A5100639681- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- Genetic Mapping and Diversity in Plants and Animals
- Gene expression and cancer classification
- Genetics and Neurodevelopmental Disorders
- Genetic diversity and population structure
- Genomics and Rare Diseases
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- Ethnobotanical and Medicinal Plants Studies
- Growth Hormone and Insulin-like Growth Factors
- Cancer Genomics and Diagnostics
- Autism Spectrum Disorder Research
- Entrepreneurship Studies and Influences
- RNA Research and Splicing
- Plant Gene Expression Analysis
- Traditional Chinese Medicine Studies
- Plant Molecular Biology Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Southwest University
2021
Yangzhou University
2004-2021
Zhejiang University
2020
Xinjiang Medical University
2019
Xijing Hospital
2013-2015
Air Force Medical University
2013-2015
Xi'an Jiaotong University
2012-2015
University of North Carolina at Chapel Hill
2014
Long noncoding RNAs (lncRNAs) have been shown to play critical roles in the development and progression of diseases. lncRNA activated by transforming growth factor beta (TGF-β) (lncRNA-ATB) was discovered as a prognostic hepatocellular carcinoma, gastric cancer, colorectal cancer. However, little is known about role lncRNA-ATB pancreatic This study aimed assess expression cancer explore its pathogenesis. Quantitative real-time polymerase chain reaction performed detect 150 tissues five cell...
A comprehensive understanding of the molecular differences between X and Y sperm in Holstein bull semen is crucial for advancing sex control technologies. While previous studies have primarily focused on proteomic transcriptomic differences, genome-wide DNA methylation these types remains largely unexplored. In this study, we employed whole-genome bisulfite sequencing to systematically compare autosomal profiles sperm. Although global patterns showed remarkable consistency two types, our...
Abstract Petal size determines the value of ornamental plants, and thus their economic value. However, molecular mechanisms controlling petal remain unclear in most non-model species. To identify quantitative trait loci candidate genes rapeseed (Brassica napus), we performed a genome-wide association study (GWAS) using data from 588 accessions over three consecutive years. We detected 16 significant single nucleotide polymorphisms (SNPs) associated with size, significant SNPs located on...
Abundant evidence indicates that long noncoding RNAs (lncRNAs) and circular (circRNAs) serve important roles in tumorigenesis tumour progression. However, their diagnostic treatment value for esophageal squamous carcinoma (ESCC) remains unknown. A microarray (SBC human ceRNA array V1.0) was performed to assess the expression profiles biological functions of lncRNAs, circRNAs mRNAs ESCC para-cancerous tissues from three patients. Microarray data were validated by reverse...
In Pakistan, traditional medicines are an important component of the medical system, with numerous varieties and great demands. However, due to scattered resources lack systematic collection collation, adulteration Pakistani medicine (TPM) is common, which severely affects safety their medicinal use import export trades. Therefore, it urgent systematically organize unify management TPM establish a set standards operable methods for identification TPM. We collected organized information on...
The 7 sheep microsatellite markersOarFCB48, OarAE101, MAF33, OarFCB11, MAF70, OarFCB304 and OarFCB128, which were located on chromosomes 2, 4, 6, 9, 17 19, selected to PCR in Hu sheep, Tong their closely related species,the goat.They studied with the amplifying result of sites Sheep, Sheep goats, data allele number range allele's size analyzed ANOVA.The results showed that there no significant differences (p<0.05) DNA among 3 populations.Concerning conservation microsatellites species,...
Increasing evidence has suggested that non-coding RNAs (ncRNAs) play critical roles in the pathogenesis of diabetic retinopathy (DR), but their underlying mechanisms remain unclear. The purpose this study was to determine latent key genes and structure a competing endogenous RNA (ceRNA) regulatory network discover potential molecular governing effects high glucose on human retinal endothelial cells (HRECs). We obtained microarray data for long (lncRNA) mRNA high-glucose-induced HREC samples...
The differences in small noncoding RNAs (sncRNAs), including miRNAs, piRNAs, and tRNA-derived fragments (tsRNAs), between X Y sperm of mammals remain unclear. Here, we employed high-throughput sequencing to systematically compare the sncRNA profiles from bulls (n = 3), which may have a wider implication for whole mammalian class. For comparison miRNA profiles, found that abundance bta-miR-652 bta-miR-378 were significantly higher sperm, while nine bta-miR-204 bta-miR-3432a, had greater (p <...
Objective To investigate the expression of Notch1 in hepatocellular carcinoma (HCC) tissues and to evaluate its relationship with clinicopathological features prognosis HCC patients.Methods A total 110 samples non-cancerous adjacent liver were collected from Xijing Hospital Fourth Military Medical University June 2005 2008.The expressions between patients analyzed using chi-square test Fisher exact probability.The survival curve was drawn by Kaplan-Meier method,and log-rank test.Results...
Using the method of "random sampling in typical colonies central area habitat", 60 Small-tailed Han sheep were obtained Jining city, Shangdong province.The variations at 12 structural loci encoding blood proteins detected by several electrophoresis techniques and their gene frequencies then estimated.The same data four other populations from Near-sea Mainland East Asia cited for analysis genetic differentiation.The average heterozygosities five populations, namely Kharkhorin sheep,...
Abstract Background: In sheep, FecB is the essential biomarker of fertility, previous researches have provided a detailed insight on regulation involved estrus phase and in reproductive-related tissues including hypothalamus, pituitary, ovary. However, as host embryo development connection between ovary uterus, little known about interaction mRNAs lncRNAs sheep oviduct. present study, RNA-Seq was performed to identify transcriptomic profiles oviduct during with BB/++ genotypes. Results:...
Transcriptome-wide association studies based on genetically predicted gene expression have the potential to identify novel regions associated with various complex traits. It has been shown that incorporating quantitative trait loci (eQTLs) corresponding multiple tissue types can improve power for involving etiology. In this article, we propose a new multivariate response linear regression model and method predicting in tissues simultaneously. Unlike existing methods multi-tissue joint eQTL...