A5025170167- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Lysosomal Storage Disorders Research
- Erythrocyte Function and Pathophysiology
- Advanced Glycation End Products research
- Orthopedic Infections and Treatments
- Diabetes and associated disorders
- Glycosylation and Glycoproteins Research
- Lipid Membrane Structure and Behavior
- Orthopaedic implants and arthroplasty
- Sexual function and dysfunction studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal Health and Biochemistry
- Protein Hydrolysis and Bioactive Peptides
- Hormonal and reproductive studies
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Cellular transport and secretion
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Rheumatoid Arthritis Research and Therapies
University of Milan
2016-2025
Istituto Clinico Sant'Ambrogio
2025
IRCCS Istituto Auxologico Italiano
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Marche Polytechnic University
2011-2023
German Centre for Cardiovascular Research
2021
DRK Kliniken Berlin
2021
Ospedali Riuniti di Ancona
2002-2018
University of Bologna
2013-2018
Carlo Forlanini Hospital
2018
There is still no “gold standard” for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule presepsin, soluble fraction CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees severity. The aim this study was investigate prognostic value presepsin PJI. A total 30 patients with PJI without were enrolled. Presepsin, C-reactive protein (CRP), interleukin (IL)-6,...
Background/Objectives: The COVID-19 pandemic has increased interest in osteoimmunology because of the impact SARS-CoV-2 on both immune system and bone microenvironment. Soluble CD14ST could influence production osteoimmunological regulators osteoclast differentiation. aim this study is to evaluate role sCD14ST COVID-19’s effects remodeling—evaluating, particular, correlation with new-generation biomarkers—and acquire comprehensive knowledge disease skeletal system. Methods: serum level was...
Glyoxalase II has been docked with actin and malate dehydrogenase a direct involvement of the GlxII active site was found. The presence GSH in catalytic promotes protein–protein stabilization.
Glyoxalase II, the second of 2 enzymes in glyoxalase system, is a hydroxyacylglutathione hydrolase that catalyses hydrolysis S-d-lactoylglutathione to form d-lactic acid and glutathione, which released from active site. The tripeptide glutathione major sulfhydryl antioxidant has been shown control several functions, including S-glutathionylation proteins. S-Glutathionylation way for cells store reduced during oxidative stress, or protect protein thiol groups irreversible oxidation, few...
Skeletal muscle atrophy is a well-known adverse effect of chronic treatment with glucocorticoids and it also occurs when stress conditions such as sepsis cachexia increase the release endogenous glucocorticoids. Although mechanisms action these hormones have been elucidated, possible molecular causing are not yet fully understood. The involvement O-GlcNAcylation process has recently reported in disuse atrophy. O-GlcNAcylation, regulatory post-translational modification nuclear cytoplasmic...
Abstract Δ16HER2 is a splice variant of HER2 and defined as the transforming isoform in HER2-positive breast cancer. It has been shown that promotes cancer aggressiveness drug resistance. In present work, we used silico modeling to identify structural differences between wild-type proteins. We then developed DNA vaccines specifically against showed these immunotherapies hampered carcinogenesis transplantable model. However, failed elicit immune protection transgenic mice because tolerogenic...
Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) converted into l-arginine (l-Arg), the precursor from which nitric generated. The level of l-Arg and l-Cit in field male sexual function remains relatively underexplored. aim study was evaluate serum group patients with erectile dysfunction. Diagnosis severity dysfunction based on IIEF-5 its etiology classified as arteriogenic (A-ED), borderline (BL-ED), non-arteriogenic (NA-ED) echo-color-Doppler basal...
As a part of research project aimed to optimize antioxidant delivery, here we studied the influence both salts and lipid matrix composition on interaction epigallocatechin-3-gallate (EGCG) with bilayer leaflets. Thus, combined in silico experimental methods study ability neutral anionic vesicles encapsulate EGCG presence Ca2+ Mg2+ divalent salts. Experimental results show very high correlation, thus confirming efficiency developed methodology. In particular, found out that calcium ions...
The ketogenic diet (KD) is a high-fat, low-carbohydrate based on the induction of synthesis ketone bodies (KB). Despite its widespread use, systemic impact KD not completely understood. purpose this study was to evaluate effects physiological levels KB HMEC-1 endothelial cells. To aim, DNA oxidative damage and activation Nrf2, known transcriptional factor involved in cell responses stress, were assessed. exposure cells exerted moderate genotoxic effect, measured by significant increase...
We present a novel liposomal nanocarrier containing mannose 6-phosphate-cholesteryl conjugates and show its ability to reach the lysosomes by means of confocal fluorescence microscopy measurements.
Permethrin and its metabolites affect the structure activity of Cu/Zn superoxide dismutase (SOD), as it results from intrinsic fluorescence, 8-ANS fluorescence techniques and<italic>in silico</italic>studies.
Abstract Cathechins and flavonoids are responsible of numerous health benefits. Two the most representatives’ compounds for their antioxidant therapeutic effects Epigallocatechin 3‐Gallate (EGCG), from green tea extracts, morelloflavone (MF), Garcinia dulcis . Here we explore, by atomistic Molecular Dynamics simulations, how EGCG MF interact with lipid bilayers show salts’ influence on encapsulation degree in neutral liposomes. As a result, found out that EGCGs naturally bind to hydrophilic...
Osteomyelitis (OM) is a major challenge in orthopedic surgery. The diagnosis of OM based on imaging and laboratory tests, but it still presents some limitations. Therefore, deeper comprehension the pathogenetic mechanisms could enhance diagnostic treatment approaches. pathogenesis an inflammatory response to pathogen infection, leading bone loss. present study aims investigate potential role panel osteoimmunological serum biomarkers clinical approach OM. focus emerging infection biomarker...