A5072816177- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- Palliative Care and End-of-Life Issues
- Health and Medical Studies
- Force Microscopy Techniques and Applications
- Healthcare Systems and Practices
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- HIV/AIDS drug development and treatment
- Cancer Genomics and Diagnostics
- Tuberculosis Research and Epidemiology
- Radiopharmaceutical Chemistry and Applications
- Patient Dignity and Privacy
McGill University Health Centre
2019-2023
McGill University
2018-2021
Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) promote liver metastasis. In contrast, mature high-density inhibit the formation of metastases. Transcriptomic metabolomic analyses high- reveal engagement numerous metabolic pathways specifically in neutrophils. iLDNs exhibit enhanced global bioenergetic capacity, through...
Abstract In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths RCTs contribute to this gap. Clinicians should acknowledge the possibility a treatment effect when applying RCT results bedside care.
Abstract Importance Recent changes in guidelines for managing Clostridioides difficile infections (CDI) have placed fidaxomicin as a first-line treatment. Objective To estimate the net cost of compared to vancomycin American and Canadian healthcare systems price points at which would become saving prevention recurrence. Data sources study selection We identified randomized, placebo-controlled trials directly comparing with that reported on Medication costs were obtained from Veterans Affairs...
The p66ShcA redox protein is the longest isoform of Shc1 gene and variably expressed in breast cancers. In response to a variety stress stimuli, becomes phosphorylated on serine 36, which allows it translocate from cytoplasm mitochondria where stimulates formation reactive oxygen species (ROS). Conflicting studies suggest both pro- anti-tumorigenic functions for p66ShcA, prompted us examine contribution tumor cell-intrinsic during cancer metastasis.We tested whether impacts lung-metastatic...
SHC adaptor protein (SHCA) and lipoma-preferred partner (LPP) mediate transforming growth factor β (TGFβ)-induced breast cancer cell migration invasion. Reduced expression of either diminishes lung metastasis, but the reason for this effect is unclear. Here, using total internal reflection fluorescence (TIRF) microscopy, we found that TGFβ enhanced assembly disassembly rates paxillin-containing adhesions in an SHCA-dependent manner through phosphorylation specific SHCA tyrosine residues...
Abstract Background The benefits of remdesivir in the treatment hospitalized patients with Covid-19 remain debated National Institutes Health and World Organization providing contradictory recommendations for against use. Methods We performed a systematic review randomized controlled trials (RCTs) COVID-19. primary outcome was mortality, stratified by oxygen use (none, supplemental without mechanical ventilation, ventilation). conducted frequentist random effects meta-analysis on risk ratio...
Abstract Importance Recent changes in the Infectious Diseases and Healthcare Epidemiology Societies of America (IDSA-SHEA) guidelines for managing Clostridioides difficile infections (CDI) have placed fidaxomicin as first-line treatment. Objective To estimate net cost first line compared to vancomycin American Canadian healthcare systems price points at which would become saving. In Canada, costs were from public payer perspective. US, a Data sources We identified all randomized controlled...
Abstract Introduction: Src homology and collagen A (ShcA) adaptor proteins are essential during breast cancer progression. However, the role of largest isoform, p66ShcA, is conflicting still poorly understood. Under high levels stress p66ShcA phosphorylated on serine36, within its CH2 domain, allowing it to translocate mitochondria induce formation reactive oxygen species (ROS) promote apoptosis. Previously, we provided first in vivo evidence that can influence both pro anti-tumorigenic...
e23005 Background: In the early developmental phase of a post-mortem Rapid Tissue Donation (RTD) program for metastatic cancer patients, we surveyed health care professionals (HCPs) and oncology patients at McGill University Health Centre (MUHC) to assess their knowledge attitudes pertaining RTD from research purposes. Methods: A 23-item survey was developed distributed HCPs tumour board meetings, related 26-item MUHC Cedars Cancer Centre. Results: 73 HCPs, including 37 attending physicians,...
Additional file 5: Figure S5. p66ShcA does not alter the mesenchymal properties of 4T1-derived triple negative breast cancers. (A) Immunoblot analysis whole cell lysates isolated from 4T1-537 parental, p66-CR (VC), (WT) and (S36A) mammary tumors (n = 18 each) using ShcA-, E-Cadherin, Vimentin Tubulin-specific antibodies. (B-D) Densitometric quantification shown in panel A for (B) p66ShcA/Tubulin, (C) p66ShcA/p52ShcA, (D) E-Cadherin/Tubulin (E) Vimentin/Tubulin ratios. The data is normalized...