A5101689297- Extracellular vesicles in disease
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Medicinal plant effects and applications
- Microbial Metabolism and Applications
- Electron Spin Resonance Studies
- Drug Transport and Resistance Mechanisms
- Pickering emulsions and particle stabilization
- Redox biology and oxidative stress
- Complement system in diseases
- Diabetic Foot Ulcer Assessment and Management
- Lung Cancer Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Botanical Studies and Applications
- Plant-based Medicinal Research
- Proteins in Food Systems
- Infectious Diseases and Tuberculosis
- Renal Transplantation Outcomes and Treatments
- Macrophage Migration Inhibitory Factor
- Phytochemistry and Bioactivity Studies
- Neonatal Health and Biochemistry
- interferon and immune responses
- Pediatric health and respiratory diseases
- Galectins and Cancer Biology
- Systemic Lupus Erythematosus Research
China Pharmaceutical University
2023-2025
Tianjin Medical University
2013-2024
Zhengzhou University
2021-2023
Second Affiliated Hospital of Zhengzhou University
2023
Shanghai Jiao Tong University
2023
Wuhan Children's Hospital
2020
Huazhong University of Science and Technology
2020
Weifang Medical University
2020
Boston Children's Hospital
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Ganoderma lucidum was studied for its antioxidative activity by bioassay guided isolation in conjunction with vitro tests. The powdered crude drug treated boiling water and the aqueous extract (Ex1) further separated to obtain terpene polysaccharide fractions. two fractions Ex1 were screened their effect against pyrogallol induced erythrocyte membrane oxidation Fe (II)-ascorbic acid lipid peroxidation. All tested samples showed activities a dose dependent manner fraction found possess...
Antimony selenide (Sb2Se3) exhibits outstanding photoelectric characteristics and has significant potential for application in photovoltaic devices. However, Sb2Se3 solar cells are hindered by severe carrier combinations at both the heterojunction...
Fatigue is synonymous with a wide spectrum of familiar physiological conditions, from pathology and general health, to sport physical exercise. Strenuous, prolonged exercise training causes fatigue. Although several studies have investigated the effects electrical stimulation frequency on muscle fatigue, percutaneous pulse current fatigue in hepatic tissue trained rats still unclear. In order find an effective strategy prevent or enhance recovery, endurance its anti-fatigue properties...
Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. The present study aims (1) identify GAA metabolites, in vivo by analyzing the bile, plasma urine after intravenous administration rats (20 mg/kg), vitro incubating with rat liver microsomes (RLMs) human (HLMs); (2) investigate metabolic kinetics of main metabolites. Using HPLC-DAD-MS/MS...
Bioreduction of spin labels and polarizing agents (generally stable radicals) has been an obstacle limiting the in-cell applications pulsed electron paramagnetic resonance (EPR) spectroscopy dynamic nuclear polarization (DNP). In this work, we have demonstrated that two semiquinone methide radicals (OXQM⋅ CTQM⋅) can be easily produced from trityl-based quinone methides (OXQM CTQM) via reduction by various reducing including biothiols ascorbate under anaerobic conditions. Both relatively low...
Diabetic foot (DF) is a common complication of diabetes with insidious onset, making it difficult for patients to receive timely diagnosis and treatment. This study aimed evaluate the change in lipoprotein-associated phospholipase A2 (Lp-PLA2) interleukin-18 (IL-18) serum type 2 mellitus (T2DM) pa-tients without DF, thereby assessing association between progression DF levels Lp-PLA2 together IL-18.In this study, 50 ulcers (group I, T2DM group), 135 II, 30 matched healthy controls III) were...
Purpose: Many exopolysaccharides (EPS) have significant emulsifying activity. Some EPS produced by the marine bacterial strain FYS stronger activity in form of nanoparticles, suggesting that they could potentially Pickering emulsions. We prepared novel EPS/CT nanoemulsions (ECPN) with as emulsifiers and assessed their ability to ameliorate poor permeability calcipotriol (CT) skin affected psoriasis vulgaris. Methods: A bacterium was identified. Molecular weight, monosaccharide composition...
Functional <i>CYP3A4*1G</i> (G>A, rs2242480) in cytochrome P450 <i>3A4</i> (<i>CYP3A4</i>) regulates the drug-metabolizing enzyme <i>CYP3A4</i> expression. The objective of this study was to investigate whether both basal and rifampicin (RIF)-induced expression activity <i>CYP3A5</i> gene-edited human HepG2 cells. GG AA genotype cells were established using clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) single nucleotide polymorphism...
Glycosylation of proteins is an essential feature extracellular vesicles (EVs). However, while the glycosylation heterogeneity focusing on specific EV subtypes and will better reveal functions EVs, determination their glycans remains highly challenging. Herein, we report a method protein-specific glycan recognition using DNA-encoded affinity ligands to label glycans. Manipulating sequences DNA tags employing logic gate trigger spatial proximity-induced replacement reaction enabled release...
Objective The purpose of this article was to investigate whether the combination urinary beta 2 microglobulin (urinary β2-MG) and procalcitonin (PCT) diagnosis could enhance localization diagnostic precision pediatric tract infection comparing with single diagnosis. Methods A study conducted in Nephrology Department Wuhan women children's health care centre. This incorporated 85 participants, including 35 children who were diagnosed as upper (UUTI) symptom fever 50 lower (LUTI). Levels PCT...
Aim: To evaluate the renal outcomes and prognostic factors among patients with type-2 diabetes (T2D) biopsy-confirmed diabetic nephropathy (DN), non-diabetic disease (NDRD) DN mixed NDRD (MIX). Design Methods: Patients both T2D chronic kidney (CKD) who underwent biopsy between January 2014 December 2016 were recruited in this prospective observational study. Participants divided into group, or MIX group according to baseline pathological diagnosis. The primary endpoint was a composite event...
Reactive sulfur species (RSS) including persulfides (RSSHs), biothiols, and hydrogen sulfide (H
Both Western and Chinese medicine have their own advantages in treating chronic osteomyelitis. In this study, we investigated the methods clinical effect of osteomyelitis treated by integrated Chinese-Western therapy. This is a prospective study. A total 121 cases (treated Military Training Medicine Institute hospital from January, 2002 to February, 2010) were divided into three groups, respectively with traditional medicine, All patients followed up ranged 8 56 months, an average 30 months....
Objective To explore the clinical efficacy of Naikan cognitive therapy(NCT) for alcohol dependent patients. Methods 64 cases alcohol-dependent patients were randomly assigned to study group (32 cases) and control cases). The was treated with NCT successive 7 days on basis taking original drugs; only given drug therapy. obsessive compulsive drinking scale (OCDS), self-report symptom inventory(SCL-90), nurses observation inpatient evaluation(NOSIE) administered all subjects at pre-and...