A5070143546- HIV Research and Treatment
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- interferon and immune responses
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
Shenzhen Bay Laboratory
2024
Washington University in St. Louis
2021-2024
HIV-1 has high mutation rates and exists as mutant swarms within the host. Rapid evolution of allows virus to outpace host immune system, leading viral persistence. Approaches targeting immutable components are needed clear infection. Here, we report that caspase recruitment domain-containing protein 8 (CARD8) inflammasome senses protease activity. can evade CARD8 sensing because its remains inactive in infected cells before budding. Premature intracellular activation triggered...
While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-infected macaques, the mechanisms underlying this remain incompletely understood, most death involving uninfected cells. In contrast, SIV infection of "natural" hosts such as sooty mangabeys does not cause AIDS despite high-level viremia. Here, we report that CARD8 inflammasome activated immediately after entry by viral protease encapsulated incoming virions. Sensing activity leads rapid pyroptosis...
ABSTRACT A critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms conical core when it rearranges around dimeric RNA genome and associated viral proteins. Although mutations in CA have been reported to alter innate immune sensing of HIV-1, a direct link between stability nucleic acids has not established. Herein, we assessed how manipulating lattice through chemical genetic approaches affects recognition HIV-1. We found that destabilization resulted potent...
Abstract The 4-Vinylcyclohexene dioxide (VCD) is a common occupational chemical which can lead to ovary toxicity. Autophagy an evolutionarily conserved process that crucial for regulating the follicular development during whole reproductive lifespan. In order study effect and mechanism of VCD on autophagy in ovary, was intraperitoneally injected into mouse induce toxicity model. results showed inhibited IGF1R/AKT/mTOR signaling pathway by down-regulating expression IGF1R ovarian granulosa...