A5027707597- Prostate Cancer Treatment and Research
- Virus-based gene therapy research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Urological Disorders and Treatments
- Xenotransplantation and immune response
- Urologic and reproductive health conditions
- Renal and Vascular Pathologies
- Urinary Bladder and Prostate Research
- Fibroblast Growth Factor Research
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Pelvic floor disorders treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
Indiana University – Purdue University Indianapolis
2014-2024
Indiana University School of Medicine
2012-2024
Indiana University
2002-2024
University School
2020-2024
Indiana University Health
2002-2023
Richard L. Roudebush VA Medical Center
2013-2023
The London College
2022
National Oceanography Centre
2019-2020
British Oceanographic Data Centre
2020
Indianapolis Zoo
2012-2018
No AccessJournal of UrologyOncology1 Oct 2004TRANSITIONAL CELL CARCINOMA OF THE BLADDER FOLLOWING AUGMENTATION CYSTOPLASTY FOR NEUROPATHIC TREVOR M. SOERGEL, MARK P. CAIN, ROSALIA MISSERI, THOMAS A. GARDNER, MICHAEL O. KOCH, and RICHARD C. RINK SOERGELTREVOR SOERGEL , CAINMARK CAIN MISSERIROSALIA MISSERI GARDNERTHOMAS GARDNER KOCHMICHAEL KOCH RINKRICHARD View All Author Informationhttps://doi.org/10.1097/01.ju.0000140194.87974.56AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Abstract BACKGROUND Coactivator‐associated arginine methyltransferase 1 (CARM1) is a transcriptional coactivator of the androgen receptor (AR). It involved in regulation biologic functions AR. remains to be determined whether CARM1 prostatic carcinogenesis. METHODS The expression normal prostate epithelium, high‐grade intraepithelial neoplasia (PIN), and carcinoma tissue was examined 66 previously untreated patients with carcinomas, as well 12 hormone‐independent carcinoma, using...
Abstract Purpose: Antitumor activity of cancer immunotherapies may elicit immune responses to nontargeted (secondary) tumor antigens, or antigen spread. We evaluated humoral spread after treatment with sipuleucel-T, an immunotherapy for asymptomatic minimally symptomatic metastatic castration-resistant prostate (mCRPC), designed target prostatic acid phosphatase (PAP; primary antigen). Experimental Design: Serum samples from patients mCRPC enrolled in the placebo-controlled phase III IMPACT...
We evaluate the incidence and risk factors of parastomal hernia formation in patients undergoing radical cystectomy ileal conduit urinary diversion.We retrospectively reviewed Indiana University database between 2001 2011, identified 516 who underwent diversion. Overall 199 had a clinical followup at least 12 months all postoperative staging computerized tomography to confirm presence hernia. The is reported with correlations made demographic, patient level perioperative factors.A developed...
Abstract Purpose: The transcription factor nuclear factor-κB (NF-κB) promotes the production of angiogenic, antiapoptotic, and prometastatic factors that are involved in carcinogenesis. Experimental Design: Electromobility gel shift assays were used to evaluate NF-κB DNA binding vitro. functional relevance was assessed by both cDNA array analyses proliferation prostate cancer cells with without exposure an inhibitor, parthenolide. Immunohistochemistry staining for p65 subunit determine...
Osteocalcin (OC), a major noncollagenous bone matrix protein, is expressed prevalently in prostate cancer epithelial cells, adjacent fibromuscular stromal and osteoblasts locally recurrent metastasis [Matsubara, S., Wada, Y., Gardner, T.A., Egawa, M., Park, M.S., Hsieh, C.L., Zhau, H.E., Kao, C., Kamidono, Gillenwater, J.Y., Chung, L.W. (2001). Cancer Res. 61, 6012-6019]. We constructed an adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase...
Abstract Purpose: This phase II open-label study evaluated the effect of concurrent or sequential administration abiraterone acetate plus prednisone (AA + P) on sipuleucel-T manufacture and immune responses in metastatic castration-resistant prostate cancer (mCRPC) patients. Experimental Design: mCRPC patients received followed by AA P 1 day (concurrent) 10 weeks (sequential) after first infusion. treatment continued for 26 weeks. The primary endpoint was cumulative antigen presenting cell...
Abstract Purpose: To assess the clinical and pharmacodynamic activity of dovitinib in a treatment-resistant, molecularly enriched non–muscle-invasive urothelial carcinoma bladder (NMIUC) population. Experimental Design: A multi-site pilot phase II trial was conducted. Key eligibility criteria included following: Bacillus Calmette-Guerin (BCG)-unresponsive NMIUC (>2 prior intravesical regimens) with increased phosphorylated FGFR3 (pFGFR3) expression by centrally analyzed...
In the next decade pressures on ocean systems and communities that rely them will increase as multiple stressors of climate change, food security human activities start to impact. Our ability manage sustain our oceans depend data we collect information knowledge generated. Much uptake this be outside domain, for example by policy makers, local Governments, custodians other organizations, so it is imperative democratize or open access use data. This paper looks at how technologies, scoped...
The goal of this study is to develop a tissue-specific toxic gene therapy utilizing the prostate specific antigen (PSA) promoter for both androgen-dependent (AD) and androgen-independent (AI) PSA-secreting cancer cells. Ideally would be effective without necessity exposing target cells circulating androgens.An AI subline LNCaP, an AD human cell line, C4-2, was used in study. Castrated mice bearing C4-2 tumors secrete PSA. A transient expression experiment analyze activity two PSA promoters,...
We assessed the incidence of and analyzed factors that may help prevent major complications open conversion during laparoscopic nephrectomy at our institutions.We retrospectively all nephrectomies performed between August 1, 1999 July 31, 2001. Data were stratified for type, intraoperative postoperative complications. Conversion to surgery was emergency versus elective procedures.Of 292 procedures institutions in 2 years 213 (73%) involved nephrectomy, including 84 live donor nephrectomies,...
Clinical outcome is variable in prostate cancer patients treated with radical prostatectomy. The Gleason histologic grade of prostatic adenocarcinoma one the strongest predictors biologic aggressiveness cancer. We evaluated significance relative proportion high-grade (Gleason patterns 4 and/or 5) predicting progression prostatectomy.Radical prostatectomy specimens from 364 consecutive were totally embedded and whole mounted. Various clinical pathologic characteristics analyzed. All data,...
Mutations in the Wnt signalling cascade are believed to cause aberrant proliferation of colorectal cells through T-cell factor-4 (TCF4) and its downstream growth-modulating factors. HOXB13 is exclusively expressed prostate colorectum. In cancers, negatively regulates β-catenin/TCF4-mediated transactivation subsequently inhibits cell growth. To study role tumorigenesis, we evaluated expression 53 tumours originated from distal left colon rectum with their matching normal tissues using...
The expression of prostate-specific membrane antigen (PSMA) and (PSA), two well characterized marker proteins, remains highly active in the hormone refractory stage prostate cancer. In this study, an artificial chimeric enhancer (PSES) composed modified regulatory elements controlling PSA PSMA genes was tested for its promoter activity tissue specificity using reporter system. As a result, novel PSES remained silent PSA- PSMA-negative non-prostate cancer cell lines, but mediated high levels...
Sipuleucel-T is an autologous cellular immunotherapy used to treat asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Traditional short-term indicators of clinical response commonly with chemotherapy have not correlated survival in patients treated sipuleucel-T. This retrospective study aimed evaluate laboratory parameters as possible early biomarkers associated benefit following sipuleucel-T treatment. Patients from three randomized, controlled,...
To evaluate the utility of robotic repair injuries to ureter or bladder from obstetrical and gynaecological (OBGYN) surgeryA retrospective review all patients four different high-volume institutions between 2002 2013 that had a robot-assisted (RA) by urologist after an OBGYN genitourinary injury.Of 43 operations, 34 were hysterectomies: 10 open, RA, nine vaginally, five pure laparoscopic. Nine alternative operations: three caesarean sections, oophorectomies (one two laparoscopic), one RA...