A5034652078- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Allergic Rhinitis and Sensitization
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Complementary and Alternative Medicine Studies
- Trace Elements in Health
- Research on Leishmaniasis Studies
- Genomic variations and chromosomal abnormalities
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Neurological Disorders and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Leptospirosis research and findings
- Lymphatic System and Diseases
- Diagnosis and treatment of tuberculosis
- Education, Psychology, and Social Research
- Amoebic Infections and Treatments
- Alcoholism and Thiamine Deficiency
- Pancreatitis Pathology and Treatment
- Acne and Rosacea Treatments and Effects
Charles University
2012-2024
University of South Bohemia in České Budějovice
2023
Masaryk University
2019
Fakultní nemocnice Bulovka
2012-2015
State Research Center for Dermatovenereology and Cosmetology
2013
University Hospital Olomouc
1967
Palacký University Olomouc
1967
Risankizumab has been approved for the treatment of moderate-to-severe plaque psoriasis; however, real-life data are limited. Our objectives were to evaluate effectiveness and safety risankizumab its impact on quality life patients with psoriasis in a real-world setting. We retrospectively analyzed 154 from 18 centers Czech Republic who had undergone biologic therapy psoriasis. Baseline characteristics included comorbidities, demographics, previous therapies, Dermatology Life Quality Index...
Real-world data on the use of interleukin-17 (IL-17) inhibitors for treatment psoriasis are limited.To evaluate and compare efficacy, safety, drug survival IL-17 inhibitors.This retrospective study analyzed BIOREP registry patients treated with at least one inhibitor (secukinumab, ixekizumab, brodalumab).In total, 949 were included. The improvement in PASI score was significant all drugs, proportion achieving 75, 90, 100 after both 3 24 months therapy highest brodalumab, followed by...
Dupilumab has been approved to treat moderate-to-severe atopic dermatitis; however, the data in a real-world setting are still limited.To analyze effectiveness and safety of dupilumab.This was real-life Czech multicenter retrospective study from patients treated with dupilumab for severe AD.A total 360 were included. At 16 weeks, 66.6, 34.1, 5.5% achieved EASI75/90 EASI100, respectively. Improvement continued time, proportion EASI100 increased 89.5, 55.6, 12.9% after one year treatment...
Real-world data on the long-term use of guselkumab for treatment psoriasis are still limited. We aimed to evaluate efficacy, safety, and drug survival in a real-world setting. This is retrospective study analyzing Czech Republic registry (BIOREP) patients treated with guselkumab. In total, 333 were included. Improvement Psoriasis Area Severity Index (PASI) score was significant. Mean PASI decreased from 16 at baseline 0.7, 0.9, 0.8 after 12, 24, 36 months, respectively. Absolute scores ≤ 3 1...
The aim of this observational, multicenter study was to assess the real-world use brodalumab for treatment moderate-to-severe plaque psoriasis in patients Czech Republic, using data from BIOREP registry.
An 8-year-old boy with general pustular psoriasis (GPP) and iatrogenic secondary Cushing syndrome was treated successfully etanercept after he had failed on acitretin, methotrexate, methylprednisolone therapy. GPP is a severe very rare variant of in children often accompanied by life-threatening complications. Retinoids, cyclosporine, or dapsone used small number case series reports were effective. Etanercept recombinant human tumor necrosis factor-alpha (TNF-alpha) receptor protein fused Fc...
The basic principle of the management lymphedema is so called complex decongestive physical therapy. This therapy divided into two phases: (i) edema reduction phase--an initial intensive treatment phase aiming for limb volume reduction; and (ii) maintenance phase--following long-term to sustain a manageable volume. first consists number therapeutic approaches which are: manual lymph drainage, pneumatic pump low-stretch bandaging, exercises, skin care. Long-term self-lymph or compressive...
Abstract Background BIOREP is a Czech registry of psoriatic patients on biological treatment in clinical setting. We describe the characteristics with psoriasis at time enrollment and present comparisons published data from other national registries. Methods analyzed cohort treated biologics between May 2005 2015. Demographic data, previous therapies, comorbidities, severity were compared registries – DERMBIO , BIOBADADERM BADBIR PSOBEST . Results A total 1412 initiating included...
BIOREP is a Czech registry of patients with psoriasis undergoing biological treatment. The objective the study was to compare differences in demographic data, previous therapy, comorbidities, severity psoriasis, quality life, drug survival rates, and reasons for discontinuation between men women. We analyzed cohort from treated May 2005 January 2020. total population 2472 (4051 treatment series) included 913 females 1559 males. Women were significantly older than at onset (47.8 vs 45.4...
Background: Affective dysregulation and impaired cognitive control are implicated in the pathology of functional neurological disorders (FNDs). However, voluntary regulation emotions has seldom been researched this group patients. We hypothesized that patients with FNDs use inefficient emotion strategies regulate emotional reactions via increased motor activation. Methods: Fifteen movement disorder (FMD) fifteen healthy subjects matched by age, sex, education underwent an task fMRI. For...
The study describes the case of a patient with clinical and histopathological diagnosis pemphigus vulgaris accompanied by severe side-effects combined immunosuppressive therapy, who achieved remission disease adalimumab. Pemphigus is chronic blistering skin mucous membranes. Before corticosteroids were introduced, mortality was high. Corticosteroids are currently used as first-line therapy. To reduce dose corticosteroids, therapeutic combinations corticosteroid-sparing agents used. therapy...
The study aimed to evaluate the real-world effectiveness of adalimumab as well investigate persistence treatment and identify factors, which may affect it. More than 1150 patients (4363.1 patient-years) with psoriasis who had been treated since start BIOREP registry in Czech Republic were included this analysis. Treatment was defined improvement Psoriasis Area Severity Index (PASI). analysis performed during years 2005 2018. Patients on on-label dose. After 12 96 months therapy, 84% 88% a...
We report a case of Alternaria alternata cutaneous and pulmonary infection in 62-year-old man after heart transplantation treated by azole antifungals. spp. belong to group opportunistic dematiaceous fungi with worldwide distribution. The form the human is very rare occurs predominantly among immunosuppressed patients. Therefore, diagnosis often delayed or not reached at all. Appropriate treatment standardized remains matter discussion. According current studies, best results are obtained...
Leishmaniasis is an infectious disease caused by parasitic flagellates of the genus Leishmania. The authors present a case 44-year-old man with Crohn's treated successfully infliximab. This report shows rare visceral leishmaniasis cutaneous symptoms in immunocompromised patient. Skin manifestations may occur before or after infection and they are often diverse.
Psoriasis is now known to be associated with multiple other diseases/comorbidities - including the metabolic syndrome, atherosclerosis and gastrointestinal diseases which are all significantly higher in psoriasis patients. Research results however highly variable conclusions ambiguous. As no similar study has been performed date Czech psoriatic patients, this aimed at identifying risk factors early stages of selected patients.The was designed as a hospital-based case-control study. 131...
We present a case of 63-year old man with severe chronic plaque psoriasis and recent history lung cancer, wherein fever appeared suddenly after initiation treatment low dose acitretin. Tumor recurrence or infection was not found during extensive examinations, nevertheless the patient empirically treated broad-spectrum antibiotics without any effect on fever. Immediately discontinuation acitretin therapy, disappeared. The followed for next 2 years, this period similar problems did reappear,...
Adalimumab is the only approved biologic treatment for moderate‐to‐severe hidradenitis suppurativa, nonetheless, long‐term data from real‐life setting are still limited. The objective of this observational multicenter study was to evaluate effectiveness, safety, and drug survival adalimumab in patients with suppurativa included BIOREP registry. A total 299 who initiated therapy 2011 November 2021 were included. Dermatology‐Life‐Quality‐Index (DLQI), pain scale, number abscesses, inflammatory...
The aim of the study was to assess effectiveness and safety dupilumab therapy in patients with moderate-to-severe atopic dermatitis (AD) a real-life Czech bicentric cohort.We retrospectively analysed 50 AD treated two centres Republic. Baseline characteristics, Eczema Area Severity Index (EASI) score Dermatology Life Quality (DLQI) were collected at baseline each 3 following months. proportion achieving EASI50, EASI75, EASI90 EASI100 analysed. Levels immunoglobulin E (IgE) before after 6 12...
Psoriáza je chronické zánětlivé imunitně zprostředkované systémové onemocnění.Volba vhodného léčebného postupu závisí na mnoha faktorech.V posledních letech zaznamenala celková léčba psoriázy významný pokrok.K optimalizaci a individualizaci léčby byly sestaveny doporučené léčebné postupy
Abstract Study question Do ART clinics’ websites provide sufficient information for potential egg donors regarding all aspects related to donation? Summary answer There is an imbalance of provided online by clinics. The benefits exceed the side effects and risks associated with donation. What known already high demand in Czech Republic due extreme interest international couples procedures, e.g. because affordability treatment, lack a waiting list or extended age limit recipients up 49 years....