A5011078276- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Fungal Infections and Studies
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders
- Gut microbiota and health
- Reproductive tract infections research
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Autoimmune and Inflammatory Disorders Research
- Nonmelanoma Skin Cancer Studies
- Inflammatory Bowel Disease
- Childhood Cancer Survivors' Quality of Life
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Complementary and Alternative Medicine Studies
- Syphilis Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Gastrointestinal disorders and treatments
- Urinary and Genital Oncology Studies
- Drug-Induced Adverse Reactions
- Cervical Cancer and HPV Research
- Adolescent Sexual and Reproductive Health
- Diagnosis and treatment of tuberculosis
- Research on Leishmaniasis Studies
Charles University
2013-2019
Fakultní nemocnice Bulovka
2013-2019
Akershus University Hospital
2016
State Research Center for Dermatovenereology and Cosmetology
2013
Psoriasis is a chronic inflammatory skin disease in which Th17 cells play crucial role. Since indigenous gut microbiota influences the development and reactivity of immune cells, we analyzed link among microbiota, T formation psoriatic lesions imiquimod-induced murine model psoriasis. To explore role induced inflammation germ-free (GF), broad-spectrum antibiotic (ATB)-treated or conventional (CV) BALB/c C57BL/6 mice. We found that both mice reared GF conditions for several generations CV...
Psoriasis is a chronic inflammatory skin disease, whose pathogenesis involves dysregulated interplay among immune cells, keratinocytes and environmental triggers, including microbiota. Bacterial fungal dysbiosis has been recently associated with several immune-mediated diseases psoriasis. In this comprehensive study, we investigated how different sampling sites methods reflect the uncovered microbiota composition. After establishing most suitable approach, further examined correlations...
Psoriatic patients have altered microbiota, both in the intestine and on skin. It is not clear, however, whether this a cause or consequence of disease. In study, using an experimental mouse model psoriasis induced by imiquimod (IMQ), we show that oral treatment with broad spectrum antibiotics (MIX) metronidazole (MET) alone mitigates severity skin inflammation through downregulation Th17 immune response conventional mice. Since some antibiotics, including MET, can influence system...
The aim of the study was to determine prevalence Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis.In any stage syphilis swabs were performed from urethra, rectum, pharynx cervix according gender type sexual intercourse. From these smears standard validated nucleic acid amplification tests (NAATs) for infections done.From 548 (488 men, 60 women) screened co-infection detected in 15.9% cases. majority (86.2%) asymptomatic. overall...
We report a case of Alternaria alternata cutaneous and pulmonary infection in 62-year-old man after heart transplantation treated by azole antifungals. spp. belong to group opportunistic dematiaceous fungi with worldwide distribution. The form the human is very rare occurs predominantly among immunosuppressed patients. Therefore, diagnosis often delayed or not reached at all. Appropriate treatment standardized remains matter discussion. According current studies, best results are obtained...
Leishmaniasis is an infectious disease caused by parasitic flagellates of the genus Leishmania. The authors present a case 44-year-old man with Crohn's treated successfully infliximab. This report shows rare visceral leishmaniasis cutaneous symptoms in immunocompromised patient. Skin manifestations may occur before or after infection and they are often diverse.
To determine the incidence of malignancies in renal transplant recipients (RTRs) and to analyze association between risk skin cancer immunosuppressive regiments used posttransplant period.A cohort study was performed on 797 RTRs. Standardized morbidity ratio (SMR) calculated for most common types developed period different therapy cohort.192 cases were diagnosed 86 RTRs (10.8%). Nonmelanoma (NMSC) frequent type (SMR = 6.42, p 0.000), followed by 5.9, malignant melanoma 2.59, 0.080), prostate...
Treatment of anogenital warts was successful in an 11-year-old child with sinecatechins ointment 10%. After application for 10 weeks, the completely disappeared, without recurrence during a 12-week follow-up. well tolerated, notable side effects. Sinecatechins appear to be reasonable treatment children who have difficulty tolerating painful destructive therapy.
The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect early stages autoimmune diseases, such as Crohn's disease, ulcerative colitis coeliac disease in patients with psoriasis.This a hospital-based case-control study. Patients chronic plaque psoriasis were included cases. control group consisted other skin diseases who complied same selection criteria Two controls selected per one case. We analysed following antibodies (ASCA, AEP, p-ANCA,...
Since the notification of first case lymphogranuloma venereum (LGV) in Czech Republic 2010, numbers LGV cases have steadily increased country. In 2015, 40 were diagnosed, bringing total for 2010-2015, to 88 cases. The profile most affected group, HIV-positive men who sex with a previous sexually transmitted infection, matches that those described outbreaks western Europe.
Psoriasis is now known to be associated with multiple other diseases/comorbidities - including the metabolic syndrome, atherosclerosis and gastrointestinal diseases which are all significantly higher in psoriasis patients. Research results however highly variable conclusions ambiguous. As no similar study has been performed date Czech psoriatic patients, this aimed at identifying risk factors early stages of selected patients.The was designed as a hospital-based case-control study. 131...
The DCEUS in group 1 showed a slight decrease of PE and an increase RT, contrast 2, RT.In endoscopy, 4/7 patients had improvement endoscopic Mayo sub-scores (group 3), but none them reached complete remission.Further, 2/7 stable scores, patient deterioration macroscopic inflammation 4).In both groups, visible change was found terms parameters (Δ PE) fitting the findings endoscopy sub-score) (PE correlation rs = 0.698; significance p 0.088).Conclusions: Colour Doppler could become viable ways...
The DCEUS in group 1 showed a slight decrease of PE and an increase RT, contrast 2, RT.In endoscopy, 4/7 patients had improvement endoscopic Mayo sub-scores (group 3), but none them reached complete remission.Further, 2/7 stable scores, patient deterioration macroscopic inflammation 4).In both groups, visible change was found terms parameters (Δ PE) fitting the findings endoscopy sub-score) (PE correlation rs = 0.698; significance p 0.088).Conclusions: Colour Doppler could become viable ways...
Psoriáza je v současné době považována za systémovou nemoc, která se projevuje nejen na kůži a kloubech, ale také asociována s kardiovaskulárními, gastrointestinálními nemocemi psychiatrickými obtížemi.O komorbiditách psoriázy hovoří většinou u dospělých pacientů.Tímto článkem bychom rádi přispěli k rozšíření povědomí o dětí mezi dermatology, pediatry, revmatology, gastroenterology, kardiology podpořili mezioborovou spolupráci, neboť včasnou diagnostikou těchto nemocí můžeme zabránit...