A5075270486- Bariatric Surgery and Outcomes
- Body Contouring and Surgery
- Diabetes Treatment and Management
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Drug Transport and Resistance Mechanisms
- Gastric Cancer Management and Outcomes
- Lipid metabolism and disorders
- Pharmacology and Obesity Treatment
- Gastroesophageal reflux and treatments
- Obesity and Health Practices
- Anesthesia and Pain Management
- Ion Transport and Channel Regulation
- Abdominal Surgery and Complications
- Boron Compounds in Chemistry
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- Cholesterol and Lipid Metabolism
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
Third Xiangya Hospital
2012-2024
Central South University
2012-2024
Nanjing University of Posts and Telecommunications
2010
Background and objectives: Chinese type 2 diabetes mellitus (T2DM) patients are characterized by a low body mass index (BMI), significant insulin resistance (IR). The triglyceride glucose (TyG) has not been studied as means of assessing IR in T2DM with BMI < 35 kg/m2. Materials Methods: An open-label cross-sectional study recruited 102 hyper-insulinemic euglycemic clamp, homeostatic model assessment (HOMA-IR), TyG were used to determine the level IR. Based on Pearson’s correlations, disposal...
The inhibitor of apoptosis protein survivin has a critical regulatory role in carcinogenesis and treatment tolerance colorectal cancer (CRC). However, the targeted drugs for are extremely limited. In present research, we discovered that Tanshinone IIA (Tan IIA) played dual inhibiting tumorigenesis reversing 5-Fu via modulating expression phosphorylation CRC cells. Mechanistically, Tan suppressed Akt/WEE1/CDK1 signaling pathway, which led to downregulation Thr34 destruction interaction...
Background: Obesity is a widely recognized global public health issue, and bariatric surgery has emerged as an effective intervention for alleviating obesity associated complications. However, the impact of on male reproductive function remains inconclusive in literature. The current understanding laparoscopic sleeve gastrectomy ambiguous, despite its status most commonly performed surgery. This prospective cohort study aimed to investigate erectile semen quality. Patients Methods: A total...
Abstract Type II diabetes is a complex, chronic, and progressive disease. Glucagon‐like peptide‐1 (7–36) amide (GLP‐1) gut hormone released from the L cells which stimulate insulin secretion promotes gene expression β‐cell growth differentiation. Elevated levels of hormones secreted by are an essential reason for improvement. GLP‐1 has been reported to be regulated farnesoid X receptor (FXR), transcriptional sensor bile acids also acts on glucose metabolism. Herein, we attempted evaluate...
T2DM (Type 2 diabetes) is a complex, chronic disease characterized as insulin resistance and islet β-cell dysfunction. Bariatric surgeries such Roux-en-Y gastric bypass (RYGB) surgery laparoscopic sleeve gastrectomy (LSG) have become part of critical treatment regimen in the obesity T2DM. Moreover, GLP-1 increase following bariatric has been regarded significant event surgery-induced remission In this study, high concentration cholesterol-induced lipotoxicity was observed INS-1 cells,...
Obesity is related to many pathophysiological changes that may result in altered drug disposition. Omeprazole the most common option utilized for acid-related disorders ; however, pharmacokinetic (PK) and dosing recommendations obese patient population are lacking.Data from 40 healthy subjects with normal weights data 61 were included. The all received a single dose of 20 mg omeprazole. Nonlinear mixed effects modeling performed characterize effect obesity on omeprazole PK.A one-compartment...
Type II diabetes is a complex, chronic, and progressive disease. Glucagon-like peptide-1 (7-6) amide (GLP-1) gut hormone released from the L cells which stimulates insulin secretion, promotes gene expression β-cell growth differentiation. Elevated levels of secreted by are an important reason for improvement. GLP-1 secretion has been reported to be regulated farnesoid X receptor (FXR), transcriptional sensor bile acids also acts on glucose metabolism. Herein, we attempted evaluate effect FXR...
Omeprazole is commonly prescribed to obese patients and after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole LSG are still unknown. Therefore, the aim this study was investigate in before LSG. A total 331 blood samples were collected from 62 preoperatively (visit 1) followed by 41 7 days post-LSG 2) 20 1 month 3). Population pharmacokinetic analysis performed using NONMEM characterize effect on absorption disposition. one-compartment model with 12 transit...