A5006127961- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Adrenal and Paraganglionic Tumors
- Metabolism and Genetic Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mitochondrial Function and Pathology
- Thyroid Disorders and Treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Stress Responses and Cortisol
- Pharmacology and Obesity Treatment
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Spaceflight effects on biology
- Thyroid Cancer Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- Regulation of Appetite and Obesity
- Cardiac pacing and defibrillation studies
- Diabetes Treatment and Management
Candiolo Cancer Institute
2020-2025
University of Turin
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
University of Chicago
2022-2024
University of Catania
2023
Institute of Cardiology
2013
University College London
2012
University of Genoa
1982-2008
Martin University
2000
Ipsen (France)
1997
The objective of the study was to determine tolerability and effectiveness slow release (SR) somatostatin analog lanreotide in active acromegaly. Fifty-seven patients, unselected terms their previous responsiveness octreotide therapy, were included a prospective, open label carried out at 6 Italian endocrinological centers. effects months SR lanreotide, given first every 14 days dosage 30 mg, im, recorded. In some patients (33%), drug adjusted by increasing dose (to 60 im) and/or shortening...
Acute myeloid leukemia (AML) is a complex hematologic malignancy with high morbidity and mortality. Nucleophosmin 1 (NPM1) mutations occur in approximately 30% of AML cases, NPM1-mutated classified as distinct entity. patients without additional genetic abnormalities have favorable prognosis. Despite this, 30-50% them experience relapse. This study aimed to investigate the potential total RNAseq improving characterization patients. We explored variations independently stratification,...
Serum concentrations of immunoreactive so-matomedin C, GH, and PRL were determined on samples obtained from 16 adult subjects throughout the day. Samples collected by a portable continuous flow, blood withdrawal pump. Somatomedin C stable during waking hours [1.13 ± 0.09 U/ml (mean SE)] but fell after onset sleep o t minimum value 0.85 0.08 U/ml. After awakening, concentration rose progressively to mean 1.26 0.10 between 1100–1200 h. These changes statistically significant. There no sex...
The aim of this study was to assess the incidence and clinical predictors development new-onset heart failure (HF) over medium-term follow-up, in patients treated with permanent pacing daily practice.We retrospectively enrolled all consecutive who underwent single- or dual-chamber pacemaker implantation at centre. Patients a left ventricular ejection fraction (LVEF) ≤35% prior diagnosis HF were excluded. Ventricular leads routinely implanted right apex. Pacemakers 490 standard indication...
Receptor tyrosine kinases (RTKs) inhibitors' activity in advanced osteosarcoma is significant but short-lived. To prevent or at least delay drug resistance, we explored a vertical inhibition by combining drugs acting different levels of the RTK pathways (pazopanib + trametinib). We studied pazopanib trametinib antitumor both vitro and vivo (MNNG-HOS KHOS xenografts NOD/SCID mice) investigating molecular mechanisms potential escapes. The involvement MAPK-PI3K was validated Nanostring...
Bone sarcomas are a group of heterogeneous malignant mesenchymal tumors. Complete surgical resection is still the cornerstone treatment, but, in advanced/unresectable setting, their management remains challenging and not significantly improved by target- immuno-therapies. We focused on tyrosine kinase Eph type-A receptor-2 (EphA2), key oncoprotein implicated self-renewal, angiogenesis, metastasis, several solid tumors thus representing novel potential therapeutic target. Aiming at better...
The aim of our study was to define the dose-response effect a short-term treatment with different recombinant human growth hormone (rhGH) doses (1.25, 2.5, 5.0, 10.0, and 20.0 μg ⋅ kg −1 day for 4 days) on insulin-like factor I (IGF-I) factor-binding protein (IGFBP)-3 levels in 21 normal young adults both sexes. dose 1.25 μg/kg rhGH did not modify IGF-I levels. 2.5 significantly increased men ( P < 0.05) but women, whereas higher sexes 0.002). IGFBP-3 were modified by or either sex. On...
BACKGROUND AND PURPOSE Parkinson's disease (PD) is characterized by progressive dopaminergic cell loss; however, the noradrenergic system exhibits degeneration as well. Noradrenergic deficit in PD may be responsible for certain non-motor symptoms of pathology, including psychiatric disorders and cognitive decline. The aim this study was to generate a pre-motor rodent model with denervation, assess whether treatment exendin-4 (EX-4), glucagon-like peptide 1 receptor agonist, could reverse...
To investigate the value of early phase MR enhancement breast lesions.To study 63 lesions (size 5-45 mm in diameter) 56 patients, whole-breast and lesion-targeted precontrast T1 -weighted gradient-echo 2D sequences were acquired. After intravenous injection Gd-DTPA (0.1 mmol/Kg), four targeted scans, each every 15 seconds during first minute (1-m), seven up to 8 minutes (8-m), performed. The subtraction technique was used, percent curves obtained. final diagnosis obtained by histology for 36...
Advanced and unresectable bone soft tissue sarcomas (BSTS) still represent an unmet medical need. We demonstrated that the alkylating agent trabectedin PARP1-inhibitor olaparib display antitumor activity in BSTS preclinical models. Moreover, a phase Ib clinical trial (NCT02398058), feasibility, tolerability encouraging results have been observed treatment combination is currently under study II (NCT03838744).Differential expression of genes involved DNA Damage Response Repair was evaluated...
Abstract Ewing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with poor prognosis and an elevated tendency of metastases, as possible soluble mediator inter-cellular communication in EWS. Our data demonstrate that (i) IGF2BP3 detected cell supernatants, it released inside extracellular vesicles (EVs); (ii) EVs from IGF2BP3-positive or IGF2BP3-negative EWS cells...
Abstract. The uraemic syndrome is characterized by several endocrinological disturbances. This study was undertaken in order to evaluate the GH response growth hormone-releasing hormone (GRH) children with chronic renal failure (CRF) and compare results those observed after insulin hypoglycaemia. Twenty-two CRF, 10 undergoing continuous ambulatory peritoneal dialysis (CAPD) 12 on conservative treatment (CT), age ranges 2–15 years, were studied data compared from 14 normal function hormonal...
To evaluate the role of endogenous opioid peptides in prolactin (Prl), growth hormone (GH) and cortisol neuroregulation, 50 mg opiate antagonist naloxone was infused over 24 h to 6 normal male volunteers. An additional dose (5 mg) given iv as a bolus injection at 20.00 h. blood specimens were collected hourly by means portable constant withdrawal pump. Naloxone failed alter secretion GH Prl. The sleep-related Prl rise also unaffected blocker. Moreover, circadian rhythm its concentration....
Acromegalic patients have an increased risk for the development of colorectal cancer. For this reason, since 1996, screening colonoscopy has been recommended in all with acromegaly. The aim our study was to assess feasibility and evaluate results computed tomography (CT)-colonography acromegaly.We examined 23 acromegalic no history cancer (11 females 12 males; age range 18-79 yr; disease duration 1-15 yr) CT-colonography. Twenty them underwent traditional after...
Introduction With the increasing incidence and prevalence of neurological disorders globally, there is a paramount need for new pharmacotherapies. BBB effectively protects brain but raises profound challenge to drug permeation, with less than 2% most drugs reaching CNS.
GH secretion was evaluated in 214 children and adolescents (age, 5-16 yr; 160 males 54 females) with short stature (height, < or = 5th percentile) by assessing mean spontaneous overnight concentration (normal values, > 3 3.9 micrograms/L for prepubertal pubertal subjects, respectively) responsiveness to stimulation GH-releasing hormone combined pyridostigmine peak 20 micrograms/L). Plasma insulin-like growth factor-I (IGF-I) also measured. According their secretory status, were grouped as...
Leiomyosarcomas are rare and aggressive tumors characterized by a complex karyotype. Surgical resection with or without radiotherapy chemotherapy is the standard curative treatment. Unfortunately, high percentage of leiomyosarcomas recurs metastasizes. In these cases, doxorubicin ifosfamide represent treatment but low response rates. Here, we evaluated induction proteotoxic stress as possible strategy to kill leiomyosarcoma cells in therapeutic perspective. We show that coexist levels...
Measurement of integrated concentration GH by means continuous withdrawal sampling is a method evaluating physiological hormonal secretion. Integrated was evaluated in 5 subjects with idiopathic hypogonadal hypogonadism (range 19-27 years) and 17-year-old male delay puberty (5 males, 1 female) before 30-240 days after the start pulsatile GnRH administration. Gonadotropins testosterone or 17 beta-estradiol were restored, whereas 24-h (before therapy 5.4 +/- 1.3 IU/1; during 8.1 2.0 P less...