A5046606029- Hepatitis C virus research
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Animal Disease Management and Epidemiology
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- Molecular Biology Techniques and Applications
- Plant Virus Research Studies
- Malaria Research and Control
- Insect symbiosis and bacterial influences
Rega Institute for Medical Research
2020-2023
KU Leuven
2020-2023
As viral genomic imprints in host genomes, endogenous elements (EVEs) shed light on the deep evolutionary history of viruses, ancestral ranges, and ancient viral-host interactions. In addition, they may provide crucial information for calibrating timescales. this study, we conducted a comprehensive silico screening large data set available mammalian genomes EVEs deriving from members family Flaviviridae, an important group viruses including well-known human pathogens, such as Zika, dengue,...
Here, we identified a novel class of compounds which demonstrated good antiviral activity against dengue and Zika virus infection. These derivatives constitute intermediates in the synthesis indole (ervatamine-silicine) alkaloids share tetracyclic structure, with an piperidine fused to seven-membered carbocyclic ring. Structure-activity relationship studies indicated importance substituent at position C-6 especially presence benzyl ester for cytotoxicity molecules. In addition,...
In the search for natural reservoirs of hepatitis C virus (HCV), a broad diversity non-human viruses within Hepacivirus genus has been uncovered. However, evolutionary dynamics that shaped and timescale hepaciviruses evolution remain elusive. To gain further insights into origins this genus, we screened large dataset wild mammal samples (n = 1,672) from Africa Asia, generated 34 full-length hepacivirus genomes. Phylogenetic analysis these data together with publicly available genomes...
Abstract Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, zoonotic origins HCV still remain unresolved. Motivated by recent findings divergent in rodents and plausible African origin genotypes, we have screened large collection small mammals samples from seven sub-Saharan countries. Out 4,303 screened, eighty were...
This protocol is used for successful NGS library preparation from total RNA of animal tissue samples. With this method we obtained full-length paramyxovirus genomes using the Illumina sequencing platform. It works most efficiently on viruses possessing a polyA tail, but it can also be any other viral sequences originating
Abstract As viral genomic imprints in host genomes, endogenous elements (EVEs) shed light on the deep evolutionary history of viruses, ancestral ranges, and ancient viral-host interactions. In addition, they may provide crucial information for calibrating timescales. this study, we conducted a comprehensive silico screening large dataset available mammalian genomes EVEs deriving from members family Flaviviridae , an important group viruses including well-known human pathogens. We identified...
Abstract Hepatitis C virus (HCV; genus Hepacivirus ) represents a major public health problem, infecting about 3 % of the human population ( ± 185,000,000 people). Because no plausible animal reservoir carrying closely related hepaciviruses has been identified, zoonotic origins HCV still remain elusive. Motivated by recent findings divergent in rodents and African origin genotypes, we have screened comprehensive collection small mammals samples from seven sub-Saharan countries. Out 4,303...