A5050295219- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Infective Endocarditis Diagnosis and Management
- Oral health in cancer treatment
- Streptococcal Infections and Treatments
- Otolaryngology and Infectious Diseases
- Bone and Dental Protein Studies
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Immune cells in cancer
- Head and Neck Cancer Studies
- Osteomyelitis and Bone Disorders Research
- Fibroblast Growth Factor Research
Erasmus MC
2014-2023
KU Leuven
2018-2023
The development of alternatives for autologous bone grafts is a major focus tissue engineering. To produce living bone-forming implants, skeletal stem and progenitor cells (SSPCs) are envisioned as key ingredients. SSPCs can be obtained from different tissues including marrow, adipose tissue, dental pulp, periosteum. Human periosteum-derived (hPDCs) exhibit cell characteristics have well-documented in vivo formation potency. Here, we characterized compared hPDCs derived tibia with...
Bone fracture healing is a well-orchestrated but complex process that involves numerous regulations at different scales. This complexity becomes particularly evident during the inflammatory stage, as immune cells invade region and trigger cascade of signals to promote favorable regenerative environment. Thus, emergence criticalities this stage might hinder rest process. Therefore, investigation many interactions regulate inflammation has primary importance on exploration overall progression....
Treatment of large bone defects due to trauma, tumor resection, or congenital abnormalities is challenging. Bone tissue engineering using mesenchymal stem cells (MSCs) represents a promising treatment option. However, the quantity and quality engineered are not sufficient fill defects. The aim this study was determine if addition enamel matrix derivative (EMD) improves in vitro chondrogenic priming MSCs ultimately improve vivo MSC mediated endochondral formation.MSCs were chondrogenically...