A5083505189- Blood transfusion and management
- Erythrocyte Function and Pathophysiology
- Erythropoietin and Anemia Treatment
- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Pickering emulsions and particle stabilization
- Advanced Materials and Mechanics
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Micro and Nano Robotics
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
Inspire
2023
Harvard University
2021-2023
Center for Systems Biology
2021-2023
Dartmouth College
2016-2019
Erythropoietin enhances oxygen delivery and reduces hypoxia-induced cell death, but its pro-thrombotic activity is problematic for use of erythropoietin in treating hypoxia. We constructed a fusion protein that stimulates red blood production neuroprotection without triggering platelet production, marker thrombosis. The consists an anti-glycophorin A nanobody mutant (L108A). mutation activation receptor homodimers induce erythropoiesis thrombosis, maintains the tissue-protective signaling....
Abstract Human infants are born to breastfeed. While 50% of lactating persons struggle make enough milk, there no governmentally-approved drugs enhance lactation 1 . Here, we engineer a variant the naturally-occurring driver lactation, hormone Prolactin, increase its serum half-life and produce viable drug candidate. Our engineered variant, Prolactin-eXtra Long-acting (Prolactin-XL), is comprised endogenously active human prolactin fused an IgG Fc domain designed overcome unique development...
Abstract Erythropoietin enhances oxygen delivery and reduces hypoxia-induced cell death, but its pro-thrombotic activity is problematic for use of erythropoietin in treating hypoxia. We constructed a fusion protein that stimulates red blood production neuroprotection without triggering platelet production, marker thrombosis. The consists an anti-glycophorin A nanobody mutant (L108A). mutation activation receptor homodimers induce erythropoiesis thrombosis, maintains the tissue-protective...