A5006180572- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Neuroendocrine regulation and behavior
- Animal Genetics and Reproduction
- Developmental Biology and Gene Regulation
University of Rochester
2021-2022
SUNY Brockport
2020
University of Baltimore
2019
The effect of the detailed connectivity a neural circuit on its function and resulting behavior organism is key question in many systems. Here, we study for nociception C. elegans, which composed same neurons two sexes that are wired differently. We show nociceptive sensory respond similarly sexes, yet animals display sexually dimorphic behaviors to aversive stimuli. To uncover role downstream network topology shaping behavior, learn simulate models replicate observed use them predict simple...
Despite the importance of dendritic targeting in neural circuit assembly, mechanisms by which it is controlled still remain incompletely understood. We previously showed that developing Drosophila antennal lobe, Wnt5 protein forms a gradient directs ~45˚ rotation cluster projection neuron (PN) dendrites, including adjacent DA1 and VA1d dendrites. report here Van Gogh (Vang) transmembrane planar cell polarity (PCP) required for DA1/VA1d pair. Cell type-specific rescue mosaic analyses Vang...
SUMMARY How sexually dimorphic behavior is encoded in the nervous system poorly understood. Here, we characterize nociceptive C. elegans and study underlying circuits, which are composed of same neurons but wired differently. We show that while sensory transduction similar two sexes, downstream network topology markedly shapes behavior. fit a model replicates observed response to external stimuli, use it predict simple rewirings would switch between sexes. then experimentally these subtle...
Despite the importance of dendritic targeting in neural circuit assembly, mechanisms by which it is controlled still remain incompletely understood. We previously showed that developing Drosophila antennal lobe, Wnt5 protein forms a gradient directs ~45° rotation cluster projection neuron (PN) dendrites, including adjacent DA1 and VA1d dendrites. report here Van Gogh (Vang) transmembrane planar cell polarity (PCP) required for DA1/VA1d pair. Cell type-specific rescue mosaic analyses Vang...
The effect of the detailed topology a neural circuit on its function and resulting behavior organism, is key question in many systems. Here, we study fundamental for nociception C. elegans, which composed same neurons two sexes, that are wired differently. We show sexes sense nociceptive cues similar manner, yet display sexually dimorphic behaviors to aversive stimuli. To uncover role downstream network shaping behavior, fit model replicates observed behaviors, use it predict simple...