A5103169116- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- ECG Monitoring and Analysis
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Health and Wellbeing Research
- Advanced MRI Techniques and Applications
- Biochemical effects in animals
- Dermatological and COVID-19 studies
- Neonatal Respiratory Health Research
- Parvovirus B19 Infection Studies
- Neuroscience of respiration and sleep
- Thermoregulation and physiological responses
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Renal and Vascular Pathologies
- Blood groups and transfusion
- Stress Responses and Cortisol
- Prenatal Screening and Diagnostics
- Menstrual Health and Disorders
Ospedale dei Bambini Vittore Buzzi
2011-2025
University of Milan
2011-2017
Phase rectified signal averaging (PRSA) is a new method of fetal heart rate variability (fHRV) analysis that quantifies the average acceleration (AC) and deceleration capacity (DC) heart. The aim this study was to evaluate AC DC fHR [recorded by trans-abdominal electrocardiogram (ta-fECG)] in relation Doppler velocimetry characteristics intrauterine growth restriction (IUGR).Prospective case-control study.Single third referral centre.IUGR (n = 66) between 25 40 gestational weeks...
Background Fetal heart rate (FHR) variability is an indirect index of fetal autonomic nervous system (ANS) integrity. FHR analysis in labor fails to detect early hypoxia and acidemia. Phase-rectified signal averaging (PRSA) a new method complex biological signals that more resistant non-stationarities, loss artifacts. It quantifies the average cardiac acceleration deceleration (AC/DC) capacity. Objective The aims study were: (1) investigate AC/DC ovine fetuses exposed acute hypoxic-acidemic...
Objective: To compare intra-partum performance of trans-abdominal electrocardiogram with Doppler telemetry. Methods: In this prospective longitudinal study, simultaneous monitoring ECG and telemetry was performed in 41 uncomplicated term singleton pregnancies during labour. Results: The overall success rate for FHR similar between (88.5 ± 16.7% vs 89.4 7.6%), except the second stage A significantly higher confusion (p < 0.001) fetal maternal heart found (4.5 4.5%) compared (1.3 1.9%),...
Fetal monitoring during labour currently fails to accurately detect acidemia. We developed a method assess the multidimensional properties of fetal heart rate variability (fHRV) from trans-abdominal electrocardiogram (fECG) labour. aimed this novel bioinformatics approach for correlation between fHRV and neonatal pH or base excess (BE) at birth.
Fetal heart rate (FHR) sampling used on the bedside is equal or less than 4 Hz. Current FHR analysis methods fail to detect incipient fetal acidemia. In a sheep model of human labour we showed that rates near 1000 Hz are needed Trans-abdominal ECG (t-a fECG) at 900 combined with complex signals bioinformatics approach promise in cohort. Here validate this finding retrospective cohort study by comparing performance same predict pH and BE birth cohorts sampled either
Introduction: Current classification of hypertensive disorders pregnancy (HDP) is mostly based on temporal differentiating HDP according to early and late onset the disease. However, epidemiological clinical data suggest that there are two different phenotypes coexist at any gestational age: associated intrauterine growth restriction (HDP-IUGR) appropriate for age fetal (HDP-AGAf). The aim study was evaluate association first trimester uterine arteries (UtA) by Doppler velocimetry, maternal...
Couplings between uterine contractions (UC) and fetal heart rate (fHR) provide important information on condition during labor. At present, couplings UC fHR are assessed by visual analysis interpretation of cardiotocography. The application computerized approaches is restricted due to the non-stationarity signal, missing data noise, typical for fHR. Herein, we propose a novel approach assess fHR, based signal-processing algorithm termed bivariate phase-rectified signal averaging (BPRSA)....
Trophoblastic invasion and placental growth are critical for pregnancy outcome. The volume can be assessed by 3 D ultrasound using Virtual Organ Computer-aided Analysis (VOCAL). Epidemiological clinical data suggest that there two different phenotypes of hypertensive disorders (HDP) coexist at any gestational age: HDP associated to fetal impairment appropriate age growth. aim this study was determine whether in the first trimester differs between women with or not uncomplicated...
Methods: 10733 women with a complete first trimester screening were included.Potential predictors for birth weight included maternal age, BMI, parity, smoking status, type of conception, time difference (days) between date pregnancy based on CRL and LMP (CRL-LMP), uterine artery lowest PI (UtA-LPI), PAPP-A bHCG (MoM) as well abdominal circumference (AC, Z-score).Bootstrap methods used model selection estimation, under an approximately uniform distribution weight.A was built to predict...
AbstractAbstractAims: To investigate maternal hemodynamic status in pregnancies complicated by HDP and/or IUGR and severe without HDP.Methods: In this prospective study we enrolled pregnant women between 24 38 weeks divided in: with appropriate for gestational age fetuses (HDP-AGA), associated (HDPIUGR), a group of controls matched age. Severe was defined as abdominal circumference <5th centile Doppler velocimetry umbilical artery42SD. Diagnosis made according to the criteria ISSHP. A...
Labor exposes the fetus to repetitive transient hypoxic stress.We assessed whether such events modify regularity of fetal inter-beat interval series (fRR), using an in-vivo near-term sheep model, by means entropy measures.Umbilical cord occlusions (UCO), from partial complete, were applied 7 pregnant sheep.Fetal blood samples collected at intervals 20 minutes, quantify pH, lactate and base deficit ("biomarkers").Fetal ECG recordings with implanted electrodes used derive fRR series.Sample...
The aim of the study was to evaluate correlation between placental volume and uterine artery (UtA) Doppler velocimetry in 1st trimester pregnancy. This offered women with singleton pregnancy at their 11–14 weeks US screening. Ninety five agreed participate signed informed consent. CRL measured UtA mean P.I. (mPI) calculated. In addition, 3D volumes placenta were acquired (Voluson E8, GE). off-line analysis performed by 4D View software calculated using VOCAL option (15°) same operator...
The objective of our study is to investigate maternal hemodynamic status in pregnancies complicated by HDP associated or not with IUGR and a group severe without characterised high grade placental insufficiency. This part prospective women referred High Risk Pregnancy Unit at Buzzi Children's Hospital. We enrolled singleton between 24 38 weeks gestation divided 4 groups: appropriate for gestational age fetuses (HDP-AGAf), (HDP-IUGR), Controls matched age. Severe was defined as an abdominal...
Aims: To compare maternal hemodynamic profile during pregnancy and at 6–12 months after delivery in pregnancies with different HDP phenotypes or severe IUGR.Methods: We enrolled patients between 24 38 weeks of gestation: appropriate for gestational age foetuses (HDP-AGAf), IUGR (HDP-IUGR), Controls matched age. Severe was defined as abdominal circumference <5th centile a PI umbilical artery42SD. Diagnosis made according to the criteria ISSHP. Maternal echocardiography performed each group...
Objective: To explore maternal cardiac deceleration capacity (DC), a marker of autonomic function derived from heart rate variability analysis, in pregnancies complicated by intrauterine growth restriction (IUGR) and hypertensive disorders pregnancy (HDP) associated to IUGR (HDP-IUGR) or appropriate for gestational age fetuses (HDP-AGAf).Methods: Single-center case-control study conducted at Buzzi Children’s Hospital, Milan. Maternal electrocardiograms were analyzed Phase-Rectified Signal...