A5010537056- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Diabetes and associated disorders
- Erythrocyte Function and Pathophysiology
- Glycosylation and Glycoproteins Research
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Calcium signaling and nucleotide metabolism
- Pancreatitis Pathology and Treatment
- Carbohydrate Chemistry and Synthesis
- Advanced Glycation End Products research
- Infant Nutrition and Health
- Diabetic Foot Ulcer Assessment and Management
- Diabetes Management and Research
- Glycogen Storage Diseases and Myoclonus
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Adenosine and Purinergic Signaling
- Trypanosoma species research and implications
- Orthopedic Infections and Treatments
- Exercise and Physiological Responses
- Biochemical effects in animals
- Biochemical and Molecular Research
- Biomedical Research and Pathophysiology
University of Milan
2006-2019
Ospedale Bassini
2000-2002
Chemi (Italy)
2002
Ospedali Riuniti di Ancona
2002
University of Padua
1999-2000
Skeletal muscle atrophy is a well-known adverse effect of chronic treatment with glucocorticoids and it also occurs when stress conditions such as sepsis cachexia increase the release endogenous glucocorticoids. Although mechanisms action these hormones have been elucidated, possible molecular causing are not yet fully understood. The involvement O-GlcNAcylation process has recently reported in disuse atrophy. O-GlcNAcylation, regulatory post-translational modification nuclear cytoplasmic...
Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) converted into l-arginine (l-Arg), the precursor from which nitric generated. The level of l-Arg and l-Cit in field male sexual function remains relatively underexplored. aim study was evaluate serum group patients with erectile dysfunction. Diagnosis severity dysfunction based on IIEF-5 its etiology classified as arteriogenic (A-ED), borderline (BL-ED), non-arteriogenic (NA-ED) echo-color-Doppler basal...
In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation response agonists. For this reason, OS is considered a key factor Alzheimer's Disease (AD) development recent evidence correlated oxidative stress lesion pathogenesis of AD, but mechanism still need be fully clarified. The etiology AD not completely understood...
Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED often multifactorial but evidence being accumulated in favor the proper function vascular endothelium that essential to achieving and maintaining penile erection. Uric acid itself causes via decreased nitric oxide production. This study aims evaluate serum uric (SUA) levels 180 patients, diagnosed with International Index Function-5 (IIEF-5) 30 non-ED control. Serum was analyzed...
Prosthetic joint infection (PJI) is the most common cause of failure total arthroplasty, but a gold standard for PJI diagnosis still lacking. Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAGE). The aim this study was evaluate plasmatic soluble receptor advanced (sRAGE), as new OS and marker correlating sRAGE level antioxidant defenses, in PJI, order explore possible...
The membrane anchoring of the following glycohydrolases human erythrocyte plasma membranes was investigated: α‐ and β‐ D ‐glucosidase, ‐galactosidase, ‐glucuronidase, N ‐acetyl‐β‐ ‐glucosaminidase, ‐mannosidase, L ‐fucosidase. Optimized fluorimetric methods for assay these enzymes were set up. Treatment ghost preparation with 1.0 mol/l (optimal concentration) NaCl caused release ranging from 4.2% ‐glucosidase to 70% ‐galactosidase; treatment 0.4% Triton X‐100 liberated 5.1% ‐galactosidase...
High Crosslink process was introduced in the development of joint prosthetic devices, order to decrease wear rate ultrahigh molecular weight polyethylene (UHMWPE) but it also triggers formation free radicals and oxidative stress, which affects physiological bone remodelling, leading osteolysis. Vitamin E stabilization UHMWPE proposed provide oxidation resistance without affecting mechanical properties fatigue strength. The aim this study is evaluate antioxidant effect vitamin added on stress...
Oxidative stress (OS) and production of NO, by endothelium nitric oxide synthetase (eNOS), are involved in the pathophysiology erectile dysfunction (ED). Moreover, OS induces modifications physicochemical properties erythrocyte (RBC) plasma membranes enzyme content same membranes. Due to their role signalling early membrane alterations OS-related pathologies, several cytosolic glycohydrolases human RBC have been proposed as new markers cellular OS. In RBC, NOS can be activated deactivated...