A5036531730- Retinal Diseases and Treatments
- Cellular transport and secretion
- Retinal Development and Disorders
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Sleep and related disorders
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Neonatal Respiratory Health Research
- Hemoglobin structure and function
Children's Hospital of The King's Daughters
2023
Eastern Virginia Medical School
2023
University of California, Davis
2017-2022
Howard Hughes Medical Institute
2018
Importance The utility of adenotonsillectomy in children who have habitual snoring without frequent obstructive breathing events (mild sleep-disordered [SDB]) is unknown. Objectives To evaluate early compared with watchful waiting and supportive care (watchful waiting) on neurodevelopmental, behavioral, health, polysomnographic outcomes mild SDB. Design, Setting, Participants Randomized clinical trial enrolling 459 aged 3 to 12.9 years an apnea-hypopnea index (AHI) less than enrolled at 7 US...
Purpose: Small guanosine triphosphatase (GTPase) ADP-ribosylation factors (Arfs) regulate membrane traffic and actin reorganization under the control of GTPase-activating proteins (GAPs). Arap1 is an Arf-directed GAP that inhibits trafficking epidermal growth factor receptor (EGFR) to early endosome, but diversity its functions incompletely understood. The aim this study was determine role in mammalian retina. Methods: Genetically engineered knockout mice were screened for ocular...
ABSTRACT Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop similar pattern photoreceptor degeneration. Arap1 an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynamics. Curiously, expression was detected in Müller glia and pigment epithelium (RPE), but not photoreceptors themselves. In this study, generated conditional knockout for glia/RPE, RPE via targeting...
Children with snoring and mild sleep-disordered breathing may be at increased risk for neurocognitive deficits despite few obstructive events. We hypothesized that actigraphy-based sleep duration continuity associate neurobehavioral functioning explored whether these associations vary by demographic socioeconomic factors.
SUMMARY Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death is triggered by chromosome synapsis and recombination, which involve repair of programmed DNA double-strand breaks (DSBs) between homologous chromosomes. We show that RNF212, a SUMO ligase required for crossing over, also mediates control. Both physiological apoptosis wholesale oocytes elimination meiotic mutants require RNF212. RNF212 sensitizes cells to DSB-induced within narrow window when...
ABSTRACT Purpose Arap1 is an Arf-directed GTPase-activating protein (GAP) shown to modulate actin cytoskeletal dynamics by regulating Arf and Rho family members. We have previously that -/- mice develop photoreceptor degeneration similar the human condition retinitis pigmentosa (RP), corroborated fundus examination, histopathology, ERG analysis. However, expression was not detected in photoreceptors, but Müller Glia retinal pigment epithelium (RPE), suggesting a non-cell-autonomous mechanism...