Lin‐Chen Huang

ORCID: 0000-0001-6214-020X
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About
Contact & Profiles
Research Areas
  • Metallic Glasses and Amorphous Alloys
  • Photosynthetic Processes and Mechanisms
  • Magnetic properties of thin films
  • Magnetic Properties of Alloys
  • HIV Research and Treatment
  • Plant Gene Expression Analysis
  • Plant Molecular Biology Research
  • Immune Cell Function and Interaction
  • interferon and immune responses
  • Polyamine Metabolism and Applications
  • Viral-associated cancers and disorders
  • Mosquito-borne diseases and control
  • CRISPR and Genetic Engineering
  • Lymphoma Diagnosis and Treatment

National Taiwan University
2020-2024

Washington University in St. Louis
2024

National Chung Hsing University
2019-2020

ABSTRACT A critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms conical core when it rearranges around dimeric RNA genome and associated viral proteins. Although mutations in CA have been reported to alter innate immune sensing of HIV-1, a direct link between stability nucleic acids has not established. Herein, we assessed how manipulating lattice through chemical genetic approaches affects recognition HIV-1. We found that destabilization resulted potent...

10.1128/mbio.00348-24 article EN cc-by mBio 2024-03-26

Abstract Light triggers an enhancement of global translation during photomorphogenesis in Arabidopsis, but little is known about the underlying mechanisms. The phosphorylation α-subunit eukaryotic initiation factor 2 (eIF2α) at a conserved serine residue N-terminus has been shown as important mechanism for regulation protein synthesis mammalian and yeast cells. However, whether this plant eIF2α plays role remains elusive. Here, we show that quadruple mutant SUPPRESSOR OF PHYA-105 family...

10.1038/s41467-024-47848-7 article EN cc-by Nature Communications 2024-04-24

Abstract ETHYLENE RESPONSE FACTOR 1 (ERF1) plays an important role in integrating hormone crosstalk and stress responses. Previous studies have shown that ERF1 is unstable the dark its degradation mediated by UBIQUITIN‐CONJUGATING ENZYME 18. However, whether there are other enzymes regulating ERF1's stability remains unclear. Here, we use various vitro vivo biochemical, genetic stress‐tolerance tests to demonstrate both CONSTITUTIVE PHOTOMORPHOGENIC (COP1) SUMO‐CONJUGATING (SCE1) regulate of...

10.1111/pce.14850 article EN Plant Cell & Environment 2024-02-11

The FePt film above 10 nm critical lattice relaxation thickness was prepared and the ultrathin MgTiTaON layer interleaved in between multilayer stack is FePt(6 nm)/[MgTiTaON(1 nm)/FePt(4 nm)]2. Next, films were co-sputtered with (Ag, C) segregants during deposition stacks nm)(Ag, C)(x vol %)/[MgTiTaON (1 (x %)]2 = 0, 10, 20, 30, 40). After high temperature at 470 °C, granular FePt(Ag, C, MgTiTaON) illustrated perpendicular magnetization out-of-plane coercivity (Hc) increased highest Hc 18.3...

10.3390/coatings9040238 article EN Coatings 2019-04-08
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