A5072531871- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- MicroRNA in disease regulation
- Protease and Inhibitor Mechanisms
- Statistical Methods and Inference
- COVID-19 and Mental Health
- Statistical Methods and Bayesian Inference
- Infant Development and Preterm Care
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Optical Coherence Tomography Applications
- Genomics and Phylogenetic Studies
- Transcranial Magnetic Stimulation Studies
- Advanced Fluorescence Microscopy Techniques
- Enzyme Production and Characterization
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- Psychological Well-being and Life Satisfaction
- Peptidase Inhibition and Analysis
- Legume Nitrogen Fixing Symbiosis
- Lipoproteins and Cardiovascular Health
- Cytomegalovirus and herpesvirus research
- Blood Pressure and Hypertension Studies
- Statistical Distribution Estimation and Applications
- Digital Holography and Microscopy
Stony Brook University
2012-2023
Lomonosov Moscow State University
2021-2023
University of Pennsylvania
2003-2022
University of Georgia
2020-2022
Northwestern University
2022
University of Washington
2021-2022
University of California, Los Angeles
2020
Masonry Society
2020
Andrews University
2019
Hospital of the University of Pennsylvania
2019
Upregulation of matrix metalloproteinase MMP-14 (MT1-MMP) is associated with poor prognosis in cancer patients, but it unclear how becomes elevated tumors. Here, we show that miR-181a-5p downregulated aggressive human breast and colon cancers where its levels correlate inversely expression. In clinical specimens, enhanced expression was observed cells located at the invasive front tumors relative to adjacent normal cells. Bioinformatics analyses defined a potential response element within...
Visualizing diverse anatomical and functional traits that span many spatial scales with high spatio-temporal resolution provides insights into the fundamentals of living organisms. Light-field microscopy (LFM) has recently emerged as a scanning-free, scalable method allows for high-speed, volumetric brain imaging. Given those promising applications at tissue level, its other extreme, this highly-scalable approach holds great potential observing structures dynamics in single-cell specimens....
Most studies of HLA sensitization after red blood cell transfusion in transplant candidates were done before widespread use leuko reduced and based on relatively insensitive, nonspecific antibody assays. We evaluated the effect breadth magnitude formation using current, sensitive, HLA-specific immunoassays.Serial data merged with from US Renal Data System for 1324 patients kidney wait list (2004-2010). Two study groups identified: a matched cohort consisting 89 who received 251 did not...
Emerging evidence has demonstrated that upregulated expression of KIAA1199 in human cancer bodes for poor survival. The regulatory mechanism controlling remains to be characterized. In the present study, we have isolated and characterized promoter terms regulation gene expression. A 3.3 kb fragment genomic DNA containing 5'-flanking sequence possesses both suppressive activating elements. Employing a deletion mutagenesis approach, 1.4 proximal region was defined as basic TATA-box close...
Using a nonclinical, noncollege sample, this study set out to confirm and extend previous findings of relationship between the cognitive-perceptual features schizotypal personality mixed handedness using Schizotypal Personality Questionnaire (SPQ). Based on relationships nondextrality thought disorder in schizophrenia, it was predicted that odd speech subscale SPQ would have strongest with handedness. Mixed-handed adults did significantly higher scores than right-handed left-handed factor...
We evaluated safety, antiviral, immunomodulatory and anti-inflammatory properties of aprepitant - a neurokinin 1 receptor antagonist.Phase IB randomized, placebo-controlled, double-blinded study.Eighteen patients were randomized (nine to nine placebo). The received once-daily treatment (375 mg or placebo by oral administration) for 2 weeks followed off drug 4 weeks.There no significant changes in the plasma viremia CD4(+) T cells during dosing period. Aprepitant was associated with decreases...
Rhizobia are best known for nodulating legume roots and fixing atmospheric nitrogen the host in exchange photosynthates. However, majority of diverse strains rhizobia do not form nodules on legumes, often because they lack key loci that needed to induce nodulation. Nonnodulating robust heterotrophs can persist bulk soil, thrive rhizosphere, or colonize as endophytes, but their role legume-rhizobium mutualism remains unclear. Here, we investigated effects nonnodulating native...
Care of patients with pulmonary hypertension is complex. Although vasodilators are effective for Group 1 hypertension, clinical guidelines and the Choosing Wisely Campaign recommend against routine use Groups 2 3 (the most common types hypertension) because a lack benefit, potential harm, high cost ($10,000-$13,000 per patient year treated). Little known about how these medications used in practice.To determine national patterns phosphodiesterase-5 inhibitor prescribing Veterans Health...
Current guidelines for the management of hepatitis C virus (HCV) infections provide varying recommendations optimal treatment acute HCV infections. There are limited data from small cohort studies to guidance on best approach this important patient population.
Patients with chronic ataxia resulting from traumatic central nervous system (CNS) damage frequently attain a gait pattern dependent upon upper extremity weight-bearing (UEWB). Traditional attempts to train these patients may perpetuate UEWB dependency, by not allowing optimal facilitation of balance and associated movement control required for independent ambulation. In the present study an ambulation retraining approach designed facilitate coordination while minimizing was used. This can...
Background Neurokinin-1 receptor (NK1R) antagonists have anti-HIV activity in monocyte-derived macrophages, decrease CCR5 expression and improve natural killer cell function ex vivo. Aprepitant is a NK1R antagonist approved by FDA as an antiemetic. Methods We conducted phase IB randomized, placebo controlled, double masked study to evaluate the safety, antiviral activity, pharmacokinetics immune-modulatory effects of aprepitant HIV-infected adults not receiving antiretroviral therapy, with...
<b><i>Background/Aims:</i></b> Predialysis care has been associated with improved first-year outcomes. We investigated types of predialysis patient outcomes in patients initiating dialysis a fistula and at least 2 years care. <b><i>Methods:</i></b> In this retrospective cohort incident hemodialysis ≥2 Medicare coverage before initiation, patterns were determined using claims. Fistula use initiation was ascertained from the Medical Evidence...
Electroconvulsive therapy (ECT) is recommended by the American Psychiatric Association Task Force on ECT as a safe and effective treatment of depression throughout pregnancy. We report here administration in third trimester pregnancy 33-year-old patient with severe bipolar depression. The had good antidepressant response to ECT. She experienced, however, delayed onset premature uterine contractions at home after her sixth session (10 hours post-ECT administration). After receiving...
HIV-infected individuals, even well controlled with combined antiretroviral therapy (cART), have systemic inflammation and comorbidities. Substance P (SP) is an undecapeptide, which mediates neurotransmission through its cognate neurokinin 1 receptor (NK1R). Plasma SP levels are elevated in individuals. The FDA-approved antiemetic aprepitant, NK1R antagonist, has anti-HIV effects antiinflammatory actions. We evaluated the safety, pharmacokinetics, properties of aprepitant HIV-positive...
Gammaherpesviruses encode proteins with homology to the cellular purine metabolic enzyme formyl-glycinamide-phosphoribosyl-amidotransferase (FGARAT), but role of these viral FGARATs (vFGARATs) in pathogenesis a natural host has not been investigated. We report novel for ORF75A vFGARAT murine gammaherpesvirus 68 (MHV68) infectious virion production and colonization mice. MHV68 mutants premature stop codons orf75A exhibited log reduction acute replication lungs after intranasal infection,...