Dacre Knight

ORCID: 0000-0001-6206-0680
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About
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Research Areas
  • Connective tissue disorders research
  • Long-Term Effects of COVID-19
  • COVID-19 and Mental Health
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Dermatological and Skeletal Disorders
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 and healthcare impacts
  • Peptidase Inhibition and Analysis
  • COVID-19 Clinical Research Studies
  • Psychosomatic Disorders and Their Treatments
  • Telemedicine and Telehealth Implementation
  • Intensive Care Unit Cognitive Disorders
  • Shoulder Injury and Treatment
  • SARS-CoV-2 detection and testing
  • Dupuytren's Contracture and Treatments
  • Musculoskeletal pain and rehabilitation
  • Health, psychology, and well-being
  • Bone health and treatments
  • Diagnosis and Treatment of Venous Diseases
  • Myofascial pain diagnosis and treatment
  • Hospital Admissions and Outcomes
  • Cannabis and Cannabinoid Research
  • Hereditary Neurological Disorders
  • Hip disorders and treatments
  • Medical Coding and Health Information

WinnMed
2021-2024

Mayo Clinic in Florida
2020-2024

Jacksonville College
2020-2024

Foundation for Medical Research
2021

ObjectiveTo evaluate physician perceptions and attitudes toward telemedicine use at a tertiary care academic institution in northeast Florida during the coronavirus disease 2019 pandemic.Patients MethodsAn anonymous 38-question cross-sectional survey was developed using Qualtrics software (Qualtrics) e-mailed to all staff physicians from specialty disciplines Mayo Clinic Florida. The open August 17, 2020, through September 1, 2020. Collected data included general demographic characteristics...

10.1016/j.mayocpiqo.2021.06.006 article EN cc-by-nc-nd Mayo Clinic Proceedings Innovations Quality & Outcomes 2021-07-01

Background Joint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms comorbidities overlap diagnosed hEDS/HSD and/or Methods We retrospectively examined self-reported data from an EDS Clinic intake questionnaire hEDS/HSD, fibromyalgia, or both vs. controls emphasis on joint issues. Results From 733 seen at the Clinic, 56.5% ( n = 414) were...

10.3389/fmed.2023.1096180 article EN cc-by Frontiers in Medicine 2023-04-25

Defective connective tissue structure may cause individuals with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD) to develop cardiac defects.

10.3389/fcvm.2024.1332508 article EN cc-by Frontiers in Cardiovascular Medicine 2024-03-18

Introduction Patients with Ehlers-Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD) have significant health challenges that are well-documented, however their impact in terms of cost is not known. Our research objective was to examine the burden EDS HSD United States. We focused this analysis on those commercial insurance plans. Methods queried MarketScan® database for year 2021 claims contained an ICD-10 diagnosis code or hypermobility. Excess costs patients cohorts were...

10.3389/fpubh.2024.1365712 article EN cc-by Frontiers in Public Health 2024-07-03

Large language models (LLMs) have emerged as a major force in artificial intelligence, demonstrating remarkable capabilities natural processing, comprehension, and text image generation. Recent advancements led to the development of LLMs specifically designed for medical applications, showcasing their potential revolutionize healthcare. These can analyze complex scenarios, assist diagnoses, provide treatment recommendations. However, evaluating accuracy reliability medicine remains crucial...

10.1101/2025.04.07.25325385 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2025-04-07

Abstract Large language models (LLMs) have emerged as a dominant form of generative artificial intelligence (GenAI) in multiple domains. In early 2025, DeepSeek R1 was released, which is new large reasoning model (LRM) that includes CoT (CoT) reasoning, Mixture Experts (MoE), and reinforcement learning. As these technologies continue to improve, evaluating the accuracy reliability LLMs LRMs medicine remains crucial challenge. This paper reports on follow-up study using evaluate medical...

10.1101/2025.04.29.25326666 preprint EN cc-by-nc medRxiv (Cold Spring Harbor Laboratory) 2025-04-30

Because most cases of coronavirus disease 2019 (COVID-19) are not severe, understanding the epidemiology mild has important clinical implications. We aimed to describe symptom profile and associated outcomes in a virtual outpatient COVID-19 clinic. conducted prospective cohort study from March through June 2020. included 106 patients with positive results for SARS-CoV-2, followed up until they had 2 sequential negative tests. Exploratory regression analyses identified potential prognostic...

10.1007/s42399-021-00746-1 article EN other-oa SN Comprehensive Clinical Medicine 2021-01-01

10.14423/smj.0000000000001283 article EN Southern Medical Journal 2021-08-01

Abstract In a large academic medical center, patient requests from the community and internal referrals for evaluation of suspected hypermobility conditions were being denied consultation because services specific to this condition not available. We identified gap developed comprehensive unique population. The objective paper is demonstrate solution improving outcomes in neglected population by establishing an innovative outpatient clinic specifically tailored patients with EDS. describe...

10.1007/s42399-022-01218-w article EN cc-by SN Comprehensive Clinical Medicine 2022-07-05

Abstract Background The Ehlers-Danlos Syndromes (EDS) are a group of connective tissue disorders that hereditary in nature and characterized by joint hypermobility fragility. complex this unique patient population requires multidisciplinary care, but appropriate centers for such care do not exist large portions the country. Need more integrated services has been identified Chicagoland, or Chicago its suburbs. In order to explore begin address barriers seeking facing EDS patients region, we...

10.1186/s13023-024-03109-w article EN cc-by Orphanet Journal of Rare Diseases 2024-03-14

To report the prevalence and severity of nonpelvic symptoms for patients with venous-origin chronic pelvic pain (VO-CPP) to describe outcomes after vein stenting embolization.

10.1177/02683555241273109 article EN Phlebology The Journal of Venous Disease 2024-08-10

About 4 out of 10 fibromyalgia patients suffer from depression. The European Alliance Associations for Rheumatology (EULAR) guidelines recommend using antidepressants to treat fibromyalgia.To determine predictors improved outcomes following a multicomponent treatment program.We designed this longitudinal outcome study evaluate the prevalence depression symptoms in diagnosed with at tertiary care facility, and impact on functional after completing program.Tertiary center.This included 411...

10.1177/21501319221120738 article EN cc-by-nc Journal of Primary Care & Community Health 2022-01-01

Pathogenic variants in COL1A1 and COL1A2 are involved osteogenesis imperfecta (OI) and, rarely, Ehlers-Danlos syndrome (EDS) subtypes OI-EDS overlap syndromes (OIEDS1 OIEDS2, respectively). Here we describe a cohort of 34 individuals with likely pathogenic COL1A2, 15 whom have potential OIEDS1 (n = 5) or OIEDS2 10). A predominant OI phenotype frameshift present 4/5 cases OIEDS1. On the other hand, 9/10 EDS phenotype, including four an initial diagnosis hypermobile (hEDS). An additional case...

10.1002/ajmg.c.32038 article EN American Journal of Medical Genetics Part C Seminars in Medical Genetics 2023-03-09

Objectives Comorbidities associated with venous origin chronic pelvic pain (VO-CPP) were evaluated pre and post treatment to assess change. Materials methods 45 women VO-CPP treated stenting and/or embolization. Four surveys assessed symptoms pre- post-treatment: IPPS (chronic pain), PUF (interstitial cystitis), OHQ (dysautonomia), modified ROME III (IBS). Prevalence of joint hypermobility was investigated. Results Ages 18–65. Pretreatment, 64% 49% in the severe range for OHQ, respectively....

10.1177/02683555231219737 article EN Phlebology The Journal of Venous Disease 2023-12-05

The coronavirus disease 2019 (COVID-19) pandemic is taking a massive toll on health care systems globally. We developed the COVID-19 virtual clinic (CVC) in conjunction with drive through testing to cope this situation. There are two arms of CVC: (1) screening arm and (2) positive patient arm. Screening performed over phone based Centers for Disease Control Prevention guideline. Positive patients followed at regular intervals by video appointments where concerns can be addressed provider...

10.1089/tmj.2020.0145 article EN Telemedicine Journal and e-Health 2020-06-09

Background This retrospective study was designed to analyze the prevalence and impact of associated comorbidities on fibromyalgia (FM) outcomes (functionality, pain, depression levels) for patients who participated in an intensive multicomponent clinical program a tertiary care center. Methods Participants included sample 411 diagnosed with FM at large medical center using 2016 ACR criteria. Patients completed 2-day cognitive behavioral treatment (CBT) program, filled out Fibromyalgia Impact...

10.3389/fmed.2023.1301944 article EN cc-by Frontiers in Medicine 2024-01-15

Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was identify novel new or worsening comorbidities self-reported in with LC.

10.3389/fneur.2024.1482917 article EN cc-by Frontiers in Neurology 2024-10-25

Identifying risk factors for post-acute sequelae of COVID-19 (PASC) is important. We conducted a multicenter cross-sectional survey study to define and characterize severe in adults (≥18 years) treated at our virtual clinic from March 1, 2020, through 31, 2021. assessed patient demographics, symptom types, persistence, incidence PASC, COVID-19-caused hospitalizations. Surveyed patients were also asked rate their perception the severity acute symptoms. Continuous variables summarized...

10.1177/10815589231190560 article EN Journal of Investigative Medicine 2023-07-24
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