A5045315073- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Biomedical Ethics and Regulation
- Neurogenesis and neuroplasticity mechanisms
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Herpesvirus Infections and Treatments
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Retinal Development and Disorders
- Mosquito-borne diseases and control
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Neuroscience and Neuropharmacology Research
- HIV Research and Treatment
- Biomedical and Engineering Education
- Axon Guidance and Neuronal Signaling
- Signaling Pathways in Disease
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Pancreatic function and diabetes
- Viral Infections and Vectors
- Alzheimer's disease research and treatments
Wellcome/MRC Cambridge Stem Cell Institute
2008-2021
Pfizer (United Kingdom)
2010-2017
Pfizer (United States)
2010
University of Edinburgh
1995-2006
University of St Andrews
1993-1995
St George's Hospital
1993-1994
Max Planck Institute for Developmental Biology
1990
Max Planck Society
1990
John Benjamins Publishing Company (Netherlands)
1975
A major goal of immunotherapy remains the control pathogenic T cell responses that drive autoimmunity and allograft rejection. Adherent progenitor cells, including mesenchymal stromal cells (MSCs) multipotent adult (MAPCs), represent attractive immunomodulatory therapy candidates currently active in clinical trials. MAPCs can be distinguished from MSCs on basis cellular phenotype, size, transcriptional profile, expansion capacity. However, despite their ongoing evaluation autoimmune...
A fast track "Hot Start" process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) provide early release of a range established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members surveyed arrive at harmonised publically accessible Standard Operations Procedures (SOPs) tissue procurement, bio-sample tracking, iPSC expansion, cryopreservation, qualification distribution research...
Abstract Developing neurons die if they fail to obtain an adequate supply of neurotrophins from their targets but how suppress cell death is not known. Although over‐expression exogenous Bcl‐2 can prevent the cultured deprived members nerve growth factor family it known this effect physiologically relevant. To determine participates in neurotrophin survival response we used antisense bcl‐2 RNA inhibit endogenous expression. Here show that brain‐derived neurotrophic (BDNF)‐dependent are...
As characterized by morphological assessment and terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling, Semliki Forest virus (SFV) infection of rat prostatic adenocarcinoma cells triggers an apoptotic cell response. Cell death proceeded more rapidly following with the neurovirulent L10 strain SFV than avirulent A7 strain. Overexpression antiapoptotic proto-oncogene bcl-2 allowed survival cultures infected either virus. overexpression drastically reduced numbers productively...
We have investigated the role of trkA, tyrosine kinase NGF receptor, in mediating survival response embryonic neurons to NGF. Embryonic trigeminal mesencephalic (TMN) neurons, which normally survive presence brain-derived neurotrophic factor (BDNF) but not NGF, become NGF-responsive when microinjected with an expression vector containing trkA cDNA. In contrast, microinjection ciliary (CNTF)-dependent same construct does result acquisition responsiveness by these despite de novo mRNA and...
This paper describes a decisional tool that is designed to identify cost-effective process designs for drug screening products derived from human induced pluripotent stem cells (hiPSC). The comprises bioprocess economics model linked search algorithm assess the financial impact of manual and automated bioprocessing strategies use 2D-planar tissue culture technologies. was applied case study examines production patient-specific iPSC-derived neurons screening. were compared across three...
Regenerative medicine research is focussed on the discovery of novel therapies (small molecules, biologics or cells) that restore function in damaged aging tissues and organs. The field underpinned by developments stem cell science modulation cells using small molecules now providing unique insights into regulation developmental biology. It has been shown can be used to help drive somatic reprogramming, maintain induced pluripotent states also directly control lineage specification...