The Footscan® platform system is one of the most commonly used clinical tools for measurement foot pressure. present study was designed to assess repeatability and identify range loading parameters observed in normal foot.Measurements were collected from 32 healthy participants, 15 females 17 males, twice at an interval 1 week. Peak pressure (PP), contact time (CT), area (CA), pressure-time integral (PTI), maximum force (MaF) recorded; these investigated 10 areas foot: medial heel, lateral...

The purpose of this study was to investigate the therapeutic effects crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), 17β-estradiol (E 2, 25 μg/kg/day), graded doses (5, 10, or 20 mg/kg/day). Daily oral administration E 2 started 4 weeks after lasted for 16 weeks. Our results showed dose-dependently inhibited BMD reduction L4 vertebrae...

There have been numerous studies conducted to investigate the pullout force of pedicle screws in bone with different material properties. However, fewer investigated region effect (RoE), stress distribution and contour pattern cancellous surrounding screw. Screw experiments were performed from two foams corresponding reaction was documented for validation a computational screw-foam model based on finite element (FE) methods. After validation, simulations screw-bone models, properties three...

The aim of this study was to investigate the protective effect cordymin on diabetic osteopenia in alloxan-induced rats and possible mechanisms involved. received daily intraperitoneal injection with (20, 50, 100 mg/kg/day) for 5 weeks. Cordymin could restore circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid (TRAP), insulin levels a dose-dependent manner. Also, treatment partially reverse β cells death decrease total...

The mechanical response of the spinal cord during burst fracture was seldom quantitatively addressed and only few studies look into internal strain white grey matters within thoracolumbar (TLBF). aim study is to investigate TLBF correlate percent canal compromise (PCC) with in cord.A three-dimensional (3D) finite element (FE) model human T12-L1 visco-elastic property generated based on transverse sections images cord, validated against published literatures under static uniaxial tension...

The Footscan platform is a useful tool for plantar pressure measurement. However, there still controversy over whether or not the should be covered by top-layer during test. This study was designed to compare reliability of and identify differences foot loading parameters between without (WOT) with (WT) protocols. Measurements were taken from thirty-two healthy subjects. Participants tested using WOT WT Three trials performed two separate testing sessions 7-day interval. Peak pressure,...

As cortical bone has a hierarchical structure, the macroscopic strength may be affected by alterations of mineral crystal and collagen, which are main components bone. Limited studies focused on time related these two in osteoporosis, their contributions to mechanics at tissue level whole-bone level. Therefore, purpose this study was elucidate changes collagen ovariectomized (OVX) rabbits, relate nanomechanics macromechanics. 40 Rabbits (7-month-old) were randomly allocated into groups (OVX...

Angiotensin-converting enzyme inhibitors are widely prescribed to regulate blood pressure. High doses of orally administered perindopril have previously been shown improve fracture healing in a mouse femur model. In this study, was directly the area with goal stimulating repair. Three months after being ovariectomized (OVX), tibial fractures were produced Sprague-Dawley rats and subsequently stabilized intramedullary wires. Perindopril (0.4 mg/kg/day) injected locally at fractured site for...

IIn nt tr ro od du uc ct ti io on n: : The movements of the cervical spine during head rotation are too complicated to measure using conventional radiography or computed tomography (CT) techniques.In this study, we three-dimensional segmental motion in vivo a non-invasive measurement technique.M Ma at te er ri ia al l an nd d m me et th ho ds s: Sixteen healthy volunteers underwent CT rotation.Occiput (Oc) -T1 reconstructions were created each 3 positions: supine and maximum left right...

This study was aimed at elucidating the temporal changes of microarchitectural and mechanical parameters cancellous bone in osteoporotic rabbit model induced by ovariectomy (OVX) combined with glucocorticoid (GC) administration. Osteoporotic (OP) group received bilateral OVX injections GC, while sham only operation. Cancellous quality vertebrae femoral condyles each assessed DXA, μ CT, nanoindentation, biomechanical tests pre-OVX 4, 6, 8 weeks after injection. With regard to condyles,...

A finite element analysis of the screw pullout procedure for osteoporotic cancellous bone using screw-bone unit model without cortical layer.The objective is to determine region effect (RoE) during and predict proper amount injection cement (AIC) in augmentation.For spine, AIC a critical factor augmentation performance leakage risk. There are few studies on literature.Three models were established, 2 screw-foam used validation study, 1 was investigation RoE AIC. The simulations conducted....

A deep learning-based model for automatic diagnosis and classification of adolescent idiopathic scoliosis has been constructed. This mainly included key points detection Cobb angle measurement. 748 full-length standing spinal X-ray images were retrospectively collected, which 602 used to train validate the model, 146 test performance. The results showed that had good diagnostic performance, with an accuracy 94.5%. Compared experts' measurement, 94.9% its measurement within clinically...

Abstract Recent trends have led to an interest in Ponseti treatment for correcting neglected congenital clubfoot. Although good clinical and functional outcomes been reported, the plantar pressure distribution after of clubfoot has not explored yet. The present study aimed investigate whether pressures normalized following patients with Pedobarographic, clinical, examinations were performed 22 children (aged, 91.0 ± 40.3 months) unilateral clubfeet, treated using method at 27.8 12.1 months...

Recent clinical studies indicated that angiotensin receptor blockers (ARBs) would decrease the risk of bone fractures in elderly populations. There is little known about role ARBs process fracture healing. The purpose present study was to verify hypothesis systemic treatment with telmisartan has ability promote In this study, femur were produced 96 mature male BALB/c mice. Animals treated or vehicle. Fracture healing analysed after 2, 5 and 10 weeks postoperatively using X-ray, biomechanical...

Successful clinical and radiographic outcomes have been reported in patients with unilateral developmental dysplasia of the hip (DDH) following Pemberton pericapsular osteotomy (PPO). However, residual gait deviations are seen both affected unaffected limbs. To date it is not known whether these result abnormal plantar pressure such patients. This study investigated this possibility by performing pedobarographic, clinical, examinations after PPO 20 (age: 102.5 ± 19.0 months) DDH who...