- Pharmacological Effects and Toxicity Studies
- Video Surveillance and Tracking Methods
- Aortic aneurysm repair treatments
- Epilepsy research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Electroconvulsive Therapy Studies
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Treatment of Major Depression
- Aortic Disease and Treatment Approaches
- Parkinson's Disease and Spinal Disorders
- Schizophrenia research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Neuropeptides and Animal Physiology
- Acute Ischemic Stroke Management
- Vascular Procedures and Complications
- Advanced Vision and Imaging
- Neurological and metabolic disorders
- Cardiovascular Syncope and Autonomic Disorders
- Neurotransmitter Receptor Influence on Behavior
- Drug-Induced Ocular Toxicity
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Hormonal Regulation and Hypertension
- Viral gastroenteritis research and epidemiology
Ninewells Hospital
2021-2024
University of Canterbury
2008-2023
Los Angeles Medical Center
1973-2023
Kaiser Permanente
2015-2023
NHS Tayside
2023
Wye Valley NHS Trust
2021
University College Cork
2019
Columbia University Irving Medical Center
2007-2018
NewYork–Presbyterian Hospital
2018
Edinburgh Royal Infirmary
2014-2017
Abstract Background: The use of carotid artery stenting with embolic protection has been practiced for over a decade in the United States, and increasingly so since received FDA approval 2004. While there have attempts at establishing predictors outcomes stenting, they generally limited to single center experiences and/or multicenter retrospective surveys. This report examines earliest largest prospective neurologist‐adjudicated experience States post device approval. Methods: C arotid A...
Abstract Background: Pivotal study data examining carotid stenting with embolic protection as a less invasive alternative to endarterectomy for high surgical risk patients have been acquired under controlled conditions highly selected physicians and hospitals. This report examines outcomes of post‐approval after diffusion this technology broader cross‐section Methods: The Carotid Acculink/Accunet Post‐Approval Trial Uncover Unanticipated or Rare Events (CAPTURE) is prospective, multi‐center...
Older depressed patients treated with imipramine or amitriptyline developed higher steady-state plasma levels of imipramine, desipramine, and amitriptyline. In imipramine-treated this finding was associated a decreased rate drug elimination from plasma. These findings provide at least partial explanation for the increased susceptibility older patient to tricyclic antidepressant side effects also pharmacological rationale use lower dosages in age group.
Although previous reports of carotid stenting with embolic protection (CAS) have focused on clinical outcomes death, stroke and myocardial infarction, there are few data available characterizing the strokes that occur during CAS, thus limiting understanding potential mechanisms. This report examines timing, location, severity, type occurring CAS in Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Unanticipated or Rare Events (CAPTURE) study.The CAPTURE is a prospective, multicenter...
The anti-androgen cyproterone acetate (CA) causes regression of the seminal vesicle when administered to mature male rat, and CA treatment pregnant rat permits vaginal development in offspring. CA, however, does not inhibit androgen controlled sexual behavior rats. It was therefore hypothesized that might uptake retention l,2-3H-testosterone peripheral genital tissues, but central neural tissues which mediate mating behavior. To test this hypothesis, castrate males were tritiated...
Urinary excretion of normetanephrine, the metabolite norepinephrine which may reflect noradrenergic activity, showed a gradual increase during period definitive clinical improvement in depressed patients treated with imipramine. These and other findings study suggest that activity gradually from depression, be relatively decreased retarded depression increased mania. The pharmacological action imipramine initiate increases improvement, patients, are subsequently maintained after discontinuation drug.
Since the initial observations of a relationship between depression and an increase in urinary adrenal glucocorticoids psychiatric patients by Reiss (1953) Rizzo et al. (1954), there have been number studies confirming this using various chemical techniques (Board , 1957; Bunney 1964 1965; Gibbons, Maxwell Wilcox, 1960; Gibbons McHugh, 1962; 1964; Kurland, 1964a 1964b; Pryce 1964). One questions that immediately comes to mind reviewing work has do with specificity relationship. Perhaps rise...
The Kinect sensor was originally designed for use as a controller video games, however the noise and latency in output of its skeleton tracking system negatively impact user experience. This paper compares four different filter-based approaches to mitigating that simple game: SDK's built-in Holt double exponential smoothing filter, an averaging Kalman filter with constant-value model, Wiener Process Acceleration (WPA) model. both have good performance but introduce relatively large amounts...
Abstract BACKGROUND New therapies are especially needed for uMGMT nGBM. NRG Oncology BN002 (phase I) demonstrated safety and preliminary efficacy of Ipi+Nivo nGBM, leading to BN007 as phase II/III. METHODS Adults with nGBM (WHO 2016) KPS ≥ 70 were randomized RT concurrent adjuvant or TMZ, stratified by glioma-recursive partitioning analysis class (RPA), intent use tumor-treating fields (NCT04396860). Phase II primary endpoint was progression-free survival (PFS), powered 95% detect a hazard...
(1973). Group Therapy with Feminine Boys and Their Parents. International Journal of Psychotherapy: Vol. 23, No. 1, pp. 54-68.