A5101636896- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Cancer survivorship and care
- Urologic and reproductive health conditions
- Renal and related cancers
- Urological Disorders and Treatments
- CAR-T cell therapy research
- Patient-Provider Communication in Healthcare
- Monoclonal and Polyclonal Antibodies Research
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Urinary Bladder and Prostate Research
- Biosimilars and Bioanalytical Methods
- Pelvic floor disorders treatments
- Palliative Care and End-of-Life Issues
- Hormonal and reproductive studies
- Chronic Lymphocytic Leukemia Research
- Sexual function and dysfunction studies
- Systemic Sclerosis and Related Diseases
Murdoch Children's Research Institute
2024-2025
University of Southampton
2023-2025
Royal College of Nursing
2025
Arthur Smith Institute for Urology
2016-2023
Northwell Health
2016-2023
Feinstein Institute for Medical Research
2021-2023
Camden and Islington NHS Foundation Trust
2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020-2021
North Shore Diabetes and Endocrine Associates
2017-2019
Schrodinger (United States)
2019
Cancer Hits a Nerve Solid tumors sculpt their microenvironment to maximize growth and metastatic potential. This concept is illustrated most famously by tumor angiogenesis, process whereby induce the of new blood vessels boost supply oxygen blood-borne nutrients. Magnon et al. (p. 10.1126/science.1236361 ; see Perspective Isaacs ) now highlight important contribution made another microenvironmental component—developing autonomic nerve fibers—to metastasis. In mouse models prostate cancer,...
Accessible Summary What is Known on the Subject? Artificial intelligence (AI) freely available, responds to very basic text input (such as a question) and can now create wide range of outputs, communicating in many languages or art forms. AI platforms like OpenAI's ChatGPT passages that could be used plans care for people with mental health needs. As such, output difficult distinguish from human‐output, there risk its use go unnoticed. this Paper Adds Existing Knowledge? Whilst it known...
Under-diagnosis of anxiety and depression in Chronic Obstructive Pulmonary Disease (COPD) patients may have a negative impact on patient quality life result disparity between prevalence the recognition treatment these symptoms.To reveal associations with demographic, health-related clinical characteristics COPD seen UK primary care.Cross-sectional population-based postal survey comprising EQ-5D visual analogue scale (EQ-5D(VAS)), symptom control questionnaire, Hospital Anxiety Depression...
The number and diversity of cancer therapeutics in the pipeline has increased over past decade due to an enhanced understanding biology identification novel therapeutic targets. At same time, cost bringing new drugs market regulatory burdens associated with clinical drug development have progressively increased. finite eligible patients limited financial resources available evaluate promising represent rate-limiting factors effort translate preclinical discoveries into next generation...
Sipuleucel-T, an autologous cellular immunotherapy, was investigated in a randomized, double-blind, controlled trial to determine its biologic activity androgen-dependent prostate cancer (ADPC).Patients with detectable by serum prostate-specific antigen (PSA) following radical prostatectomy received 3 4 months of androgen suppression therapy, and were then randomized (2:1) receive sipuleucel-T (n = 117) or control 59). The primary endpoint time biochemical failure (BF) defined as PSA ≥ 3.0...
Abstract Purpose: Antitumor activity of cancer immunotherapies may elicit immune responses to nontargeted (secondary) tumor antigens, or antigen spread. We evaluated humoral spread after treatment with sipuleucel-T, an immunotherapy for asymptomatic minimally symptomatic metastatic castration-resistant prostate (mCRPC), designed target prostatic acid phosphatase (PAP; primary antigen). Experimental Design: Serum samples from patients mCRPC enrolled in the placebo-controlled phase III IMPACT...
No AccessJournal of UrologyAdult Urology1 Jan 2014Muscle Invasive Bladder Cancer: Examining Survivor Burden and Unmet Needs Nihal E. Mohamed, Phapichaya Chaoprang Herrera, Shawna Hudson, Tracey A. Revenson, Cheryl T. Lee, Diane Z. Quale, Christina Zarcadoolas, Simon J. Hall, Michael Diefenbach MohamedNihal Mohamed Department Urology Oncological Science, Icahn School Medicine at Mount Sinai, New York, York , HerreraPhapichaya Herrera HudsonShawna Hudson Family Community Health, Rutgers Robert...
People with colorectal cancer have impaired quality of life (QoL). We investigated what factors were most highly associated it. Four hundred and ninety-six people completed questionnaires about QoL, functioning, symptoms, co-morbidity, cognitions personal social factors. Disease, treatment co-morbidity data abstracted from case notes. Multiple linear regression identified modifiable unmodifiable independently predictive global (EORTC-QLQ-C30). Of factors, female sex (P<0.001), more...
We studied recurrence-free survival after partial vs radical nephrectomy for clinical stage T1 renal cell carcinoma in all patients and those up staged to pathological T3a.We retrospectively reviewed the records of 1,250 who underwent or clinically localized between 2006 2014. Recurrence-free was estimated using Kaplan-Meier method evaluated as a function type with log rank test Cox models, adjusting clinical, radiological characteristics.A total 86 recurrences (7%) were observed during...
Abstract The genetic transfer of antigen receptors is a powerful approach to rapidly generate tumor-specific T lymphocytes. Unlike the physiologic T-cell receptor, chimeric (CARs) encompass immunoglobulin variable regions or receptor ligands as their recognition moiety, thus permitting cells recognize tumor antigens in absence human leukocyte expression. CARs encompassing CD3ζ chain activating domain induce proliferation vitro, but limited survival. requirements for genetically targeted...
In a world confronted with new and connected challenges, novel strategies are needed to help children adults achieve their full potential, predict, prevent treat disease, equity in services outcomes. Australia's Generation Victoria (GenV) cohorts designed for multi-pronged discovery (what could improve outcomes?) intervention research actually works, how much whom?). Here, we describe the key features of its protocol.
OBJECTIVE To assess the outcomes for patients with Gleason score 8–10 prostate cancer treated brachytherapy, external beam radiotherapy (EBRT) and hormonal therapy (HT). PATIENTS AND METHODS In all, 181 scores were from 1994 to 2006 a 103 Pd implant (prescription dose 100 Gy), 45 Gy of EBRT 9 months HT. The median (range) follow‐up was 65 (24–150) months; freedom biochemical failure (FBF) rates calculated using Phoenix definition. RESULTS 8‐year actuarial FBF, distant metastases,...
Background: Prostate cancer is the most common affecting men in United States. Management options for localized disease exist, yet an evidence-based criterion standard treatment still has to emerge. Although 5-year survival rates approach 98%, all carry possibility significant side effects, such as erectile dysfunction and urinary incontinence. It therefore recommended that patients be actively involved decision process. We have developed Internet/CD-ROM-based multimedia Interactive...
Treatment options for metastatic castration resistant prostate cancer (mCRPC) have expanded rapidly in recent years. Given the significant economic burden, we sought perform a cost-effectiveness analysis (CEA) of contemporary treatment paradigm mCRPC. We devised protocol consisting sipuleucel-T, enzalutamide, abiraterone, docetaxel, radium-223, and cabazitaxel. estimated number length treatments each therapy using dosing schedules or progression free survival data from published clinical...
No AccessJournal of UrologyClinical Urology: Original Article1 Feb 1995Extensive Corporeal Fibrosis After Penile Irradiation Simon J. Hall, Guido Basile, Eduardo B. Bertero, Antonio de las Morenas, and Irwin. Goldstein HallSimon Hall , BasileGuido Basile BerteroEduardo Bertero MorenasAntonio Morenas GoldsteinIrwin. View All Author Informationhttps://doi.org/10.1097/00005392-199502000-00023AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
We describe the safety of sipuleucel-T using an integrated analysis 4 randomized, controlled studies in patients with prostate cancer.Adverse events, survival data and laboratory evaluations were examined for common, rare latent events.In 5% or more cases some adverse events reported at a rate least twice that controls, including chills 53.1%, pyrexia 31.3%, headache 18.1%, myalgia 11.8%, influenza-like illness 9.7% hyperhidrosis 5.0%. These generally occurred within 1 day infusion, grade 2...