A5007041125- Dementia and Cognitive Impairment Research
- Maternal Mental Health During Pregnancy and Postpartum
- Alzheimer's disease research and treatments
- Eating Disorders and Behaviors
- Child Abuse and Trauma
- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Migration, Health and Trauma
- Neurobiology of Language and Bilingualism
- Biochemical Analysis and Sensing Techniques
- Suicide and Self-Harm Studies
- Olfactory and Sensory Function Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pregnancy-related medical research
- Maternal and Perinatal Health Interventions
- Memory Processes and Influences
- Traumatic Brain Injury Research
- Neuroscience and Music Perception
- Menstrual Health and Disorders
- Grief, Bereavement, and Mental Health
- S100 Proteins and Annexins
- Regulation of Appetite and Obesity
University of North Carolina at Chapel Hill
2013-2025
University of Cincinnati
2004-2012
Cincinnati Children's Hospital Medical Center
2008
National Institute of Mental Health
1992-2006
Northwell Health
2006
National Institutes of Health
1992-2006
National Institute of Neurological Disorders and Stroke
2006
Maryland Oncology Hematology
2005
University of Pittsburgh
2003
University of Arizona
1999-2001
Objective: Individuals with anorexia nervosa are known to be ascetic and able sustain self-denial of food as well most comforts pleasures in life. Building on previous findings altered striatal dopamine binding nervosa, the authors sought assess response anterior ventral striatum reward loss this disorder. Method: Striatal responses a simple monetary task were investigated using event-related functional magnetic resonance imaging. To avoid confounding effects malnutrition, compared 13...
Abstract It has been argued that the role of hippocampus in memory is time‐limited: during a period consolidation, other brain regions such as neocortex are said to acquire ability support retention and retrieval on their own. An alternative view for autobiographical episodes depend hippocampal complex, regardless age memory. We examined participation complex functional magnetic resonance imaging (fMRI) study which participants were asked recollect events occurred either within last 4 years...
Numerous studies find a cumulative effect of different types childhood adversities on increasing risk for serious adult mental and medical outcomes. This study uses the National Comorbidity Survey‐Replication sample to investigate impact 8 complex psychopathology as indexed by (a) number lifetime diagnoses according Diagnostic Statistical Manual Mental Disorders (4th ed., DSM‐IV ; American Psychiatric Association, 1994); (b) 4 disorder categories (mood, anxiety, impulse control, substance...
Abstract Aims It remains unclear whether the coronavirus disease 2019 (COVID-19) pandemic is having an impact on suicide rates (SR). Economic insecurity and mental disorders are risk factors for suicide, which may increase during pandemic. Methods Data events in a major city Germany, corresponding life years (LY) were provided by local authorities. For year 2020, periods without restrictions freedom of movement social contact compared with moderate severe COVID-19 restrictions. To avoid...
Previous studies in animals indicate that reproductive steroids are potent modulators of the hypothalamic-pituitary-adrenal (HPA) axis, a physiologic system is typically dysregulated affective disorders, such as major depression. Determination role HPA axis regulation humans importance when attempting to understand pathophysiology premenstrual syndrome (PMS), disorder characterized by symptoms during luteal phase menstrual cycle. We performed two using treadmill exercise stress testing...
Recent studies have raised the question as to whether a dysregulation of neurotransmitter serotonin may contribute alterations in mood seen anorexia nervosa (AN). People with AN tend be anxious, obsessional, perfectionistic, and harm avoidant. These traits are premorbid persist after recovery. It has been suggested that increased activity brain systems could this pathologic condition. Dieting AN, which serves reduce plasma levels tryptophan (TRP), serve symptoms dysphoric mood.Fourteen women...
Abstract Objective: It is possible that disturbances of systems modulating reward may contribute to a vulnerability develop an eating disorder. Method: This hypothesis was tested by assessing functional magnetic resonance brain imaging response monetary task known activate the anterior ventral striatum (AVS), region implicated in motivational aspects toward stimuli. To avoid confounding effects malnutrition, 10 women who had recovered from bulimia nervosa (BN) were compared with healthy...
We describe a multiyear pilot dissemination of trauma-focused group treatment, Trauma and Grief Component Therapy for Adolescents, coupled with trauma-informed staff training, Think Trauma, to six residential juvenile justice (JJ) facilities. All members were trained in Trauma. Seventy-seven youth from four facilities completed the treatment groups 69 all pre- postgroup assessment measures. The aims this study determine whether interventions (a) could be implemented complex JJ systems, (b)...
Abstract Individuals with dissociative disorders (DDs) are underrecognized, underserved, and often severely psychiatrically ill, characterized by marked posttraumatic stress disorder (PTSD) symptoms significant disability. Patients DD have high rates of nonsuicidal self‐injury (NSSI) suicide attempts. Despite this, there is a dearth training about DDs. We report the outcome web‐based psychoeducational intervention for an international sample 111 patients diagnosed identity (DID) or other...
To assess the impact of antecedent trauma on risk antenatal and postpartum depression in a prospective, longitudinal cohort pregnant women.374 participants (pregnant women aged 20-34 years) were recruited from hospital-based obstetrics practice serving predominantly low-income, inner-city population between May 2007 2012. Clinical diagnostic interviews psychosocial questionnaires administered at 18 32 weeks gestation 6 months postpartum. Lifetime exposure to details traumatic events...
Evidence-based treatments are urgently needed for individuals with trauma-related dissociation (TRD), including severe dissociative disorders, the posttraumatic stress disorder (PTSD) subtype, and complex PTSD (International Classification of Diseases-10). TRD is strongly associated trauma, a more refractory treatment course, high suicidality nonsuicidal self-injury. We evaluated changes in symptoms adaptive capacities through participation an adjunctive online program based on Finding Solid...
Sex-related differences in the stress response are well described animal literature but humans inconsistent and appear to reflect both method used stimulate hypothalamic-pituitary-adrenal (HPA) axis age of subjects. reproductive steroid levels further confound efforts define specific role sex individual responsivity.The aim this study was address independent levels. We compared HPA pharmacological (CRH) physiological (exercise) stressors two groups young middle-aged (18-45 yr) men (n = 10 8)...