A5101426143- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Heat shock proteins research
- Voice and Speech Disorders
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- Ultrasonics and Acoustic Wave Propagation
- Genetic factors in colorectal cancer
- Cellular Mechanics and Interactions
- Dysphagia Assessment and Management
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Barrier Structure and Function Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Immunotherapy and Biomarkers
- Obstructive Sleep Apnea Research
- Nanoplatforms for cancer theranostics
- Flow Measurement and Analysis
- Ferroptosis and cancer prognosis
Industrial Technology Research Institute
2022-2023
Arsenal Biosciences (United States)
2023
McGill University
2015-2022
McGill University Health Centre
2018-2020
University of British Columbia
2020
Occupational Cancer Research Centre
2017
Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) promote liver metastasis. In contrast, mature high-density inhibit the formation of metastases. Transcriptomic metabolomic analyses high- reveal engagement numerous metabolic pathways specifically in neutrophils. iLDNs exhibit enhanced global bioenergetic capacity, through...
Abstract Introduction Breast cancer cells display preferences for specific metastatic sites including the bone, lung and liver. Metastasis is a complex process that relies, in part, on interactions between disseminated resident/infiltrating stromal constitute microenvironment. Distinct immune infiltrates can either impair or conversely, assist seeding, colonization growth of cells. Methods Using vivo selection approaches, we previously isolated 4T1-derived breast preferentially metastasize...
The translation of mRNAs into proteins serves as a critical regulatory event in gene expression. In the context cancer, deregulated is hallmark transformation, promoting proliferation, survival, and metastatic capabilities cancer cells. best-studied factor involved translational control eukaryotic initiation 4E (eIF4E). We others have shown that eIF4E availability phosphorylation promote metastasis mouse models breast by selectively augmenting invasion metastasis. However, impact cell types...
Germline mutations in STK11, which encodes the tumor suppressor liver kinase B1 (LKB1), promote Peutz-Jeghers syndrome (PJS), a cancer predisposition characterized by development of gastrointestinal (GI) polyps. Here, we report that heterozygous deletion Stk11 T cells (LThet mice) is sufficient to GI polyposis. Polyps from LThet mice, Stk11+/- and human PJS patients display hallmarks chronic inflammation, marked inflammatory immune-cell infiltration, signal transducer activator transcription...
// Sébastien Tabariès 1, 2 , Matthew G. Annis Brian E. Hsu Christine Tam Paul Savage Morag Park 2, 3, 4 Peter M. Siegel 3 1 Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada, H3A 1A3 Department of Medicine, Biochemistry, Oncology, Correspondence to: Siegel, e-mail: peter.siegel@mcgill.ca Keywords: breast cancer, liver metastasis, claudins, Src family kinase, Lyn Received: January 26, 2015 Accepted: 31,...
The p66ShcA redox protein is the longest isoform of Shc1 gene and variably expressed in breast cancers. In response to a variety stress stimuli, becomes phosphorylated on serine 36, which allows it translocate from cytoplasm mitochondria where stimulates formation reactive oxygen species (ROS). Conflicting studies suggest both pro- anti-tumorigenic functions for p66ShcA, prompted us examine contribution tumor cell-intrinsic during cancer metastasis.We tested whether impacts lung-metastatic...
Handheld ultrasound devices have been widely used for diagnostic applications. The use of the acoustic-field beamforming (AFB) method has proposed handheld to reduce electricity consumption and avoid battery unwanted heat issues. However, image quality, such as contrast ratio contrast-to-noise-ratio, are poorer with this technique than conventional delay-and-sum method. To address problems associated worse quality in AFB imaging, paper we propose an AFB-based generalized coherence factor...
Abstract Clinically effective adoptive T cell therapy for the treatment of solid tumors will require robust expansion, persistence, and potency. The Janus-kinase signal transducer activator transcription (JAK-STAT) pathway governs activation differentiation, can thereby serve as a critical regulator these properties. To take advantage benefits STAT signaling in programming an antitumor T-cell response, we used synthetic biology to create library proteins, termed Synthetic Pathway Activators...
Abstract The role of glycoprotein-NMB (GPNMB) in the immune system is varied. GPNMB expression macrophages and dendritic cells promotes innate responses, whereas GPNMB-expressing myeloid-derived suppressor (MDSC) suppress adaptive responses (T-cell function). While functional roles for expressed within are emerging, influence tumor-derived on landscape mammary tumors has not been well characterized. To investigate this further, we have generated two GPNMB-deficient breast cancer cell...