeneration. Arap1 an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynamics. Curiously, expression was detected in Müller glia and pigment epithelium (RPE), but not photoreceptors themselves. In this study, generated conditional knockout for glia/RPE, RPE via targeting...
ABSTRACT Purpose Arap1 is an Arf-directed GTPase-activating protein (GAP) shown to modulate actin cytoskeletal dynamics by regulating Arf and Rho family members. We have previously that -/- mice develop photoreceptor degeneration similar the human condition retinitis pigmentosa (RP), corroborated fundus examination, histopathology, ERG analysis. However, expression was not detected in photoreceptors, but Müller Glia retinal pigment epithelium (RPE), suggesting a non-cell-autonomous mechanism...