A5101711606- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Body Contouring and Surgery
- Diabetes Treatment and Management
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Bone Tissue Engineering Materials
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Surgical Simulation and Training
- Orthopaedic implants and arthroplasty
- RNA Interference and Gene Delivery
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Obstructive Sleep Apnea Research
- Minimally Invasive Surgical Techniques
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Dental Implant Techniques and Outcomes
- Gastroesophageal reflux and treatments
- Phagocytosis and Immune Regulation
- Pancreatitis Pathology and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
Third Xiangya Hospital
2015-2024
Central South University
2015-2024
Xiangya Hospital Central South University
2017
South University
2015
Jilin University
2008-2011
Stomatology Hospital
2008
Background and objectives: Chinese type 2 diabetes mellitus (T2DM) patients are characterized by a low body mass index (BMI), significant insulin resistance (IR). The triglyceride glucose (TyG) has not been studied as means of assessing IR in T2DM with BMI < 35 kg/m2. Materials Methods: An open-label cross-sectional study recruited 102 hyper-insulinemic euglycemic clamp, homeostatic model assessment (HOMA-IR), TyG were used to determine the level IR. Based on Pearson’s correlations, disposal...
Background Coronary microvascular dysfunction is common in patients of myocardial infarction with non‐obstructive coronary artery disease. flow reserve (CFR) reflects function and a powerful independent index heart failure. Our previous studies showed that knockout SIRT3 (Sirtuin 3) decreased CFR caused diastolic dysfunction. Few focus on the treatment impaired In present study, we explored role C646, histone acetyltransferase p300 inhibitor, regulating cardiac remodeling (SIRT3KO) mice....
This study aimed to assess the causal relationship between visceral obesity and type 2 diabetes subsequently screen adipose tissue (VAT)-specific targets for diabetes.We examined VAT using bidirectional Mendelian randomisation (MR) followed by multivariable MR. We conducted a transcriptome-wide association (TWAS) leveraging prediction models large-scale genome-wide (74,124 cases 824,006 controls) identify candidate genes in used summary-data-based MR (SMR) co-localisation analysis map genes....
Hydroxyapatite is the main inorganic component of biological bone and tooth enamel, synthetic hydroxyapatite has been widely used as biomaterials. In this study, a facile method developed for fabrication arginine-functionalized europium-doped nanoparticles (Arg-Eu-HAP). The synthesized characterized by transmission electron microscopy, X-ray diffractometry, Fourier transform infrared, Zeta potential analyzer. Its properties with DNA binding, cell toxicity, binding intracellular distribution...
The increased secretion of glucagon-like peptide-1 (GLP-1) after Roux-en-Y gastric bypass (RYGB) is regarded as the main reason for improvement blood glucose. However, single-nucleotide polymorphisms (SNPs) GLP-1 Receptor (GLP1R) impair receptor function, subsequently affecting β cell insulin ultimately efficacy RYGB. In this study, we revealed that two SNPs in GLP1R gene, rs3765467 and rs10305492, could significantly reduce secreted by cells cyclic AMP concentration, whereas promote...
Aims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI of T2DM. We investigated the adipokines and sICAM-1 Chinese subjects T2DM after LRYGB explored relationship postsurgical insulin sensitivity. Methods. Plasma levels adiponectin, sICAM-1, fasting glucose, glycated hemoglobin, serum visfatin were measured before at three months 33 22–30 kg·m −2 ....
T2DM (Type 2 diabetes) is a complex, chronic disease characterized as insulin resistance and islet β-cell dysfunction. Bariatric surgeries such Roux-en-Y gastric bypass (RYGB) surgery laparoscopic sleeve gastrectomy (LSG) have become part of critical treatment regimen in the obesity T2DM. Moreover, GLP-1 increase following bariatric has been regarded significant event surgery-induced remission In this study, high concentration cholesterol-induced lipotoxicity was observed INS-1 cells,...
Background: Insulin resistance (IR) is closely associated with the pathogenesis of type 2 diabetes mellitus (T2DM). However, remission insulin sensitivity after bariatric surgery in patients T2DM and a body mass index (BMI) 27.5-32.5 kg/m2 has not been fully elucidated. Methods: Thirty-six BMI were prospectively consecutively recruited for laparoscopic Roux-en-Y gastric bypass (LRYGB) or sleeve gastrectomy (LSG). Hyperinsulinemic euglycemic clamp, oral glucose tolerance test (OGTT), other...