A5021567929- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Caveolin-1 and cellular processes
- Diabetes Treatment and Management
- RNA modifications and cancer
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Research Data Management Practices
- Phagocytosis and Immune Regulation
Istituto Ortopedico Rizzoli
2020-2023
University of Bologna
2020-2022
Ewing sarcoma (EWS) is the second most common bone and soft tissue-associated malignancy in children young adults. It driven by fusion oncogene EWS/FLI1 characterized rapid growth early metastasis. We have previously discovered that mRNA binding protein IGF2BP3 constitutes an important biomarker for EWS as high expression of primary tumors predicts poor prognosis patients. additionally demonstrated enhances anchorage-independent migration cells suggesting might work molecular driver...
Ewing sarcoma (EWS) is the second most common pediatric bone tumor. The EWS tumor microenvironment largely recognized as immune-cold, with macrophages being abundant immune cells and their presence associated worse patient prognosis. Expression of CD99 a hallmark cells, its targeting induces inhibition growth through poorly understood mechanism. In this study, we analyzed expression functions on investigated whether concomitant both could explain inhibitory effect approach against EWS....
Abstract Ewing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with poor prognosis and an elevated tendency of metastases, as possible soluble mediator inter-cellular communication in EWS. Our data demonstrate that (i) IGF2BP3 detected cell supernatants, it released inside extracellular vesicles (EVs); (ii) EVs from IGF2BP3-positive or IGF2BP3-negative EWS cells...
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<div>Abstract<p>Ewing sarcoma (EWS) is the second most common pediatric bone tumor. The EWS tumor microenvironment largely recognized as immune-cold, with macrophages being abundant immune cells and their presence associated worse patient prognosis. Expression of CD99 a hallmark cells, its targeting induces inhibition growth through poorly understood mechanism. In this study, we analyzed expression functions on investigated whether concomitant both could explain inhibitory effect...
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