A5029022392- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Anesthesia and Pain Management
- Nerve Injury and Rehabilitation
- Shoulder and Clavicle Injuries
- Pediatric Pain Management Techniques
- Spinal Cord Injury Research
- Transcranial Magnetic Stimulation Studies
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Slime Mold and Myxomycetes Research
- Muscle activation and electromyography studies
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Ion channel regulation and function
- Automotive and Human Injury Biomechanics
- Sleep and Wakefulness Research
- Acupuncture Treatment Research Studies
Sprint PNS System (United States)
2019-2024
Medical Advanced Pain Specialists
2024
University of Pennsylvania
2010-2016
Duke University
2016
Background and objectives Chronic neuropathic pain is a common challenging condition following amputation. Recent research demonstrated the feasibility of percutaneously implanting fine-wire coiled peripheral nerve stimulation (PNS) leads in proximity to sciatic femoral nerves for postamputation pain. A multicenter, double-blinded, randomized, placebo-controlled study collected data on safety effectiveness percutaneous PNS chronic Methods Twenty-eight lower extremity amputees with were...
Peripheral nerve stimulation (PNS) has historically been used to treat chronic pain, but generally requires implantation of a permanent system for sustained relief. A recent study found that 60-day PNS treatment decreases post-amputation and the current work investigates longer-term outcomes out 12 months in same cohort.
Kilohertz-frequency spinal cord stimulation (KHF-SCS) is a potential paresthesia-free treatment for chronic pain. However, the effects of KHF-SCS on dorsal column (DC) axons and its mechanisms action remain unknown. The objectives this study were to quantify activation conduction block DC by across range frequencies (1, 5, 10, or 20 kHz) waveforms (biphasic pulses sinusoids). Custom platinum electrodes delivered SCS T10/T11 columns anesthetized male Sprague-Dawley rats. Single compound...
Spinal cord stimulation (SCS) is widely used to treat neuropathic pain. Burst SCS, an alternative mode of stimulation, reduces pain without paresthesia. However, the effects and mechanisms burst SCS have not been compared conventional tonic in controlled investigations. This study compares attenuation spinal neuronal activity tactile allodynia, role γ-aminobutyric acid (GABA) signaling during or a rat model cervical radiculopathy.The were by recording firing before after each at day 7...
Abstract Introduction Chronic pain and reduced function are significant problems for Military Service members Veterans following amputation. Peripheral nerve stimulation (PNS) is a promising therapy, but PNS systems have traditionally been limited by invasiveness complications. Recently, novel percutaneous system was developed to reduce the risk of complications enable delivery without surgery. Materials Methods Percutaneous evaluated determine if provides relief from residual phantom limb...
The aim of this study was to evaluate the efficacy and safety a 60-day peripheral nerve stimulation (PNS) treatment targeting occipital nerves for reducing pain improving function in individuals diagnosed with cervicogenic headache or neuralgia. Headache conditions are prevalent commonly disabling, conventional therapeutic strategies often insufficient. Development percutaneous PNS has created new opportunities nerves. This an institutional review board-approved, multicenter, prospective,...
Summary Joint afferent activity induces central sensitization after facet injury that can be prevented by transiently blocking firing within a critical period early injury. Cervical joint persistent pain and sensitization. Preventing the peripheral neuronal signals initiate attenuates neuropathic pain. Yet, there is no clear relationship among activity, development of sensitization, pain, which may hindering effective treatments for this syndrome. This study investigates how from injured...
Introduction & aim: Temporary (60-day) percutaneous peripheral nerve stimulation (PNS) has demonstrated effectiveness for the treatment of chronic post-amputation pain, and this pilot study aims to evaluate feasibility temporary PNS acute pain. Patients methods: Sixteen veterans undergoing lower extremity amputation received standard medical therapy or alone. Results: The group reported greater reductions in average phantom limb residual pain daily opioid consumption, there were fewer...
Conventional neurostimulation typically involves a brief (eg, ≤10-day) trial to assess presumed effectiveness prior permanent implantation. Low conversion rates and high explant due inadequate pain relief highlight the need for improved patient identification strategies. The development of 60-day percutaneous peripheral nerve stimulation (PNS) system enables evaluation outcomes following an extended temporary treatment period up 60 days, that may obviate or validate implant. present study...
Patients who present to pain clinics with complex regional syndrome (CRPS) typically have debilitating pain, including hyperalgesia and allodynia, additional substantial quality-of-life concerns related the motor autonomic-related symptoms of CRPS. Present treatments for CRPS such as neuropathic medications sympathetic blocks are often unsatisfactory managing symptoms. The cases highlight use a 60-day percutaneous peripheral nerve stimulation (PNS) treatment three patients Type I affecting...
Objective: This study presents real-world data from a cross-sectional follow-up survey of patients who previously received 60-day peripheral nerve stimulation (PNS) treatment for pain. Materials & methods: A including validated pain and other related outcome measures was distributed to underwent implantation temporary PNS leads treatment. Results: Among respondents were at least 3 months the start treatment, most reported sustained clinically significant improvements in and/or quality life,...
This real-world analysis aims to quantify improvements in multiple health domains patients who received 60-day peripheral nerve stimulation (PNS) for shoulder pain.
Immunohistochemistry labeled pre- and postsynaptic structural markers to quantify excitatory inhibitory synapses in the spinal superficial dorsal horn at 14 days after painful facet joint injury rat.The objective of this study was investigate relationship between pain synapse density cord injury.Neck is a major contributor disability often becomes chronic. The cervical joints are susceptible loading-induced injury, initiating central sensitization responses. Although plasticity has been...
The present IRB-approved retrospective chart review describes the use of a 60-day PNS treatment for shoulder pain at single center in 60 total consecutive patients.