- Metallic Glasses and Amorphous Alloys
- Photosynthetic Processes and Mechanisms
- Magnetic properties of thin films
- Magnetic Properties of Alloys
- HIV Research and Treatment
- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Immune Cell Function and Interaction
- interferon and immune responses
- Polyamine Metabolism and Applications
- Viral-associated cancers and disorders
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
National Taiwan University
2020-2024
Washington University in St. Louis
2024
National Chung Hsing University
2019-2020
ABSTRACT A critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms conical core when it rearranges around dimeric RNA genome and associated viral proteins. Although mutations in CA have been reported to alter innate immune sensing of HIV-1, a direct link between stability nucleic acids has not established. Herein, we assessed how manipulating lattice through chemical genetic approaches affects recognition HIV-1. We found that destabilization resulted potent...
Abstract Light triggers an enhancement of global translation during photomorphogenesis in Arabidopsis, but little is known about the underlying mechanisms. The phosphorylation α-subunit eukaryotic initiation factor 2 (eIF2α) at a conserved serine residue N-terminus has been shown as important mechanism for regulation protein synthesis mammalian and yeast cells. However, whether this plant eIF2α plays role remains elusive. Here, we show that quadruple mutant SUPPRESSOR OF PHYA-105 family...
Abstract ETHYLENE RESPONSE FACTOR 1 (ERF1) plays an important role in integrating hormone crosstalk and stress responses. Previous studies have shown that ERF1 is unstable the dark its degradation mediated by UBIQUITIN‐CONJUGATING ENZYME 18. However, whether there are other enzymes regulating ERF1's stability remains unclear. Here, we use various vitro vivo biochemical, genetic stress‐tolerance tests to demonstrate both CONSTITUTIVE PHOTOMORPHOGENIC (COP1) SUMO‐CONJUGATING (SCE1) regulate of...
The FePt film above 10 nm critical lattice relaxation thickness was prepared and the ultrathin MgTiTaON layer interleaved in between multilayer stack is FePt(6 nm)/[MgTiTaON(1 nm)/FePt(4 nm)]2. Next, films were co-sputtered with (Ag, C) segregants during deposition stacks nm)(Ag, C)(x vol %)/[MgTiTaON (1 (x %)]2 = 0, 10, 20, 30, 40). After high temperature at 470 °C, granular FePt(Ag, C, MgTiTaON) illustrated perpendicular magnetization out-of-plane coercivity (Hc) increased highest Hc 18.3...