A5027383606- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Infectious Diseases and Tuberculosis
- Osteomyelitis and Bone Disorders Research
- Thermography and Photoacoustic Techniques
- Infrared Thermography in Medicine
- S100 Proteins and Annexins
- Infective Endocarditis Diagnosis and Management
- Knee injuries and reconstruction techniques
- Bacterial biofilms and quorum sensing
- Surgical site infection prevention
- thermodynamics and calorimetric analyses
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Hemostasis and retained surgical items
- Ultrasound and Hyperthermia Applications
- Medical and Biological Sciences
- Blood transfusion and management
- Bone health and osteoporosis research
- Antimicrobial Peptides and Activities
- Dyeing and Modifying Textile Fibers
- Antifungal resistance and susceptibility
- Orthopedic Surgery and Rehabilitation
Istituto Ortopedico Galeazzi
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2024
Istituto Clinico Sant'Ambrogio
2024
University of Milan
2018
Orthopedic Institute
2014
United Nations
2014
The treatment of chronic osteomyelitis often includes surgical debridement and filling the resultant void with antibiotic-loaded polymethylmethacrylate cement, bone grafts or substitutes. Recently, use bioactive glass to treat defects in infections has been reported a limited series patients. However, no direct comparison between this biomaterial substitute performed. In retrospective study, we compared safety efficacy local application S53P4 27 patients affected by long bones (Group A) two...
This study aimed to explore the in vitro antibacterial activity of bioglass BAG S53P4 against multi-resistant microorganisms commonly involved osteomyelitis and evaluate its use surgical adjunctive treatment osteomyelitis.
Infection is one of the main reasons for failure orthopedic implants. Antibacterial coatings may prevent bacterial adhesion and biofilm formation, according to various preclinical studies. The aim present study report first clinical trial on an antibiotic-loaded fast-resorbable hydrogel coating (Defensive Coating, DAC®) surgical site infection, in patients undergoing internal osteosynthesis closed fractures. In this multicenter randomized controlled prospective study, a total 256 five...
INTRODUCTION AND METHODS: Ten currently available classifications were tested for their ability to describe a continuous cohort of 300 adult patients affected by bone and joint infections. Each classification only focused, on the average, 1.3 ± 0.4 features single clinical condition (osteomyelitis, implant-related infections, or septic arthritis), being able classify 34.8 24.7% patients, while comprehensive system could all considered in study. RESULT CONCLUSION: A permits more accurate...
Outcome data on two-stage revision surgery for deep infection after septic hip arthritis are limited and inconsistent. This study presents the medium-term results of a new, standardized arthroplasty with preformed spacers cementless implants in consecutive series adult patients treated according to same protocol.Nineteen (20 hips) were enrolled this prospective, non-randomized cohort between 2000 2008. The first stage comprised femoral head resection, debridement, insertion preformed,...
The few available studies directly comparing aseptic and septic joint revision surgery report conflicting results. We investigated whether two-stage of hip prosthesis with a preformed antibiotic-loaded spacer an uncemented provides function quality life similar to those provided by in the medium term, as well associated direct hospital costs. prospectively evaluated (Harris score) (WOMAC SF-12 scores) 80 patients who underwent one-stage for loosening (Group A, 40 patients) or total...
Two-stage revision is the most widely accepted and performed intervention for chronically infected hip prostheses. In recent years short long stem antibiotic-loaded preformed spacers have become available on market. The aim of this prospective, comparative study was to assess safety efficacy versus spacers. From year 2000 2007 102 consecutive patients underwent two-stage septic replacement with a cement spacer cementless modular prosthesis. Patients were divided in two groups: Group L (long...
Isolated reports indicate the efficacy of infrared thermography for monitoring wound healing and septic complications, but no long-term analysis has ever been performed on this, there are data telethermographic patterns surgical site after uncomplicated total hip prosthesis knee prosthesis.In this prospective, observational, nonrandomized cohort study, two groups with forty consecutive patients each, who were operated respectively replacements, underwent examination contralateral joints...
Abstract. Background: Implant-related infections remain a major complication after orthopaedic surgery. Antibacterial coating of implants may prevent bacterial adhesion and biofilm formation. However, in spite extensive preclinical research the field, antibacterial coatings to protect clinical setting particularly few. The aim present study is evaluate safety calcium-based, antibiotic-loaded bone substitute as an cementless joint prosthesis.Methods: From March 2013 August 2015, 20...
Implant-related infections, including those of peri-prosthetic joint (PJIs), osteosynthesis and other biomaterials, are biofilm-related. Pathogen identification is considered the diagnostic benchmark; however, presence bacterial biofilms makes pathogen detection with traditional microbiological techniques only partially effective. To improve accuracy, some biofilm debonding have been recently proposed. Aim this health economics assessment study was to evaluate their economic impact on...
Antibiotic-loaded bone graft substitutes are attractive clinical options and have been used for years either prophylaxis or therapy periprosthetic fracture-related infections. Calcium sulfate hydroxyapatite can be combined in an injectable moldable substitute that provides dead space management with local release of high concentrations antibiotics a one-stage approach. With the aim to test preventive strategies against infections, commercial hydroxyapatite/calcium containing gentamicin...
Osteomyelitis (OM) is a major challenge in orthopedic surgery. The diagnosis of OM based on imaging and laboratory tests, but it still presents some limitations. Therefore, deeper comprehension the pathogenetic mechanisms could enhance diagnostic treatment approaches. pathogenesis an inflammatory response to pathogen infection, leading bone loss. present study aims investigate potential role panel osteoimmunological serum biomarkers clinical approach OM. focus emerging infection biomarker...
Periprosthetic hip infections with severe proximal femoral bone loss may require the use of limb salvage techniques, but no agreement exists in literature regarding most effective treatment. Aim this study is to analyze infection eradication rate and implant survival at medium-term follow-up patients treated megaprostheses for periprosthetic loss.Twenty-one consecutive were retrospectively reviewed a mean 64-month (24-120). Functional pain scores, microbiological, radiological intraoperative...
Abstract This retrospective study was undertaken to (i) define the most appropriate thresholds for serum d ‐dimer and fibrinogen differentiating aseptic failure from periprosthetic joint infection (PJI) (ii) evaluate predictive value of our threshold compared previously proposed thresholds. observational cohort included consecutive patients who had undergone total knee arthroplasty (TKA) revision between January 2019 December 2020. International Consensus Meeting diagnostic criteria were...