A5053437261- Pediatric Pain Management Techniques
- Infant Development and Preterm Care
- Vaccine Coverage and Hesitancy
- EEG and Brain-Computer Interfaces
- Anesthesia and Sedative Agents
- Inflammatory mediators and NSAID effects
- Neonatal and fetal brain pathology
- Infant Health and Development
- Global Health Care Issues
- Healthcare Policy and Management
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Microscopic Colitis
- Health Systems, Economic Evaluations, Quality of Life
- Functional Brain Connectivity Studies
- Viral Infections and Outbreaks Research
- Inflammatory Bowel Disease
- Pain Mechanisms and Treatments
- Advancements in Transdermal Drug Delivery
- Respiratory and Cough-Related Research
- Viral gastroenteritis research and epidemiology
- Drug-Induced Adverse Reactions
- Pregnancy and Medication Impact
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
Barrie Urology Group
2024
University of Oxford
2020-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023
MSD K.K. (Japan)
2023
Reckitt Benckiser (United Kingdom)
2017-2020
John Radcliffe Hospital
2009-2017
Ferring Pharmaceuticals (Switzerland)
2007
Royal London Hospital
1994
St Andrew's Healthcare
1994
Queen Mary University of London
1994
Touch interventions such as massage and skin-to-skin contact relieve neonatal pain. The Parental touch trial (Petal) aimed to assess whether parental stroking of their baby before a clinically required heel lance, at speed approximately 3 cm/s optimally activate C-tactile nerve fibres, provides effective pain relief.
Parental involvement in neonatal comfort care is a core component of family-centred care. Yet, parents experience range positive and negative feelings when providing pain-relieving interventions for their infants. Parents infants who participated the touch trial ( Petal ), multicentre randomised controlled investigating impact gentle parental on pain, were asked to complete an anonymous survey. This survey aimed (1) explore parent-reported motivations deciding participate trial; (2)...
Abstract Immune function and sensitivity to pain are closely related, but the association between early life inflammation sensory nervous system development is poorly understood—especially in humans. Here, term-born infants, we measure brain activity reflex withdrawal (using EEG EMG) behavioural physiological PIPP-R score) assess impact of suspected early-onset neonatal infection on tactile- noxious-evoked responses. We present evidence that (assessed by measuring C-reactive protein levels)...
Electroencephalography (EEG) can be used to estimate neonates' biological brain age. Discrepancies between postmenstrual age and age, termed the gap, potentially quantify maturational deviation. Existing EEG models are not well suited clinical cot-side use for estimating gap due their dependency on relatively large data pre-processing requirements.
Introduction Newborn infants routinely undergo minor painful procedures as part of postnatal care, with born sick or premature requiring a greater number procedures. As pain in early life can have long-term neurodevelopmental consequences and lead to parental anxiety future avoidance interventions, effective management is essential. Non-pharmacological comfort measures such breastfeeding, swaddling sweet solutions are inconsistently implemented not always practical reducing the transmission...
Abstract The pharmacokinetics of a novel locally applied ibuprofen topical patch was evaluated. Healthy subjects (n = 28) were administered 200‐mg every 24 hours for 5 days, and steady‐state determined. amount remaining in the following each removal also assessed. maximum drug concentration area under curve from time 0 on day (t 0) to 24‐hours sample 6 514 ng/mL (95% CI 439 603 ng/mL) 9.78 kg·h/mL 8.43 11.4 kg·h/mL), respectively. Maximum occurred at 20 post–patch application. No evidence...
Abstract The preterm neonate can experience stressors that affect the rate of brain maturation and lead to long-term neurodevelopmental deficits. However, some neonates who are born early follow normal developmental trajectories. Extraction data from electroencephalography (EEG) signals be used calculate neonate’s age which compared their true age. Discrepancies between (the delta) then quantify maturational deviation, has been shown correlate with abnormal outcomes. Nevertheless, current...
Electroencephalography (EEG) can be used in neonates to measure brain activity changes that are evoked by noxious events, such as clinically required immunisations, cannulation and heel lancing for blood tests. EEG provides an alternative approach infer pain experience infants compared with more commonly behavioural physiological assessments. Establishing the generalisability construct validity of these measures will help corroborate use brain-derived outcomes evaluate efficacy new or...
Objective: To conduct an economic evaluation of terlipressin, octreotide and placebo in the treatment bleeding oesophageal varices (BOV) where endotherapy could be used concomitantly.Methods: A discrete event simulation model was created with transition states: bleeding, no post transjugular intrahepatic portosystemic shunt, post-salvage surgery, death. Efficacy data on survival, re-bleeding control were obtained from high quality studies reported Cochrane meta-analyses. Baseline outcomes...
Ibuprofen is used for the treatment of non-serious pain. This study assessed efficacy and safety a new ibuprofen plaster pain associated with acute sports impact injuries/contusions.In this randomised, double-blind, multi-centre, placebo controlled, parallel group study, adults (n = 130; 18-58 years age) diagnosed sports-related blunt soft tissue injury/contusion were randomized to receive either 200 mg or plaster. Plasters administered once daily five consecutive days. The primary...
To investigate the efficacy and safety of a recently developed ibuprofen medicated plaster in treatment acute sports impact injuries/contusions.In this double-blind, multi-center, placebo-controlled, parallel group, phase 3 study (EudraCT Number: 2012-003257-2) patients (n = 132; ages 18 to 60 years) diagnosed with sports-related traumatic blunt soft tissue injury/contusion upper or lower limbs were randomized receive either 200 mg 64) placebo 68). Plasters administered once daily for five...
Numerous approaches are used to estimate indirect productivity losses using various wage estimates applied poor health in working aged adults. Considering the different estimation observed published literature, we sought assess variation loss when average wages compared with age-specific wages.Published for and combined male/female were obtained from UK Office of National Statistics. A polynomial interpolation was convert 5-year age-banded data into annual estimates. To compare cost...
Abstract Objective . Automated detection of artefact in stimulus-evoked electroencephalographic (EEG) data recorded neonates will improve the reproducibility and speed analysis clinical research compared with manual identification artefact. Some studies use very short, single-channel epochs EEG little per infant—for example because vulnerability infants limits access for recording. Current artefact-detection methods that perform well on adult resting-state multi-channel are not suitable this...