A5013998548- Sperm and Testicular Function
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Bee Products Chemical Analysis
- Pancreatic function and diabetes
- Reproductive Biology and Fertility
- Heat shock proteins research
- Chronic Lymphocytic Leukemia Research
- Insect and Pesticide Research
- Diabetes Management and Research
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Animal Genetics and Reproduction
- Animal Behavior and Welfare Studies
- Cancer-related Molecular Pathways
- Veterinary Medicine and Surgery
- Tea Polyphenols and Effects
- Nutrition and Health in Aging
- Cell death mechanisms and regulation
- Cancer therapeutics and mechanisms
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Diet and metabolism studies
- Silkworms and Sericulture Research
University of Bari Aldo Moro
2007-2025
University of the Witwatersrand
2016
Azienda Ospedaliera S.Giuseppe Moscati
2010-2015
Institute of Molecular and Translational Medicine
2012
Palacký University Olomouc
2012
Institute of Food Science
2012
University of Bologna
2004-2008
University of Milan
2004
University of Parma
1993
Washington University in St. Louis
1986
Controversy exists concerning the degree of importance periventricular intraparenchymal echodensities (IPE) observed on neonatal ultrasound scans in determination subsequent neurologic disability premature infants. In this report, IPE was studied 75 infants weighing less than 2,000 g at birth to determine basic characteristics lesion, likely pathogenesis, outcome, and aspects ultrasonographic appearance acute period illness that are important for prediction outcome. defined as any...
Nonalcoholic fatty liver disease (NAFLD) is commonly observed in patients with type 2 diabetes (T2D). Semaglutide, a glucagon-like peptide 1 receptor agonist, may have therapeutic role by targeting common mechanisms involved the pathophysiology of T2D and NAFLD. The study aimed to assess effectiveness Semaglutide on NAFLD T2D.Forty-eight were treated subcutaneous add-on metformin for 52 weeks. After baseline visit (T0), follow-up was scheduled quarterly (T3, T6) then at 12 months therapy...
Oral semaglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1RA) designed for oral administration; it offers a promising opportunity to facilitate an early approach Type 2 Diabetes (T2D). The study aimed evaluate, in real-life setting, effects of on body composition patients with T2D after 26 weeks therapy.Thirty-two were evaluated at baseline (T0) and three (T3) six (T6) months therapy semaglutide. At each time point, was assessed using phase sensitive bioimpedance analyzer....
Background: Body weight (BW) loss is an essential therapeutic goal in type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists are effective reducing BW, but their effect on body composition has not yet been fully explored. The study aim was to assess the impact of Semaglutide patients with T2D. Methods: Forty T2D were treated subcutaneous and evaluated at baseline (T0) after three (T3) six (T6) months. assessed by a phase-sensitive bioimpedance analyzer. Visceral adipose tissue...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely related to some metabolic disorders, such as central obesity and type 2 diabetes (T2D). Glucagon-like peptide 1 receptor agonists (GLP-1RAs), semaglutide, may have therapeutic roles in MASLD associated with T2D. This study aims investigate the molecular mechanisms underlying effectiveness of semaglutide on terms progression from steatosis fibrosis. We characterized exosomes ten patients (T2D) before (T0) after 12...
The presence and cellular distribution of heat protein 70 (Hsp70) in ejaculated, capacitated, acrosome-reacted boar spermatozoa was evaluated by immunofluorescence Western blot; the role Hsp70 during fertilization also studied. In freshly ejaculated spermatozoa, immunoreactivity is present a well-defined triangular-shaped area equatorial segment that seems to correspond sub-segment. fluorescent signal changes capacitated sperm, exhibit different patterns probably relation stage capacitation...
(1) Background: Glucagone-Like Peptide-1 Receptor Agonists (GLP-1 RAs) are incretine-based medications recommended in the treatment of type 2 Diabetes Mellitus (DM2) with atherosclerotic cardiovascular disease (ASCVD) or high very (CV) risk. However, knowledge direct mechanism GLP-1 RAs on cardiac function is modest and not yet fully elucidated. Left ventricular (LV) Global Longitudinal Strain (GLS) Speckle Tracking Echocardiography (STE) represents an innovative technique for evaluation...
Diabetic kidney disease (DKD) is one of the most life‐threatening complications diabetes and a leading cause chronic disease. Glucagon‐like peptide 1 receptor agonists (GLP1‐RAs) or sodium–glucose cotransporter 2 inhibitors (SGLT2is) appear to improve renal outcome in patients with Type (T2D). In this context, resistive index (RRI) useful doppler measure study DKD predict its evolution. The aim work was effect treatment GLP1‐RA SGLT2i on RRI relationship between glycometabolic parameters....
Heat shock proteins, besides their protective function against stresses, have been recently indicated as key factors for sperm fertilizing ability. Since sexing by high-speed flow-cytometry subjects them to different physical, mechanical, and chemical the present study was designed verify, immunofluorescence Western blot, whether sorting procedure induces any modification in amount cellular distribution of heat proteins 60, 70, 90 (Hsp60, Hsp70, Hsp90). Immunolocalization blot quantification...
Quercetin is a flavonoid naturally present in food and beverages belonging to the large class of phytochemicals with potential anti-cancer properties. Here, we investigated ability quercetin sensitise primary cells from chronic lymphocytic leukaemia (CLL) death receptor (DR) agonists, recombinant TNF-related-apoptosis-inducing ligand (rTRAIL) anti-CD95, fludarabine, widely used chemotherapeutic drug against CLL.Peripheral white blood were isolated patients incubated medium containing 50 ng...
Regulatory T cells (Tregs) are considered to be key immunomodulatory of the immune system and increased in chronic lymphocytic leukemia (CLL). Rai stage 0 identifies patients with early CLL for which there is no effective intervention at present time a “wait see” policy usually adopted. Some biological clinical studies have reported that green tea constituents, such as epigallocatechin-gallate (EGCG), antitumor effects on hematologic malignancies including CLL. We report data trial extracts...
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) induce body weight loss, but their effect on skeletal muscle mass (SMM) and strength needs to be better elucidated.
Heat shock proteins (Hsp)-60, -70 and -90 are important testis chaperones that fulfil several functions during sperm cell maturation. In post-meiotic cells, their expression may change or be undetectable in some species it evident mature spermatozoa. The aims of this study were to verify whether Hsp60, present the sperm, compare localization boar, stallion, cat dog spermatozoa by immunofluorescence. Hsp-60 immunoreactivity was detected midpiece all examined. stallion Hsp70 signal localized...
Contents Inner mitochondrial membrane potential (IMM) is considered a sensitive indicator for the energetic status and motility of spermatozoa. The relationship between sperm parameters evaluated by Computer Assisted Sperm Analyzer plasma integrity IMM assessed triple staining (PI/SYBR‐14 JC‐1) was in 10 dogs unknown fertility. showed large variations ranging from 10% to 98%. Proportion viable cells spermatozoa with high ranged 74% 99% 53% 87%, respectively. presence JC‐1 more strongly...
We evaluated the clinical impact, in daily practice, of sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) therapies patients with type 2 diabetes. Data from 500 unselected consecutive were retrospectively analyzed. Only those a full assessment at baseline (T0) after 3 (T3), 6 (T6), 12 (T12) months treatment SGLT2i or GLP1RA included study (n = 167). At baseline, had high mean body weight (BW), abdominal circumference (AC), mass index...
Orientation: A large body of research evidence indicates that both sex role identity (SRI) and psychological capital (PsyCap) may have critical implications for individual organisational well-being. As SRI is constituted sex-based personality traits it possible individuals’ PsyCap.Research purpose: The purpose this study was to investigate the relationship between positive construct PsyCap.Motivation study: Research on PsyCap has been explored independently one another with a lack exploring...
New antidiabetic drugs have simplified treatment regimens in patients with type-2 diabetes (T2D). More importantly, they proven to reduce cardiovascular risk by lowering insulin-resistance, blood pressure and body weight, addition avoiding inappropriate insulin therapy, responsible for hypoglycemic episodes weight gain. In this context, accurate assessment of the metabolic status T2D becomes essential. The C-peptide assay is a simple but often overlooked test that can provide fundamental...