A5077264591- Genetics, Aging, and Longevity in Model Organisms
- Parkinson's Disease Mechanisms and Treatments
- Circadian rhythm and melatonin
- Nuclear Receptors and Signaling
- Neuroendocrine regulation and behavior
- Genetic and Kidney Cyst Diseases
- Neurological diseases and metabolism
- Nerve injury and regeneration
- Microtubule and mitosis dynamics
- Neurological disorders and treatments
- Renal function and acid-base balance
- Cytomegalovirus and herpesvirus research
- Nuclear Structure and Function
- Botulinum Toxin and Related Neurological Disorders
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Prion Diseases and Protein Misfolding
- Olfactory and Sensory Function Studies
- Alzheimer's disease research and treatments
- Neurobiology and Insect Physiology Research
- Eating Disorders and Behaviors
- Biomedical Research and Pathophysiology
- Obsessive-Compulsive Spectrum Disorders
- Protist diversity and phylogeny
- Genetic Syndromes and Imprinting
University of Rochester
2005-2024
University of Rochester Medical Center
2014
Institute of Developmental Physiology
2010
Columbia University
2001
The effect of the detailed connectivity a neural circuit on its function and resulting behavior organism is key question in many systems. Here, we study for nociception C. elegans, which composed same neurons two sexes that are wired differently. We show nociceptive sensory respond similarly sexes, yet animals display sexually dimorphic behaviors to aversive stimuli. To uncover role downstream network topology shaping behavior, learn simulate models replicate observed use them predict simple...
Parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons substantia nigra (SN). Although 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model oxidative SN injury is frequently used to study degeneration mice and non-human primates, an understanding temporal sequence molecular events from inhibition mitochondrial complex 1 neuronal cell death limited. Here, microarray analysis integrative data mining were uncover pathways...
Abstract Primary cilia have essential roles in transducing signals eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides substrate for intraflagellar transport. However, extent to which axonemal microtubules are specialized sensory function unknown. In nematode Caenorhabditis elegans, primary present at dendritic ends of most neurons, where they provide environment transduction particular stimuli. Here, we find three...
Sexual maturation must occur on a controlled developmental schedule. In mammals, Makorin3 (MKRN3) and the miRNA regulators LIN28A/B are key of this process, but how they act is unclear. C. elegans, sexual nervous system includes functional remodeling postmitotic neurons onset adult-specific behaviors. Here, we find that lin-28–let-7 axis (the ‘heterochronic pathway’) determines timing these events. Upstream lin-28, Makorin lep-2 lncRNA lep-5 regulate cell-autonomously, indicating distributed...
For sexually reproducing animals, selecting optimal mates is important for maximizing reproductive fitness. In the nematode C. elegans, populations reproduce largely by hermaphrodite self-fertilization, but cross-fertilization of hermaphrodites males also occurs. Males' ability to recognize involves several sensory cues, an integrated view ways use these cues in their native context assess characteristics potential has been elusive. Here, we examine mate-preference behavior elegans evoked...
Background In most animal species, males and females exhibit differences in behavior morphology that relate to their respective roles reproduction. DM (Doublesex/MAB-3) domain transcription factors are phylogenetically conserved regulators of sexual development. They thought establish traits by sex-specifically modifying the activity general developmental programs. However, there few examples where details these interactions known, particularly nervous system. Methodology/Principal Findings...
Autosomal dominant polycystic kidney disease (ADPKD) results from loss-of-function mutations in PKD1 or PKD2. The products of these genes, the polycystins PC-1 and PC-2, form a transmembrane channel that is necessary for flow sensing by renal cilia. In C. elegans, polycystin orthologs LOV-1 PKD-2 function sensory neurons mediate male mating behavior. Here, we report novel single-pass membrane protein CWP-5 signaling during response step As with polycystins, localizes to neuronal cilia; this...
Each sensory ray of the Caenorhabditis elegans male tail comprises three distinct neuroglial cell types. These cells descend from a single progenitor, precursor cell, through several rounds asymmetric division called sublineage. Ray development requires conserved atonal-family bHLH gene lin-32, which specifies neuroblast and promotes differentiation its progeny. However, mechanisms that allocate specific fates among these progeny are unknown. Here we show distribution LIN-32 during...
SUMMARY How sexually dimorphic behavior is encoded in the nervous system poorly understood. Here, we characterize nociceptive C. elegans and study underlying circuits, which are composed of same neurons but wired differently. We show that while sensory transduction similar two sexes, downstream network topology markedly shapes behavior. fit a model replicates observed response to external stimuli, use it predict simple rewirings would switch between sexes. then experimentally these subtle...
SUMMARY Dynamic integration of internal and external cues is essential for flexible, adaptive animal behavior. In C. elegans , biological sex feeding state regulate expression the food-associated chemoreceptor odr-10 contributing to plasticity in food detection decision between exploration. adult hermaphrodites, high; well-fed males, low, promoting exploratory mate-searching Food-deprivation transiently activates male expression, heightening sensitivity reducing food-leaving. Here, we...