A5001250550- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Genetics, Bioinformatics, and Biomedical Research
- RNA modifications and cancer
- SARS-CoV-2 detection and testing
- Chronic Lymphocytic Leukemia Research
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cardiovascular and exercise physiology
- Bladder and Urothelial Cancer Treatments
- Genomics and Rare Diseases
- SARS-CoV-2 and COVID-19 Research
- Cancer-related Molecular Pathways
- Muscle metabolism and nutrition
- Biosensors and Analytical Detection
- DNA Repair Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cervical Cancer and HPV Research
- HIV/AIDS drug development and treatment
Dartmouth–Hitchcock Medical Center
2016-2025
Dartmouth College
2016-2025
Dartmouth Cancer Center
2023-2025
Dartmouth Hospital
1997-2025
Dartmouth Health
2022-2025
Dartmouth Psychiatric Research Center
2023-2025
Dartmouth Institute for Health Policy and Clinical Practice
2022-2023
Cotton (United States)
2008-2020
Columbia University Irving Medical Center
2019
New York University
2019
The National Cancer Institute-Children's Oncology Group Pediatric MATCH trial aimed to facilitate evaluation of molecular-targeted therapies in biomarker-selected cohorts childhood and young adult patients with cancer by screening tumors for actionable alterations.
MicroRNAs (miRNAs) are RNA molecules that involved in the regulation of many cellular processes, including those related to human cancers. The aim this study was determine, as a proof principle, whether specific candidate miRNAs could be detected fine-needle aspirate (FNA) biopsies pancreatic ductal adenocarcinoma (PDAC) and accurately differentiate malignant from benign tissues.We used TaqMan(R) assays quantify miRNA levels FNA samples collected RNARetain (n = 16) compared results with...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has the poorest overall prognosis among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly improves survival rates, indicating importance of early detection. Because abnormal microRNA production is commonly detected cancer, we investigated noninvasive precursor pancreatic intraepithelial neoplasia (PanIN) lesions for as a potential biomarker PDAC. Methods: Pathologists identified and classified...
To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for epsilon3 allele.Participants were healthy, intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had epsilon3/epsilon3 27 genotype. Gray data analyzed using general linear model as implemented in Statistical Parametric Mapping package,...
The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is accounted for by the absence early diagnostic markers and effective treatments. MicroRNAs inhibit translation their target mRNAs. production microRNAs strongly altered in cancers, but causes these alterations are only partially known. DNA hypermethylation a major cause gene inactivation cancer. Our aims were to identify whose expression inactivated PDAC determine whether this hypermethylation-mediated repression an event during...
Completion of the Human Genome Project, in conjunction with dramatic reductions cost DNA sequencing and advances translational research, is gradually ushering genomic discoveries technologies into practice medicine. The rapid pace these opening up a gap between knowledge available about clinical relevance information ability clinicians to include such their medical practices. This educational threatens be rate limiting adoption genomics Solutions will require not only better understanding...
Somatic mutation analysis is standard of practice for solid tumors in order to identify therapeutic sensitizing and resistance mutations. Our laboratory routinely performed standalone PCR-based methods mutations several genes. Rapid discovery introduction new therapeutics has demanded additional genomic information adequate management the cancer patient. We evaluated a next generation sequencing assay, Ion Torrent AmpliSeq Cancer Hotspot Panelv2 (CHPv2), capable identifying multiple somatic...
Next-generation sequencing-based genomic testing is standard of care for tumor workflows. However, its application across different institutions continues to be challenging given the diversity needs and resource availability among globally. Moreover, use a variety panels, including those from few individual genes involving hundreds genes, results in relatively skewed distribution patients. It imperative obtain higher level standardization without having restricted specific kits or requiring...
"Replace Cysto" is a multisite randomized phase 2 trial including 240 participants with low-grade intermediate-risk non-muscle-invasive bladder cancer, in which will be 1:1:1 to one of two urine marker-based approaches alternating marker test (Xpert Bladder Cancer Monitor or EpiCheck) cystoscopy frequent scheduled cystoscopy. The primary objective determine whether urinary quality life after surveillance significantly improved the arms. outcome patient-reported domain score validated...
Dietary calcium intake and the renin angiotensin system (RAS) regulate blood pressure (BP) by modulating homeostasis. Despite similar BP regulatory effects, influence of dietary alone combined with RAS polymorphisms on response following acute aerobic exercise (i.e., postexercise hypotension) has not been studied. Thus, we examined effect selected hypotension. Subjects were men (n = 50, 43.8 ± 1.3 yr) high (145.3 1.5/85.9 1.1 mm Hg). They completed three experiments: non-exercise control two...
ABSTRACT To characterize intracellular gram-negative bacteria associated with epitheliocystis in farmed Atlantic salmon ( Salmo salar ), gills proliferative lesions were collected for histopathology, conventional transmission and immunoelectron microscopy, situ hybridization, DNA extraction during outbreaks Ireland Norway 1999 2000, respectively, compared by ultrastructure immunoreactivity to nonproliferative from archived 1995. Genomic was used amplify 16S ribosomal (rDNA) molecular...
Abstract Background. Although genetic profiling of tumors is a potentially powerful tool to predict drug sensitivity and resistance, its routine use has been limited because clinicians are often unfamiliar with interpretation incorporation the information into practice. We established Molecular Tumor Board (MTB) interpret individual patients’ tumor profiles provide treatment recommendations. Patients Methods. DNA from specimens was sequenced in Clinical Laboratory Improvement...
Some epithelial neoplasms of the appendix, including low-grade appendiceal mucinous neoplasm and adenocarcinoma, can result in pseudomyxoma peritonei (PMP). Little is known about mutational spectra these tumor types whether mutations may be clinical significance with respect to therapeutic selection. In this study, we identified somatic using Ion Torrent AmpliSeq Cancer Hotspot Panel v2.Specimens consisted 3 nonneoplastic retention cysts/mucocele, 15 (LAMNs), 8 low-grade/well-differentiated...
Purpose This study examined the association of post-treatment changes in cognitive performance, apolipoprotein E (APOE), and smoking breast cancer patients treated with adjuvant therapy. Participants Methods Breast chemotherapy (N = 55, age 51.9 ± 7.1, education 15.7 2.6) were evaluated a battery neuropsychological tests prior to at 1, 6, 18 months post-chemotherapy. Matched groups not exposed 68, 56.8 8.3, 14.8 2.2) healthy controls 43, 53.0 10.1, 15.2 similar intervals. APOE epsilon 4...
Abstract Purpose: To assess the clinical and pharmacodynamic activity of dovitinib in a treatment-resistant, molecularly enriched non–muscle-invasive urothelial carcinoma bladder (NMIUC) population. Experimental Design: A multi-site pilot phase II trial was conducted. Key eligibility criteria included following: Bacillus Calmette-Guerin (BCG)-unresponsive NMIUC (>2 prior intravesical regimens) with increased phosphorylated FGFR3 (pFGFR3) expression by centrally analyzed...
The tumor suppressor gene TP53 is the most frequently mutated in human cancer. It encodes p53, a DNA-binding transcription factor that regulates multiple genes involved DNA repair, metabolism, cell cycle arrest, apoptosis, and senescence. associated with cancer by mutations lead to loss of wild-type p53 function as well confer alternate oncogenic functions enable them promote invasion, metastasis, proliferation, survival. Identifying discrete cells may help direct therapies are more...