- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Neurological disorders and treatments
- Computational Drug Discovery Methods
- HIV/AIDS drug development and treatment
- Botulinum Toxin and Related Neurological Disorders
- Analytical Methods in Pharmaceuticals
- Sepsis Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Parkinson's Disease and Spinal Disorders
- FOXO transcription factor regulation
- Mobile and Web Applications
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Appendicitis Diagnosis and Management
- Pregnancy and preeclampsia studies
- IoT and GPS-based Vehicle Safety Systems
- Female Genital Mutilation/Cutting Issues
- Neurogenesis and neuroplasticity mechanisms
- IoT-based Smart Home Systems
- Neurological and metabolic disorders
- Neurological Complications and Syndromes
- Neonatal Respiratory Health Research
University of Pennsylvania
2024
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2022-2023
John Wiley & Sons (United States)
2023
National Institute of Mental Health and Neurosciences
2022
Charotar University of Science and Technology
2021
Sankalchand Patel University
2021
Vidant Medical Center
2020
UF Health Shands Hospital
2018
University of Southern Queensland
2010
Johnson University
2007
This study explores the fast-progressing domain of Text-to-Image (T2I) synthesis, which aims to bridge gap between language and visual comprehension. The main emphasis is on crucial significance Generative Adversarial Networks (GANs), have transformed process image formation, with a specific impact conditional GANs. models enable controlled generation, their influence production high-quality images extensively analyzed. We propose novel method generating semantically aware embeddings from...
9576 Background: Anti-PD-1 therapy (aPD-1) has had significant clinical success in extending survivability of melanoma patients. However, two-third the patients do not achieve long-lasting benefits, and currently, there exists no reliable method for predicting response. We test whether monitoring melanoma-specific CD8 T cells blood, lymph node, tumor enables us to gain insights into mechanism resistance, identify potential predictive biomarkers. Methods: leveraged a phase 2 trial neoadjuvant...
<h3>Background</h3> Anti-PD-1 immunotherapy has emerged as a cornerstone in melanoma treatment, yet the precise nature of antigen-specific immune responses remains elusive. <h3>Methods</h3> Here, we present findings from neoadjuvant clinical trial employing single dose anti-PD-1 agent nivolumab stage III resectable patients. Paired tumor and blood specimens pre- post-treatment, along with both healthy tumor-invaded regional lymph nodes were analyzed. Employing combinatorial tetramer system,...
Deep brain stimulation (DBS) is the most widely used device-assisted therapy in patients with moderately advanced stages of Parkinson's disease (PD) experiencing motor complications. Only a minority eligible get opportunity to undergo DBS developing world.
Aims: Dolutegravir (DVR) and Lamivudine (LMN) is anti-viral drug combination used in treatment of HIV-I infection. FDA approved dosage regime for DVR LMN 50mg 300mg respectively. The aim present research work to develop validate a reverse phase high performance liquid chromatography (RP-HPLC) method simultaneous estimation bulk pharmaceutical forms. Further the stability indicating nature has been evaluated.
 Methodology: A chromatographic separation was achieved on Hypersil BDS C18,...
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. Eye movement abnormalities are characteristic manifestations of HD. The clinical and eye disturbances progress with the natural course illness. evolve in HD from premanifest stage to early-manifest late-manifest stages. In stage, voluntary saccades, i.e., memory-guided saccades anti-saccades predominantly affected. There increase latency error rates saccades. Early-manifest characterized by abnormality reflexive...
This project aims to provide an in-depth technical in-sight into development of innovative student attendance recording application using emerging communication technologies. Development the Voice-over-IP Student Attendance Recording Application (VoIP SARA) for Box Hill Institute TAFE (BHI) is presented. demonstrates programming, test bed setup, design considerations, decisions and future plans, as well creative usage communications The developed combines Cisco VoIP telephony network...
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Objective: Evaluation of the viability office hysteroscopy in an Indian context at a single center.To encourage budding gynecologists to perform hysteroscopy, which is possible with successful results correct strategy, method, and setting.Methods: Observational analysis retrospect.Between January 2011 2022, 4827 women had our center.Around 1627 instances Bettocchi 2.9 scope Hamou endomat were performed from 2022 3200 hysteroscopies 1.9 Endometrial automatic suction irrigation system (EASI)...
Propriospinal myoclonus (PSM) is characterized by predominant axial jerk-like movements. To date, most of the PSM cases reported in literature are considered to be functional (psychogenic) origin. The “huffing and puffing sign” a clinical clue with high diagnostic specificity for etiology gait disorders. However, this sign has not yet been described patients PSM. Here, we report case etiology, coexisting disorder sign.” Our adds list clues that suggest
Anti N-methyl D-aspartate (NMDA) receptor encephalitis is the most common autoimmune affecting young adults (median age of 21 years, range 1-85 years) and females (8:2 ratio).[1] The patients present with sleep disturbances, neuropsychiatric disorders, seizures or status epilepticus, abnormal movements, memory behavioral disturbances. Autonomic disturbances like tachycardia, bradycardia, bradyarrhythmia, cardiac asystole, tachyarrhythmia, hypothermia, hyperhidrosis, hypertension are commonly...
Hemifacial spasm is a common peripheral movement disorder that usually results from neurovascular conflict involving the facial nerve motor root exit zone. Although it sporadic disease, some cases of familial clustering have been reported. In this case report, we present occurrence hemifacial with dolichoectasia vertebrobasilar system in three siblings. The patients responded well to botulinum toxin therapy. A genetic mechanism predisposing them vascular abnormalities likely be responsible...
Aims: The present research was aimed to develop and validate a reverse phase high performance liquid chromatographic (RP-HPLC) method for the quantification of Emtricitabine (EMT) Tenofovir Alafenamide (TEN) in combination.
 Methodology: Separation achieved under optimized condition on an Inertsil C18, 250 x 4.6 mm, 5μm column. Various composition mobile tried. EMT TEN started with Methanol: Buffer Methanol finally using solvent system (pH 3.5) ratio (30:70) flow rate adjust at 1.0...