A5082767586- Neurobiology and Insect Physiology Research
- Cancer, Hypoxia, and Metabolism
- Animal Behavior and Reproduction
- Physiological and biochemical adaptations
- Signaling Pathways in Disease
- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Pregnancy-related medical research
- Mitochondrial Function and Pathology
- Hippo pathway signaling and YAP/TAZ
- Circadian rhythm and melatonin
- Plant and fungal interactions
- Invertebrate Immune Response Mechanisms
- Cellular transport and secretion
- Tendon Structure and Treatment
- Porphyrin Metabolism and Disorders
- Heat shock proteins research
- Erythrocyte Function and Pathophysiology
- Nuclear Structure and Function
- HIV/AIDS drug development and treatment
- Immune cells in cancer
- Biochemical and Molecular Research
- Developmental Biology and Gene Regulation
- Neuroendocrine regulation and behavior
- Insect and Arachnid Ecology and Behavior
Inserm
2013-2024
Centre National de la Recherche Scientifique
2013-2024
Institut Sophia Agrobiotech
2020-2024
Northeastern University
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Université Côte d'Azur
2015-2021
Institut de Biologie Valrose
2013-2020
University of the Philippines Manila
2018
Fundación Instituto Leloir
2007-2017
University of Buenos Aires
1997-2010
Highlights•The relaxin family receptor Lgr3 controls Dilp8-induced developmental delay•A single pair of bilateral Lgr3-positive (GCL) neurons mediates Dilp8 function•GCL physically interact with PTTH neurons•Lgr3 signaling in GCL coordinates growth and limits variabilitySummaryEarly transplantation grafting experiments suggest that body organs follow autonomous programs [1–3], therefore pointing to a need for coordination mechanisms produce fit individuals proper proportions. We recently...
Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show the prothoracicotropic hormone (PTTH), a neuropeptide controls developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two sensors--the Bolwig's organ and peripheral class IV dendritic arborization neurons--to regulate avoidance. We found PTTH concomitantly promotes...
Adult size and fitness are controlled by a combination of genetics environmental cues. In Drosophila, growth is confined to the larval phase final body impacted duration this phase, which under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed play central role in controlling length through regulation ecdysone production, steroid that initiates molting metamorphosis. Here, we test examining consequences null mutations Ptth gene for Drosophila...
Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription that induce wide range genes in response to low oxygen tension. Molecular mechanisms mediate oxygen-dependent HIF regulation operate at the level alpha subunit, controlling protein stability, subcellular localization, and transcriptional coactivator recruitment. We have conducted an unbiased genome-wide RNA interference (RNAi) screen Drosophila cells aimed identification required...
The <i>Drosophila</i> adult male terminalia originate from the genital disc. During pupal stages, external parts of evert two ventral stalks; everted left and right dorsal halves fuse at midline. At same time perform a 360 clockwise rotation. Several mutations are known to affect rotation terminalia, while none is closure. We show here that <i>Pvf1</i> gene, encoding one three homologues mammalian VEGF/PDGF growth factors, required for both processes. Males either mutant or bearing dominant...
Autophagy is an evolutionary conserved process by which eukaryotic cells undergo self-digestion of cytoplasmic components. Here we report that a novel Drosophila immunophilin, have named Zonda, critically required for starvation-induced autophagy. We show Zonda operates at early stages the process, specifically Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition. displays even distribution under basal conditions and, soon after starvation, nucleates in endoplasmic...
Hypoxia-inducible factor alpha (HIF-alpha) proteins are regulated by oxygen levels through several different mechanisms that include protein stability, transcriptional coactivator recruitment, and subcellular localization. It was previously reported these transcription factors mainly nuclear in hypoxia cytoplasmic normoxia, but so far the molecular basis of this regulation is unclear. We show here Drosophila melanogaster HIF-alpha Sima shuttles continuously between nucleus cytoplasm....
The Drosophila HIFalpha homologue, Sima, is localized mainly in the cytoplasm normoxia and accumulates nucleus upon hypoxic exposure. We have characterized mechanism governing Sima oxygen-dependent subcellular localization found that shuttles continuously between cytoplasm. previously shown nuclear import depends on an atypical bipartite signal mapping next to C-terminus of protein. show here export mediated part by a CRM1-dependent degradation domain (ODDD). requires both hydroxylation...
Exocytosis is a fundamental process in physiology, that ensures communication between cells, organs and even organisms. Hormones, neuropeptides antibodies, among other cargoes are packed exocytic vesicles need to reach fuse with the plasma membrane release their content extracellular milieu. Hundreds of proteins participate this several others its regulation. We report here novel component machinery, Drosophila transmembrane immunophilin Zonda (Zda), previously found autophagy. Zda highly...
In meristem cultures of Baccharis coridifolia, a white slow-growing sterile fungus frequently grows from tissues to cover the explants. Histological studies indicate that this is epibiotic on meristems and in axils leaf primordia. Through comparison 18S rDNA sequence epibiont those available previously published studies, we were able determine member Hypocreales. Colonies epibiont, grown PDA, MEA V8, compared with biotrophic fungi Clavicipitaceae (Hypocreales).
Larvicidal and Adult Mosquito Attractant Activity of Auricularia auricula-judae Mushroom Extract on Aedes aegypti (L.) Culex sitiens WiedemannTanawat Chaiphongpachara, Kantima Sumchung, Kitthisak Khlaeo Chansukh
Abstract Hypoxia-HIF-1α-driven immunosuppressive transcription and cAMP-elevating signaling through A2A-adenosine receptors (A2AR) represent a major tumor-protecting pathway that enables immune evasion. Recent promising clinical outcomes due to the blockade of adenosine-generating enzyme CD73 A2AR in patient’s refractory all other therapies have confirmed importance targeting hypoxia-adenosinergic signaling. We report novel feasible approach target upstream stage immunosuppression using an...
Steroid hormones, crucial for development and physiology, were traditionally believed to diffuse passively through membranes. However, recent evidence shows insect steroid ecdysone being secreted via regulated exocytosis, but the mechanisms ensuring successful hormone release into circulation remain unclear. Our study identifies specialized membrane protrusions, filopodia-like structures named "hormonemes," in Drosophila prothoracic gland as essential vesicle release. Confocal imaging...
In meristem cultures of Baccharis coridifolia, a white slow-growing sterile fungus frequently grows from tissues to cover the explants. Histological studies indicate that this is epibiotic on meristems and in axils leaf primordia. Through comparison 18S rDNA sequence epibiont those available previously published studies, we were able determine member Hypocreales. Colonies epibiont, grown PDA, MEA V8, compared with biotrophic fungi Clavicipitaceae (Hypocreales).
ABSTRACT Exocytosis is a fundamental process in physiology, communication between cells, organs and even organisms. Hormones, neuropeptides antibodies, among other cargoes are packed exocytic vesicles that need to reach fuse with the plasma membrane release their content extracellular milieu. Hundreds of proteins participate this several others its regulation. We report here novel component machinery, Drosophila transmembrane immunophilin Zonda (Zda), previously found autophagy. Zda highly...